골격근의 혈류차단 후 재 관류 시 운동훈련의 형태가 골격근 재생 및 회복에 미치는 영향
The Effect of Two-Week Resistance and Endurance Training on Skeletal Muscle Repair and Regeneration after Ischemia-Reperfusion in Rat
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PURPOSE: The present study examined the effect of two-week resistance and endurance training on skeletal muscle repair and regeneration after ischemia-reperfusion (IR) injury in rat. METHODS: Ten week-old male Sprague-Dawley (SD) rats were divided into three groups (IR-CON, IR-RE, IR-EN). To evaluate different property of muscle types, soleus (SOL) and extensor digitorum longus (EDL) muscle were dissected. We conducted confocal microscope experiment and western blot for evaluating cell cycle of skeletal muscle repair and regeneration. RESULTS: Satellite cells (SC) of SOL and EDL muscle were markedly increased after both exercise training. However myonuclear was only increased on SOL muscle. MyoD protein expression in SOL and EDL was increased after endurance exercise training. CONCLUSIONS: It is consider that exercise training after IR injury may affect to repair and regeneration of damaged skeletal muscle positively by increasing SC and myonuclear in all exercise training, despite a little different response follow muscle types.
Abstract
PURPOSE: The present study examined the effect of two-week resistance and endurance training on skeletal muscle repair and regeneration after ischemia-reperfusion (IR) injury in rat. METHODS: Ten week-old male Sprague-Dawley (SD) rats were divided into three groups (IR-CON, IR-RE, IR-EN). To evaluate different property of muscle types, soleus (SOL) and extensor digitorum longus (EDL) muscle were dissected. We conducted confocal microscope experiment and western blot for evaluating cell cycle of skeletal muscle repair and regeneration. RESULTS: Satellite cells (SC) of SOL and EDL muscle were markedly increased after both exercise training. However myonuclear was only increased on SOL muscle. MyoD protein expression in SOL and EDL was increased after endurance exercise training. CONCLUSIONS: It is consider that exercise training after IR injury may affect to repair and regeneration of damaged skeletal muscle positively by increasing SC and myonuclear in all exercise training, despite a little different response follow muscle types.
참고문헌 (45)
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