운동에 의한 장내미생물과 유래 대사산물의 변화가 뇌혈관 건강 및 알츠하이머 질환에 미치는 잠재적 영향

키워드

참고문헌 (106)

1. Xu H, "The role of the gut microbiome and its metabolites in cerebrovascular diseases", Front Microbiol, 14, pp.1097148~ (2023)
2. Chen ML, "Trimethylamine-Noxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway", J Am Heart Assoc, 6(9) (2017)
3. Huang Q, "Alterations in the gut microbiome with hemorrhagic transformation in experimental stroke", CNS Neurosci Ther, 28(1), pp.77~91 (2022)
4. Corriveau RA, "Alzheimer’s disease-related dementias summit 2016 : national research priorities", Neurology, 89(23), pp.2381~2391 (2017)
5. Austin BP, "Effects of hypoperfusion in Alzheimer's disease", J Alzheimers Dis, 26, pp.123~133 (2011)
6. Binnewijzend MA, "Cerebral blood flow measured with 3D pseudocontinuous arterial spin-labeling MR imaging in Alzheimer disease and mild cognitive impairment : a marker for disease severity", Radiology, 267(1), pp.221~230 (2013)
7. Toth P, "Functional vascular contributions to cognitive impairment and dementia : mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging", Am J Physiol Heart Circ Physiol, 312(1), pp.1~20 (2017)
8. Yan S, "Protective effects of butyrate on cerebral ischaemic injury in animal models : a systematic review and meta-analysis", Front Neurosci, 18, pp.1304906~ (2024)
9. De Silva TM, "Microvascular dysfunction and cognitive impairment", Cell Mol Neurobiol, 36(2), pp.241~258 (2016)
10. Bohlen HG, "Evidence of myogenic vascular control in the rat cerebral cortex", Circ Res, 55(4), pp.554~559 (1984)
11. Brayden JE, "Transient receptor potential(TRP)channels, vascular tone and autoregulation of cerebral blood flow", Clin Exp Pharmacol Physiol, 35(9), pp.1116~1120 (2008)
12. Fan F, "Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat", Am J Physiol Regul Integr Comp Physiol, 308(5), pp.379~390 (2015)
13. Ge Y, "Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats", Am J Physiol Renal Physiol, 307(5), pp.F509~15 (2014)
14. Harder DR, "Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow", Am J Physiol Heart Circ Physiol, 300(5), pp.H1557~65 (2011)
15. Cipolla MJ, "Pressure-induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behavior", FASEB J, 16(1), pp.72~76 (2002)
16. Reading SA, "Central role of TRPM4 channels in cerebral blood flow regulation", Stroke, 38(8), pp.2322~2328 (2007)
17. Schubert R, "The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction", Cardiovasc Res, 77(1), pp.8~18 (2008)
18. Hortobagyi L, "Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids", Brain Res, 1131(1), pp.129~137 (2007)
19. Furchgott RF, "Endothelium-derived relaxing and contracting factors", FASEB J, 3(9), pp.2007~2018 (1989)
20. Attwell D, "Glial and neuronal control of brain blood flow", Nature, 468(7321), pp.232~243 (2010)
21. Porter JT, "Hippocampal astrocytes in situ respond to glutamate released from synaptic terminals", J Neurosci, 16(16), pp.5073~5081 (1996)
22. Strandgaard S. Autoregulation of cerebral blood flow in hypertensive patients, "Autoregulation of cerebral blood flow in hypertensive patients. The modifying influence of prolonged antihypertensive treatment on the tolerance to acute, drug-induced hypotension", Circulation, 53(4), pp.720~727 (1976)
23. Rand AA, "Epoxyeicosatrienoic acid(EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids(EHETs)formed from COX-2", J Lipid Res, 60(12), pp.1996~2005 (2019)
24. Davis CM, "Cytochrome P450 eicosanoids in cerebrovascular function and disease", Pharmacol Ther, 179, pp.31~46 (2017)
25. Fleming I, "The pharmacology of the cytochrome P450 epoxygenase", soluble epoxide hydrolase axis in the vasculature and cardiovascular disease, 2014, pp.66(4), 1106~1140
26. Fernandes J, "IP3 sensitizes TRPV4 channel to the mechano-and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid", J Cell Biol, 181(1), pp.143~155 (2008)
