티타늄나노입자의 랫드 5일 반복 경구투여 후 배설, 조직분포 및 독성에 관한 평가연구
Excretion, Tissue Distribution and Toxicities of Titanium Oxide Nanoparticles in Rats after Oral Administration over Five Consecutive Days
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Objectives: Excretion and tissue distribution of titanium oxide nanoparticles were evaluated in rats after oraladministration. The relation between toxicity and systemic concentration of nanoparaticles was investigated. Methods: Rats were orally treated with titanium oxide nanoparticles (10, 100 mg/kg) for five consecutive days. General toxicity, blood chemistry, and serum biochemical analysis were analyzed. Titanium concentration inliver, kidney, lung, urine and feces were measured and histopathology was performed in these organs. Results: Induction of toxicological parameters was not observed and titanium nanoparticles were excreted viafeces. Conclusion: Absorption of titanium oxide nanoparticles via the gastrointestinal tract after oral administrationwas very poor and systemic concentration of titanium oxide nanoparticles was not elevated. Titanium oxidenanoparticles did not cause toxicities in rats after oral administration.
Abstract
Objectives: Excretion and tissue distribution of titanium oxide nanoparticles were evaluated in rats after oraladministration. The relation between toxicity and systemic concentration of nanoparaticles was investigated. Methods: Rats were orally treated with titanium oxide nanoparticles (10, 100 mg/kg) for five consecutive days. General toxicity, blood chemistry, and serum biochemical analysis were analyzed. Titanium concentration inliver, kidney, lung, urine and feces were measured and histopathology was performed in these organs. Results: Induction of toxicological parameters was not observed and titanium nanoparticles were excreted viafeces. Conclusion: Absorption of titanium oxide nanoparticles via the gastrointestinal tract after oral administrationwas very poor and systemic concentration of titanium oxide nanoparticles was not elevated. Titanium oxidenanoparticles did not cause toxicities in rats after oral administration.
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