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RNA therapy

김영국
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2023.12|Experimental and Molecular Medicine|제55권 |pp. 1281-1282|DOI 10.1038/s12276-023-01051-8

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주제분류생화학

초록

RNA therapy is defined as the prevention or treatment of disease using RNA-based molecules. In a previous review, I categorized RNA therapy based on the chemistry of various RNA molecules into the categories of antisense RNA, small-interfering RNA (siRNA), RNA aptamers, and messenger RNA (mRNA)1. Each exerts its function by targeting different types of genetic material within cells.

Abstract

RNA therapy is defined as the prevention or treatment of disease using RNA-based molecules. In a previous review, I categorized RNA therapy based on the chemistry of various RNA molecules into the categories of antisense RNA, small-interfering RNA (siRNA), RNA aptamers, and messenger RNA (mRNA)1. Each exerts its function by targeting different types of genetic material within cells.

참고문헌 (15)

  1. Kim Young-Kook, "RNA therapy: rich history, various applications and unlimited future prospects", Experimental and Molecular Medicine, 54, pp.1~11 (2022), 생화학분자생물학회[DOI]
  2. Min, H. Y., "MicroRNA : trends in clinical trials of cancer diagnosis and therapy strategies", Exp. Mol. Med, 54, pp.1670~1694 (2022)
  3. Frankish, A., "Gencode 2021", Nucleic Acids Res, 49, pp.D916~D923 (2021)
  4. Bartel, D. P., "Metazoan MicroRNAs", Cell, 173, pp.20~51 (2018)
  5. Lu, J., "MicroRNA expression profiles classify human cancers", Nature, 435, pp.834~838 (2005)
  6. Rosenfeld, N., "MicroRNAs accurately identify cancer tissue origin", Nat. Biotechnol, 26, pp.462~469 (2008)
  7. Kim Taewan, "MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies", Experimental and Molecular Medicine, 55, pp.1314~1321 (2023), 생화학분자생물학회[DOI]
  8. Claycomb, J. M., "Ancient endo-siRNA pathways reveal new tricks", Curr. Biol, 24, pp.R703~R715 (2014)
  9. Setten, R. L, "The current state and future directions of RNAibased therapeutics", Nat. Rev. Drug Discov, 18, pp.421~446 (2019)
  10. Lorenzer, C., "Going beyond the liver : progress and challenges of targeted delivery of siRNA therapeutics", J. Control Release, 203, pp.1~15 (2015)
  11. Nair, J. K., "Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing", J. Am. Chem. Soc, 136, pp.16958~16961 (2014)
  12. Ahn Insook, "Where should siRNAs go: applicable organs for siRNA drugs", Experimental and Molecular Medicine, 55, pp.1283~1292 (2023), 생화학분자생물학회[DOI]
  13. Lee Saebyeol, "Emerging roles of tRNA-derived small RNAs in cancer biology", Experimental and Molecular Medicine, 55, pp.1293~1304 (2023), 생화학분자생물학회[DOI]
  14. Chaudhary, N., "mRNA vaccines for infectious diseases : principles, delivery and clinical translation", Nat. Rev. Drug Discov, 20, pp.817~838 (2021)
  15. Lee Jisun, "Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines", Experimental and Molecular Medicine, 55, pp.1305~1313 (2023), 생화학분자생물학회[DOI]

관련 논문AI추천

RNA therapy: rich history, various applications and unlimited future prospects김영국생화학분자생물학회 · Experimental and Molecular Medicine2022 · 제54권 New paradigms on siRNA local applicationHuiming He, Jinwen Ni, Meng Pan, Shan Gao, Xiaohong Duan생화학분자생물학회 · BMB Reports2015 · 제48권 제3호Regulatory RNA: from molecular insights to therapeutic frontiers김태경, Kim TaeSoo생화학분자생물학회 · Experimental and Molecular Medicine2024 · 제56권 Molecular insights into regulatory RNAs in the cellular machinery주재열, Kang Mingon, Kim Sung-Hyun, Yang Eunjeong, Yang Sumin생화학분자생물학회 · Experimental and Molecular Medicine2024 · 제56권 Therapeutic aptamers: developmental potential as anticancer drugs허균, 김현정, 이지원생화학분자생물학회 · BMB Reports2015 · 제48권 제4호Where should siRNAs go: applicable organs for siRNA drugsAhn Insook, Han Jinju, Kang Chanhee S.생화학분자생물학회 · Experimental and Molecular Medicine2023 · 제55권

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