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운동 및 프로바이오틱스 중재가 뇌혈관 기능 이상과 알츠하이머 질환 개선에 미치는 영향

Effects of Exercise and Probiotics Interventions on Cerebrovascular Dysfunction and Alzheimer's Disease

홍광석|이동현
학교체육연구소 (Physical Education Lab of Chung-Ang University)|2024.11|Asian Journal of Physical Education and Sport Science|제12권 제6호|pp. 161-179

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참고문헌

키워드

운동Exerciseprobiotics프로바이오틱스장내 미생물 유래 대사산물염증성 사이토카인퇴행성 뇌신경질환gut microbiome-derived metabolitesinflammatory cytokinesneurodegenerative disease
주제분류체육

초록

본 연구는 알츠하이머 질환의 병리적 진행에 있어 장내 미생물 특성과 뇌혈관 기능이 미치는 영향을 다각적으로 분석하고, 퇴행성 뇌신경질환 개선을 위한 비약물적 중재의 효과와 그 가능성을 정리하였다. 알츠하이머 질환은 뇌 조직 내 아밀로이드 베타 플라크 축적과 타우 단백질의 과인산화로 인한 신경 퇴행성 손상이 주요 원인으로 알려져 있으며, 이러한 병리적 변화는 심혈관 기능 손상과 장내 미생물의 불균형과 밀접한 연관이 있다. 특히 장내 미생물 유래 대사산물은 염증성 사이토카인의 발현조절을 통해 심혈관 보호 효과를 나타내며, 규칙적인 운동과 프로바이오틱스 섭취가 장내 미생물의 생태계에 유익한 변화를 일으켜 염증을 억제하고 혈관 기능을 향상시키므로 알츠하이머 질환의 예방 및 관리에 긍정적 영향을 미칠 수 있음을 시사한다. 이에 본 연구는 장내 미생물 조절과 뇌혈관 건강 개선이 알츠하이머 질환 예방 및 치료를 위한 새로운 비약물적 접근법으로유용하게 활용될 가능성을 제안하며 이를 입증하기 위한 추가 연구의 필요성을 강조하였다.

Abstract

This study explores the influence of gut microbiome and cerebrovascular function on the pathological progression of Alzheimer’s disease and summarizes the effectiveness and potential of non-pharmacological interventions to improve these factors. Alzheimer’s disease is known to be caused by neurodegenerative damage due to the accumulation of amyloid-beta plaques and the hyperphosphorylation of tau protein in the brain, changes closely linked to cardiovascular dysfunction and gut dysbiosis. In particular, metabolites derived from gut microbiota exhibit cardiovascular protective effects by modulating the expression of inflammatory cytokines. Regular exercise and probiotic dietary can positively alter the gut microbiome composition/diversity, reducing inflammation and improving vascular function, thereby potentially contributing to the prevention and treatment of Alzheimer’s disease. This study suggests that regulating the gut microbiome and enhancing cerebrovascular health may serve as promising non-pharmacological approaches for Alzheimer’s prevention and treatment, emphasizing the need for further research to demonstrate these strategies.

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