27. Nilius B, "The TRPV4 channel : structure-function relationship and promiscuous gating behaviour", Pflugers Arch, 446(3), pp.298~303 (2003)
28. Cheng J, "20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling", J Pharmacol Exp Ther, 332(1), pp.57~65 (2010)
29. Liu X, "Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex", Am J Physiol Heart Circ Physiol, 295(2), pp.H619~31 (2008)
30. Eggermont L, "Exercise, cognition and Alzheimer's disease : more is not necessarily better", Neurosci Biobehav Rev, 30(4), pp.562~575 (2006)
31. Tosun D, "Discriminative power of arterial spin labeling magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography changes for amyloid-beta-positive subjects in the Alzheimer’s disease continuum", Neurodegener Dis, 16(1), pp.87~94 (2016)
32. Benedictus MR, "Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease", Eur Radiol, 27(3), pp.1169~1175 (2017)
33. Chao LL, "ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia", Alzheimer Dis Assoc Disord, 24(1), pp.19~27 (2010)
34. Wolters FJ, "Cerebral perfusion and the risk of dementia : a population-based study", Circulation, 136(8), pp.719~728 (2017)
35. Xekardaki A, "Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals", Radiology, 274(2), pp.490~499 (2015)
36. Park L, "Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain", J Cereb Blood Flow Metab, 27(12), pp.1908~1918 (2007)
37. Toth P, "Resveratrol treatment rescues neurovascular coupling in aged mice : role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase", Am J Physiol Heart Circ Physiol, 306(3), pp.H299~308 (2014)
38. Deer RR, "Effects of estrogen on cerebrovascular function : age-dependent shifts from beneficial to detrimental in small cerebral arteries of the rat", Am J Physiol Heart Circ Physiol, 310(10), pp.H1285~94 (2016)
39. de Cavanagh EM, "Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition", Am J Physiol Heart Circ Physiol, 309(1), pp.15~44 (2015)
40. Flavahan S, "Local renin-angiotensin system mediates endothelial dilator dysfunction in aging arteries", Am J Physiol Heart Circ Physiol, 311(3), pp.H849~854 (2016)
41. Park SY, "Impact of age on the vasodilatory function of human skeletal muscle feed arteries", Am J Physiol Heart Circ Physiol, 310(2), pp.217~225 (2016)
42. Sabayan B, "Markers of endothelial dysfunction and cerebral blood flow in older adults", Neurobiol Aging, 35(2), pp.373~377 (2014)
43. Wang N, "Cerebral small vessel disease and motoric cognitive risk syndrome : results from the kerala-einstein study", J Alzheimers Dis, 50(3), pp.699~707 (2016)
44. Austin SA, "Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology", J Neurochem, 127(5), pp.691~700 (2013)
45. Hansen DV, "Microglia in Alzheimer's disease", J Cell Biol, 217(2), pp.459~472 (2018)
46. Diaz-Otero JM, "Transient receptor potential vanilloid 4 channels are important regulators of parenchymal arteriole dilation and cognitive function", Microcirculation, 26(6), pp.e12535~ (2019)
47. Kaur D, "Activation of microglia and astrocytes : a roadway to neuroinflammation and Alzheimer's disease", Inflammopharmacology, 27(4), pp.663~677 (2019)
48. Toth L, "Agerelated decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults", Geroscience, 44(6), pp.2771~2783 (2022)
49. Tarantini S, "Impaired neurovascular coupling in aging and Alzheimer's disease : Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline", Exp Gerontol, 94, pp.52~58 (2017)
50. Toth P, "Purinergic glio-endothelial coupling during neuronal activity : role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex", Am J Physiol Heart Circ Physiol, 309(11), pp.1837~1845 (2015)
51. Toth P, "IGF-1deficiency impairs neurovascular coupling in mice : implications for cerebromicrovascular aging", Aging Cell, 14(6), pp.1034~1044 (2015)
