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Therapeutic aptamers: developmental potential as anticancer drugs

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초록

Aptamers, composed of single-stranded DNA or RNA oligonucleotides that interact with target molecules through a specific three-dimensional structure, are selected from pools of combinatorial oligonucleotide libraries. With their high specificity and affinity for target proteins, ease of synthesis and modification, and low immunogenicity and toxicity, aptamers are considered to be attractive molecules for development as anticancer therapeutics. Two aptamers - one targeting nucleolin and a second targeting CXCL12 - are currently undergoing clinical trials for treating cancer patients, and many more are under study. In this mini-review, we present the current clinical status of aptamers and aptamer-based cancer therapeutics. We also discuss advantages, limitations, and prospects for aptamers as cancer therapeutics.

Abstract

Aptamers, composed of single-stranded DNA or RNA oligonucleotides that interact with target molecules through a specific three-dimensional structure, are selected from pools of combinatorial oligonucleotide libraries. With their high specificity and affinity for target proteins, ease of synthesis and modification, and low immunogenicity and toxicity, aptamers are considered to be attractive molecules for development as anticancer therapeutics. Two aptamers - one targeting nucleolin and a second targeting CXCL12 - are currently undergoing clinical trials for treating cancer patients, and many more are under study. In this mini-review, we present the current clinical status of aptamers and aptamer-based cancer therapeutics. We also discuss advantages, limitations, and prospects for aptamers as cancer therapeutics.

참고문헌 (45)

