16주 복합운동 프로그램이 중년 당뇨 여성의 혈중 지질과 미토콘드리아 DNA 손상에 미치는 영향
The effect of 16 weeks combined exercise training on lipid metabolism and DNA damage in middle-aged diabetic women
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본 연구의 목적은 중년 여성의 당뇨군(n=25)과 일반군(n=31)에서 혈중 지질과 미토콘드리아DNA손상에 대해 알아보고, 16주 운동훈련이 당뇨군(n=8)과 일반군(n=10)의 혈중 지질과 미토콘드리아 DNA의 손상에 미치는영향을 알아보았다. 일반군(n=31)과 당뇨군(n=25)을 비교하면, 혈중지질 중 TG(p<.01), 글루코스 농도(p<.001) 및 HOMA-IR (p<.05)은 당뇨군이 일반군보다 높은 것으로 나타났다. 산화스트레스 효소인 MDA에서는 유의한 차이가 나타나지 않았지만,당뇨군의 8-OHdG는 일반군보다 유의하게 높게 나타났으며(p<.01), 항산화효소인 SOD와 mtDNA 양은 당뇨군이 일반군보다유의하게 낮은 것으로 나타났다(p<.05). 대상자 중 당뇨군(n=8)과 일반군(n=10)을 대상으로 16주 복합운동 프로그램을 실시한결과, 두 집단 모두 체중(p<.001), BMI(p<.01), 체지방률(p<.01), WHR(p<.001), 이완기 혈압(p<.05), 글루코스(p<.01)와 HOMA -IR(p<.05)은 유의하게 감소하였으며, HDL(p<.05), TG(p<.01)와 글루코스(p<.001)는 그룹간 유의한 차이가 나타났다. 당뇨군의16주 복합운동 프로그램 후 MDA에서는 유의한 차이가 나타나지 않았으나, SOD에서는 그룹간 유의한 차이가 나타났다(p<.01), 당뇨군의 8-OHdG는 16주 복합운동 프로그램 후 유의하게 감소하였으나(p<.05), mtDNA양에서는 유의한 차이가 나타나지 않았다. 본 연구에서는 당뇨군의 DNA손상이 일반군보다 더 크게 나타났지만, 16주 복합운동 프로그램 후 인슐린 저항성, 항산화효소인 SOD와 DNA 손상지표인 8-OHdG는 개선되는 효과가 나타났다. 그러나 mtDNA양의 변화는 나타났지만 유의한 차이는 나타나지 않아 추후 연구에서 운동강도와 운동시간에 관한 연구가 필요하다고 사료된다.
Abstract
The purpose of this study was to compare to the different between diabetic middle-age women(n=25) and age-matched healthy women(n=31) on body composition, lipid profiles, and DNA damage factors. The comparison of control and diabetic were no significantly difference of weight, BMI, %fat, WHR, BP and V̇O2max. The diabetic group was significantly higher in TG(p<.01), glucose(p<.001), HOMA-IR(p<.05), 8-OHdG(p<.01) than control group. HDL-C(p<.01),SOD(p<.05), mtDNA contents(p<.05) were significantly lower in diabetic group. We also studied about the middle-aged women with diabetes(n=8) and age-matched healthy controls(n=10) after 16 weeks combined exercise training. Weight(p<.001), BMI(p<.01),%fat(p<.01), WHR(p<.001), DBP(p<.05), glucose(p<.01) and HOMA-IR(p<.05) were significantly decreased after exercise training, and there was significantly different between groups in HDL(p<.05), TG(p<.01), glucose(p<.001), and SOD(p<.01). 8-OHdG was significantly decreased in diabetic group(p<.05), but mtDNA contents was increased but not significantly different. It was concluded that DNA damage was higher in diabetic group, however, after 16weeks combined exercise training, insulin resistance, 8-OHdG were decreased, and SOD was increased in diabetic group. In conclusion, the present study demonstrated
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