52. Toth P, "Aging exacerbates hypertension-induced cerebral microhemorrhages in mice : role of resveratrol treatment in vasoprotection", Aging Cell, 14(3), pp.400~408 (2015)
53. Hock C, "Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy(NIRS)--correlation with simultaneous rCBF-PET measurements", Brain Res, 755(2), pp.293~303 (1997)
54. Janik R, "Attenuation of functional hyperemia to visual stimulation in mild Alzheimer's disease and its sensitivity to cholinesterase inhibition", Biochim Biophys Acta, 1862(5), pp.957~965 (2016)
55. Rombouts SA, "Functional MR imaging in Alzheimer’s disease during memory encoding", AJNR Am J Neuroradiol, 21(10), pp.1869~1875 (2000)
56. Zhu W, "Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk", Cell, 165(1), pp.111~124 (2016)
57. Sun S, "Gut microbiota composition and blood pressure", Hypertension, 73(5), pp.998~1006 (2019)
58. Yang T, "Gut dysbiosis is linked to hypertension", Hypertension, 65(6), pp.1331~1340 (2015)
59. Adnan S, "Alterations in the gut microbiota can elicit hypertension in rats", Physiol Genomics, 49(2), pp.96~104 (2017)
60. de la Cuesta-Zuluaga J, "Higher fecal short-chain fatty acid levels are associated with gut microbiome dysbiosis, obesity, hypertension and cardiometabolic disease risk factors", Nutrients, 11(1) (2018)
61. Marques FZ, "High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice", Circulation, 135(10), pp.964~977 (2017)
62. Waghulde H, "Attenuation of microbiotal dysbiosis and hypertension in a CRISPR", Cas9 gene ablation rat model of GPER1, 2018, pp.72(5), 1125~1132
63. Rustia AJ, "Microbial disruption in the gut promotes cerebral endothelial dysfunction", Physiol Rep, 9(21), pp.e15100~ (2021)
64. Cryan JF, "The Microbiota-gut-brain axis", Physiol Rev, 99(4), pp.1877~2013 (2019)
65. Brunt VE, "Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans", Hypertension, 76(1), pp.101~112 (2020)
66. Sun X, "Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome", Biochem Biophys Res Commun, 481, pp.63~70 (2016)
67. Seldin MM, "Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-kappaB", J Am Heart Assoc, 5(2) (2016)
68. Zhang X, "Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3(Nucleotide-binding domain, leucine-rich-containing family, pyrin domaincontaining-3)Inflammasome and NF-kappaB(Nuclear Factor kappaB)signals", Arterioscler Thromb Vasc Biol, 40(3), pp.751~765 (2020)
69. Ma G, "Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion", Biosci Rep, 37(2) (2017)
70. Vogt NM, "The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease", Alzheimers Res Ther, 10(1), pp.124~ (2018)
71. Luo YX, "Gut microbiota-host lipid crosstalk in Alzheimer's disease : implications for disease progression and therapeutics", Mol Neurodegener, 19(1), pp.35~ (2024)
72. Zhou S, "Dietary choline metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity declining through the mTOR", P70S6K, Food Funct, pp.2023, 14(6)[DOI]
73. Gao Q, "Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice : a potential therapeutic approach for Alzheimer's disease", Aging(Albany NY), 11(19), pp.8642~8663 (2019)
74. Mirzaei R, "Role of microbiota-derived short-chain fatty acids in nervous system disorders", Biomed Pharmacother, 139, pp.111661~ (2021)
75. Verhaar BJH, "Gut Microbiota in Hypertension and Atherosclerosis: A Review", Nutrients, 12(10) (2020)
76. Ling Y, "Gut microbiome signatures are biomarkers for cognitive impairment in patients with ischemic stroke", Front Aging Neurosci, 12, pp.511562~ (2020)
77. Wu L, "Altered gut microbial metabolites in amnestic mild cognitive impairment and Alzheimer’s disease: signals in host-microbe interplay", Nutrients, 13(1) (2021)
78. Qian XH, "Mechanisms of shortchain fatty acids derived from gut microbiota in Alzheimer’s disease", Aging Dis, 13(4), pp.1252~1266 (2022)
