Association of VEGF protein expression according to muscle fiber types with diet and exercise intervention in diet-induced obese rats
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This study measured vascular endothelial growth factor (VEGF) protein expression of different skeletal muscle fiber types after a 6-week intervention of energy restriction and exercise in diet-induced obese rats. The changes in protein expression were analyzed across the different 6-weeks intervention programs of diet, exercise, and diet plus exercise. After intake of high fat diet for 6-weeks, obesity-induced groups showed a significantly higher body weight as compared to control group. The diet plus exercise (B) group showed a significantly lower visceral fat volume after 6-weeks, and obese group showed a higher visceral fat volume than the other groups. Diet alone group, and diet plus exercise (B) group showed a significantly higher VEGF protein expression in red gastrocnemius muscle after 6-weeks of treatment as compared to the pre-level of control group. The diet alone group, exercise group, and diet plus exercise (B) groups showed a significantly higher VEGF protein expression in white gastrocnemius muscle after 6-weeks of treatment as compared to the pre-level of obese group, but these groups showed no significant differences as compared to the pre-level of control group. The exercise group showed a significantly higher VEGF protein expression in soleus muscle after 6-weeks of treatment as compared to the pre-level of the control group, and the exercise group and diet group showed a significantly higher VEGF protein expression in soleus muscle after 6-weeks of treatment as compared to the post-level of the control group. In conclusion, VEGF protein expression of type IIb fibers in gastrocnemius white muscle showed a significant activation after exercise.
Abstract
This study measured vascular endothelial growth factor (VEGF) protein expression of different skeletal muscle fiber types after a 6-week intervention of energy restriction and exercise in diet-induced obese rats. The changes in protein expression were analyzed across the different 6-weeks intervention programs of diet, exercise, and diet plus exercise. After intake of high fat diet for 6-weeks, obesity-induced groups showed a significantly higher body weight as compared to control group. The diet plus exercise (B) group showed a significantly lower visceral fat volume after 6-weeks, and obese group showed a higher visceral fat volume than the other groups. Diet alone group, and diet plus exercise (B) group showed a significantly higher VEGF protein expression in red gastrocnemius muscle after 6-weeks of treatment as compared to the pre-level of control group. The diet alone group, exercise group, and diet plus exercise (B) groups showed a significantly higher VEGF protein expression in white gastrocnemius muscle after 6-weeks of treatment as compared to the pre-level of obese group, but these groups showed no significant differences as compared to the pre-level of control group. The exercise group showed a significantly higher VEGF protein expression in soleus muscle after 6-weeks of treatment as compared to the pre-level of the control group, and the exercise group and diet group showed a significantly higher VEGF protein expression in soleus muscle after 6-weeks of treatment as compared to the post-level of the control group. In conclusion, VEGF protein expression of type IIb fibers in gastrocnemius white muscle showed a significant activation after exercise.
참고문헌 (22)
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