  1. Scott AM, "Antibody therapy of cancer", Nat Rev Cancer, 12, pp.278~287 (2012)
  2. Liu JKH, "The history of monoclonal antibody development-Progress, remaining challenges and future innovations", Ann Med Surg, 3, pp.113~116 (2014)
  3. Chames P, "Therapeutic antibodies: successes, limitations and hopes for the future", Br J Pharmacol, 157, pp.220~233 (2009)
  4. Tabrizi M, "Biodistribution mechanisms of therapeutic monoclonal antibodies in health and disease", AAPS J, 12, pp.33~43 (2010)
  5. Miller MJ, "Cancer immunotherapy:present status, future perspective, and a new paradigm of peptide immunotherapeutics", Discov Med, 15, pp.166~176 (2013)
  6. Jain RK, "Delivering nanomedicine to solid tumors", Nat Rev Clin Oncol, 7, pp.653~664 (2010)
  7. Beckman RA, "Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors", Cancer, 109, pp.170~179 (2007)
  8. Sung HJ, "Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8", Biomaterials, 35, pp.578~589 (2014)
  9. Kim YH, "An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells", Cancer Lett, 313, pp.76~83 (2011)
  10. Tuerk C, "Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase", Science, 249, pp.505~510 (1990)
  11. Keefe AD, "Aptamers as therapeutics", Nat Rev Drug Discov, 9, pp.537~550 (2010)
  12. 공훈영, "Nucleic Acid Aptamers: New Methods for Selection, Stabilization,and Application in Biomedical Science", Biomolecules & Therapeutics, 21(6), pp.423~434 (2013), 한국응용약물학회
  13. Sun H, "Oligonucleotide aptamers: new tools for targeted cancer therapy", Mol Ther Nucleic Acids, 3, pp.e182~ (2014)
  14. Dong Y, "Aptamer and its potential applications for food safety", Crit Rev Food Sci Nutr, 54, pp.1548~1561 (2014)
  15. Song KM, "Aptamers and Their Biological Applications", Sensors (Basel), 12, pp.612~631 (2012)
  16. Tan W, "Molecular aptamers for drug delivery", Trends Biotechnol, 29, pp.634~640 (2011)
  17. Pendergrast PS, "Nucleic acid aptamers for target validation and therapeutic applications", J Biomol Tech, 16, pp.224~234 (2005)
  18. Bates PJ, "Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer", Exp Mol Pathol, 86, pp.151~164
  19. Tajrishi MM, "Nucleolin : The most abundant multifunctional phosphoprotein of nucleolus", Commun Integr Biol, 4, pp.267~275 (2011)
  20. Zhu J, "Progress in aptamer-mediated drug delivery vehicles for cancer targeting and its implications in addressing chemotherapeutic challenges", Theranostics, 4, pp.931~944 (2014)
  21. Laber DA, "Update on the first phase I study of AGRO100 in advanced cancer", J Clin Oncol, 23, pp.3064~ (2005)
  22. Ni X, "Nucleic acid aptamers: clinical applications and promising new horizons", Curr Med Chem, 18, pp.4206~4214 (2011)
  23. Nagasawa T, "Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF", SDF-1, 1996, pp.382, 635~638
  24. Sun X, "CXCL12", CXCR4, Cancer Metastasis Rev, pp.2010, 29[DOI]
  25. Shum KT, "Nucleic Acid Aptamers as Potential Therapeutic and Diagnostic Agents for Lymphoma", J Cancer Ther, 4, pp.872~890 (2013)
  26. Hoellenriegel J, "The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization", Blood, 123, pp.1032~1039 (2014)
  27. Liu SC, "Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats", Neuro Oncol, 16, pp.21~28 (2014)
  28. Zhou J, "Cell-type-specific, Aptamerfunctionalized Agents for Targeted Disease Therapy", Mol Ther Nucleic Acids, 3, pp.e169~ (2014)
  29. Bruno JG, "A review of therapeutic aptamer conjugates with emphasis on new approaches", Pharmaceuticals (Basel), 6, pp.340~357 (2013)
  30. Farokhzad OC, "Nanoparticle-aptamer bioconjugates:a new approach for targeting prostate cancer cells", Cancer Res, 64, pp.7668~7672 (2004)
  31. Farokhzad OC, "Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo", Proc Natl Acad Sci U S A, 103, pp.6315~6320 (2006)
  32. Yu C, "Novel aptamer-nanoparticle bioconjugates enhances delivery of anticancer drug to MUC1-positive cancer cells in vitro", PLoS One, 6, pp.e24077~ (2011)
  33. McNamara JO, "Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras", Nat Biotechnol, 24, pp.1005~1015 (2006)
  34. Leal M, "Antibody-drug conjugates: an emerging modality for the treatment of cancer", Ann N Y Acad Sci, 1321, pp.41~54 (2014)
  35. Perez HL, "Antibody-drug conjugates: current status and future directions", Drug Discov Today, 19, pp.869~881 (2014)
  36. Shigdar S, "Aptamers as theranostic agents: modifications, serum stability and functionalisation", Sensors (Basel), 13, pp.13624~13637 (2013)
  37. Griffin LC, "In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits", Blood, 81, pp.3271~3276 (1993)
  38. Davydova AS, "Escort aptamers: new tools for the targeted delivery of therapeutics into cells", Acta Naturae, 3, pp.12~29 (2011)
  39. Ng EW, "Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease", Nat Rev Drug Discov, 5, pp.123~132 (2006)
  40. Lakhin AV, "Aptamers : problems, solutions and prospects", Acta Naturae, 5, pp.34~43 (2013)
  41. Healy JM, "Pharmacokinetics and biodistribution of novel aptamer compositions", Pharm Res, 21, pp.2234~2246 (2004)
  42. Ruggiero A, "Paradoxical glomerular filtration of carbon nanotubes", Proc Natl Acad Sci U S A, 107, pp.12369~12374 (2010)
  43. Burmeister PE, "Direct in vitro selection of a 2'-O-methyl aptamer to VEGF", Chem Biol, 12, pp.25~33 (2005)
  44. Shapiro A, "Anti-VEGF state of the union", Retina Today, pp.32~34 (2012)
  45. Kaiser PK, "Balancing risk in ophthalmic prescribing: assessing the safety of anti-VEGF therapies and the risks associated with unlicensed medicines", Graefes Arch Clin Exp Ophthalmol, 250, pp.1563~1571 (2012)

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