다이버의 일회성 저수온 노출이 혈중 FGF21, Irisin 및 T3에 미치는 영향
Effect of a bout of acute cold water immersion on circulating FGF21, Irisin and T3 hormones in SCUBA divers
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초록
갈색지방 또는 베이지지방은 비 떨림 열 생성 기전을 통해 효율적으로 열을 생성한다. 최근 FGF21, irisin과 T3는 갈색지방을 활성시키는 호르몬으로써 추위에 노출됐을 때나 운동 시 증가되는 것으로 보고되었다. 따라서 이 연구는 추위에 장기간 간헐적으로 노출이 된 다이버들을 대상으로 일회성 잠수 후 혈중 FGF21, irisin과 T3의 농도 변화를 구명하고자 수행되었다. 연구의 대상은 최소 5년 이상의 잠수경력과 연 50-100회 이상 규칙적인 잠수 활동을 하는 7명의 남성 스쿠버다이버로 선정하였다. 다이버들은 수온 13-14℃인 동해바다에서 30분간 일회 잠수 활동을 수행하였다. 잠수 전, 직후 그리고 회복기 1시간 시점에 채혈을 실시하였고 혈액변인은 혈청 FGF21, 혈장 irisin, 혈청 T3, TG 그리고 FFA의 농도를 분석하였다. 다이버들의 일회 잠수 활동 직후 혈청 FGF21의 농도는 잠수 전에 비해 유의하게 증가하였다(p=.023, 138%). 또한 일회 잠수 직후에 비해 회복기 1시간 후 다이빙 전 수준으로 유의하게 감소하였다(p=.011, 65%). 반면에 irisin, T3 , TG와 FFA 농도는 잠수 직후 및 회복기 1시간 후 잠수 전에 비해 유의한 차이가 없었다. 이러한 결과를 종합적으로 고려할 때, 장기간 간헐적으로 추위에 노출된 스쿠버 다이버의 일회성 추위 노출 시 떨림에 의한 열 생성보다 비 떨림 열 생성에 의한 갈색지방 활성에 더 크게 영향을 미칠 가능성을 시사한다.
Abstract
PURPOSE: It has been understood that brown fat or beige adipose tissues can facilitate heat production through non-shivering thermogenesis. FGF21, irisin, or T3 hormones are believed to enhance brown fat activation and increase in cold environment and exercise. The purpose of this study was to determine the changes of circulating FGF21, irisin, T3 hormone concentrations during the acute diving activity in divers who have been undergone long-term intermittent cold exposure. METHODS: Seven SCUBA divers who have been diving at least for 5 years with 50 to 100 diving records per year participated in this study. A bout of acute diving was performed in the east sea (13-14 ℃) for 30 min. Blood samples were obtained from arm vein at pre- and post-diving, and after an hour recovery. Serum FGF21, Plasma irisin and serum T3, TG and FFA were assayed. RESULTS: Serum FGF21 level was increased after 30 min of diving (p=.043, 138%) compared to pre-diving and after one hour of recovery to pre-diving level (p=.018, 65%). However, plasma irisin, T3 , FFA, TG levels were unchanged both after post-diving and one hour recovery (p>.05). CONCLUSIONS: It is concluded that heat generation through non-shivering thermogenesis may play a major role during the acute diving activity in divers who have been undergone long-term intermittent cold exposure
참고문헌 (23)
- Bianco AC, "The role of thyroid hormone and brown adipose tissue in energy homoeostasis", The Lancet Diabetes & Endocrinology, 1(3), pp.250~258 (2013)
- BostrBm P, "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis", Nature, 481(7382), pp.463~468 (2012)
- Cypess AM, "Identification and importance of brown adipose tissue in adult humans", The New England Journal of Medicine, 360(15), pp.1509~1517 (2009)
- Davis TR, "Chamber cold acclimatization in man", Journal of applied physiology, 16(6), pp.1011~1015 (1961)
- Hanssen MJ, "Serum FGF21 levels are associated with brown adipose tissue activity in humans", Scientific Reports, 18(5), pp.10275~ (2015)
- Harms M, "Brown and beige fat: development, function and therapeutic potential", Nature Medicine, 19(10), pp.1252~1263 (2013)
- Lee P, "Hot fat in a cool man: infrared thermography and brown adipose tissue", Diabetes, Obesity and Metabolism, 13(1), pp.92~93 (2011)
- Lee P, "Mild cold exposure modulates fibroblast growth factor 21 (FGF21)diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis", The Journal of Clinical Endocrinology & Metabolism, 98(1), pp.98~102 (2013)
- Lee P, "Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans", Cell Metabolism, 19(2), pp.302~309 (2014)
- Ouellet V, "Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans", The Journal of Clinical Investigation, 122(2), pp.545~552 (2012)
- Petrovic N, "Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes", The Journal of Biological Chemistry, 285(10), pp.7153~7164 (2010)
- Saito M, "High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity", Diabetes, 58(7), pp.1526~1531 (2009)
- Saito M, "Human brown adipose tissue: regulation and anti-obesity potential", Endocrine Journal, 61(5), pp.409~416 (2014)
- Shibashi J, "Beige can be slimming", Science, 328(5982), pp.1113~1114 (2010)
- Silva JE, "Physiological importance and control of non-shivering facultative thermogenesis", Frontiers in bioscience, 3, pp.352~371 (2011)
- van der Lans AA, "Cold acclimation recruits human brown fat and increases nonshivering thermogenesis", The Journal of Clinical Investigation, 123(8), pp.3395~3403 (2013)
- van Marken Lichtenbelt WD, "Cold-activated brown adipose tissue in healthy men", The New England Journal of Medicine, 360(15), pp.1500~1508 (2009)
- Vegiopoulos A, "Cyclo-oxygenase-2 controls energy homeostasis in mice by denovo recruitment of brown adipocytes", Science, 328(5982), pp.1158~1161 (2010)
- Virtanen KA, "Functional brown adipose tissue in healthy adults", The New England Journal of Medicine, 360(15), pp.1518~1525 (2009)
- Virtanen KA, "BAT thermogenesis: Linking shivering to exercise", Cell Metabolism, 19(3), pp.352~354 (2014)
- Walden TB, "Recruited vs. nonrecruitedmolecular signatures of brown, “brite,” and white adipose tissues", American journal of physiology Endocrinology and Metabolism, 302(1), pp.19~31 (2012)
- Yoneshiro T, "Brown adipose tissue, whole- body energy expenditure, and thermogenesis in healthy adult men", Obesity, 19(1), pp.13~16 (2011)
- Yoneshiro T, "Recruited brown adipose tissue as an antibesity agent in humans", The Journal of Clinical Investigation, 123(8), pp.3404~3408 (2013)