79. Liu J, "Anti-neuroinflammatory effect of short-chain fatty acid acetate against Alzheimer’s disease via Upregulating GPR41 and Inhibiting ERK", JNK, J Agric Food Chem, pp.2020, 68(27)[DOI]
80. Hoyles L, "Microbiome-host systems interactions : protective effects of propionate upon the blood-brain barrier", Microbiome, 6(1), pp.55~ (2018)
81. Govindarajan N, "Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression", J Alzheimers Dis, 26(1), pp.187~197 (2011)
82. Ge X, "Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models", J Clin Invest, 133(4) (2023)
83. Zhan X, "Gram-negative bacterial molecules associate with Alzheimer disease pathology", Neurology, 87(22), pp.2324~2332 (2016)
84. Zhao Y, "Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer's Disease Brain", Front Immunol, 8, pp.1064~ (2017)
85. Kim HS, "Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease : pathologic roles and therapeutic implications", Transl Neurodegener, 10(1), pp.49~ (2021)
86. Brown GC, "The endotoxin hypothesis of neurodegeneration", J Neuroinflammation, 16(1), pp.180~ (2019)
87. Wu Z, "Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice", Brain Behav Immun, 65, pp.350~361 (2017)
88. Yao C, "Lipopolysaccharide induces inflammatory microglial activation through CD147-mediated matrix metalloproteinase expression", Environ Sci Pollut Res Int, 30(12), pp.35352~35365 (2023)
89. Barton W, "The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level", Gut, 67(4), pp.625~633 (2018)
90. Cook MD, "Forced treadmill exercise training exacerbates inflammation and causes mortality while voluntary wheel training is protective in a mouse model of colitis", Brain Behav Immun, 33, pp.46~56 (2013)
91. Zhao X, "Response of gut microbiota to metabolite changes induced by endurance exercise", Front Microbiol, 9, pp.765~ (2018)
92. Karl JP, "Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress", Am J Physiol Gastrointest Liver Physiol, 312(6), pp.559~571 (2017)
93. Keohane DM, "Four men in a boat : ultra-endurance exercise alters the gut microbiome", J Sci Med Sport, 22(9), pp.1059~1064 (2019)
94. Clauss M, "Interplay between exercise and gut microbiome in the context of human health and performance", Front Nutr, 8, pp.637010~ (2021)
95. Estaki M, "Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions", Microbiome, 4(1), pp.42~ (2016)
96. Durk RP, "Gut microbiota composition is related to cardiorespiratory fitness in healthy young adults", Int J Sport Nutr Exerc Metab, 29(3), pp.249~253 (2019)
97. Morita E, "Aerobic exercise training with brisk walking increases intestinal bacteroides in healthy elderly women", Nutrients, 11(4) (2019)
98. Allen JM, "Exercise alters gut microbiota composition and function in lean and obese humans", Med Sci Sports Exerc, 50(4), pp.747~757 (2018)
99. Munukka E, "Sixweek endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women", Front Microbiol, 9, pp.2323~ (2018)
100. Motiani KK, "Exercise training modulates gut microbiota profile and improves endotoxemia", Med Sci Sports Exerc, 52(1), pp.94~104 (2020)
101. Petersen LM, "Community characteristics of the gut microbiomes of competitive cyclists", Microbiome, 5(1), pp.98~ (2017)
102. Brandt N, "The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice", Physiol Rep, 6(20), pp.e13881~ (2018)
103. Denou E, "High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity", Am J Physiol Endocrinol Metab, 310(11), pp.982~993 (2016)
104. McCabe LR, "Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice", Bone, 118, pp.20~31 (2019)
105. Abraham D, "Exercise and probiotics attenuate the development of Alzheimer’s disease in transgenic mice : Role of microbiome", Exp Gerontol, 115, pp.122~131 (2019)
106. Dalton A, "Exercise influence on the microbiome-gut-brain axis", Gut Microbes, 10(5), pp.555~568 (2019)

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