Regulatory RNA: from molecular insights to therapeutic frontiers
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Over the years, advancements in modern molecular biology have shed light on the complex roles of RNA molecules. It is now well established that RNAs serve as more than just passive messengers in genetic information flow; rather, they play critical roles in coordinating diverse cellular functions by fine-tuning gene regulation, especially in complex organisms where these processes are intricate1,2. Our understanding of gene regulation has undergone a profound transformation with the discovery and characterization of regulatory RNAs.
Abstract
Over the years, advancements in modern molecular biology have shed light on the complex roles of RNA molecules. It is now well established that RNAs serve as more than just passive messengers in genetic information flow; rather, they play critical roles in coordinating diverse cellular functions by fine-tuning gene regulation, especially in complex organisms where these processes are intricate1,2. Our understanding of gene regulation has undergone a profound transformation with the discovery and characterization of regulatory RNAs.
참고문헌 (14)
- Mercer, T. R., "Long non-coding RNAs : insights into functions", Nat. Rev. Genet, 10, pp.155~159 (2009)
- Morris, K. V., "The rise of regulatory RNA", Nat. Rev. Genet, 15, pp.423~437 (2014)
- Carninci, P., "The transcriptional landscape of the mammalian genome", Science, 309, pp.1559~1563 (2005)
- Hwang, H., "Determinants of functional MicroRNA targeting", Mol. Cells, 46, pp.21~32 (2023)
- Mattick, J. S., "Long non-coding RNAs : definitions, functions, challenges and recommendations", Nat. Rev. Mol. Cell Biol, 24, pp.430~447 (2023)
- Loe, A. K. H., "Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis", Exp. Mol. Med, 55, pp.22~31 (2023)
- Ju, M., "Circular RNAs in and out of cells : therapeutic usages of circular RNAs", Mol. Cells, 46, pp.33~40 (2023)
- Kristensen, L. S., "The biogenesis, biology and characterization of circular RNAs", Nat. Rev. Genet, 20, pp.675~691 (2019)
- Yang, S., "Molecular insights into regulatory RNAs in the cellular machinery", Exp. Mol. Med, 56, pp.630~645 (2024)[DOI]
- Lee, K., "Inverted alu repeats: friends or foes in the human transcriptome", Exp. Mol. Med, 84, pp.1062~1077 (2024)[DOI]
- Yap, X. L., "Elucidation of how the Mir-23-27-24 cluster regulates develop ment and aging", Exp. Mol. Med (2024)[DOI]
- Hwang, H. J., "Molecular mechanisms of circular RNA translation", Exp. Mol. Med (2024)[DOI]
- Choi, S., "Optimal design of synthetic circular RNAs", Exp. Mol. Med (2024)[DOI]
- Hwang, H., "Big data and deep learning for RNA biology", Exp. Mol. Med (2024)[DOI]