산화알루미늄 나노물질이 랫드의 대뇌와 신장에 미치는 영향
Toxic Effects of Alumina Nanoparticles in Rat Cerebrums and Kidneys
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Objectives: Alumina nanoparticles (Al2O3, Al-NPs) are used for various purposes, including as coating agentsand paint additives. Their potential toxicity has raised concern for human health. This study focuses on exploringthe toxic effects on the brain and kidneys caused by Al-NPs exposure in rats. Methods: The animals were orally administered Al-NPs at 10, 50 and 100 mg/kg body weight for 28 daysfollowing OECD TG 407. To determine the targeted toxicity of Al-NPs, histopathological examination and geneexpression analysis were conducted on the rats. Results: The Al-NPs treatment induced kidney tubular dilatation. In the rat cerebrums, the expressionlevels of 126 genes experienced two-fold or greater increases in response to Al-NPs, including othergenes encoding proteins involved in cell differentiation, transcription and signal transduction. In the ratkidneys, the expression levels of 152 genes also showed two-fold or greater increases in response to Al-NPs, including other genes encoding proteins involved in apoptosis, transcription and signaltransduction. Conclusion: These results suggest that exposure to Al-NPs influences cellular signal pathways of kidney andcerebrum, and it can be a toxic indicators of nanometrials.
Abstract
Objectives: Alumina nanoparticles (Al2O3, Al-NPs) are used for various purposes, including as coating agentsand paint additives. Their potential toxicity has raised concern for human health. This study focuses on exploringthe toxic effects on the brain and kidneys caused by Al-NPs exposure in rats. Methods: The animals were orally administered Al-NPs at 10, 50 and 100 mg/kg body weight for 28 daysfollowing OECD TG 407. To determine the targeted toxicity of Al-NPs, histopathological examination and geneexpression analysis were conducted on the rats. Results: The Al-NPs treatment induced kidney tubular dilatation. In the rat cerebrums, the expressionlevels of 126 genes experienced two-fold or greater increases in response to Al-NPs, including othergenes encoding proteins involved in cell differentiation, transcription and signal transduction. In the ratkidneys, the expression levels of 152 genes also showed two-fold or greater increases in response to Al-NPs, including other genes encoding proteins involved in apoptosis, transcription and signaltransduction. Conclusion: These results suggest that exposure to Al-NPs influences cellular signal pathways of kidney andcerebrum, and it can be a toxic indicators of nanometrials.
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