흡입된 나노입자와 건강: 고찰
Inhaled Nanoparticles and Occupational Health: A Review
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In many fields, nanotechnology is leading to the development of purposely-engineered nanoparticles and devices demonstrating new, unique and non-scalable properties. However, concern has been expressed that these same properties may present unique challenges in terms of the potential health impact. Airborne particles associated with engineered nanoparticles are of particular concern, as they can readily enter the body through inhalation. Research into the potential occupational health risks associated with inhaling engineered nanoparticles is actively being conducted in the U.S. and globally. In this article, the potential occupational health effects of inhaled nanoparticles and methods for measuring exposure to nanoparticles are discussed. Critical research needs in this field are also briefly addressed.
Abstract
In many fields, nanotechnology is leading to the development of purposely-engineered nanoparticles and devices demonstrating new, unique and non-scalable properties. However, concern has been expressed that these same properties may present unique challenges in terms of the potential health impact. Airborne particles associated with engineered nanoparticles are of particular concern, as they can readily enter the body through inhalation. Research into the potential occupational health risks associated with inhaling engineered nanoparticles is actively being conducted in the U.S. and globally. In this article, the potential occupational health effects of inhaled nanoparticles and methods for measuring exposure to nanoparticles are discussed. Critical research needs in this field are also briefly addressed.
참고문헌 (39)
- Oberdörster, G, "Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy", Particle and Fibre Toxicology, 2(8), pp.1186~1743 (2005)
- Maynard, A. D, "Responsible nanotech at work. Nanotoday.A Materials Today Suppliment", ~ (2004)
- "The Space Elevator"[URL]
- Shvedova, A. A, "Unusual inflammatory and fibrogenic pulmonary responses to single walled carbon nanotubes in mice", American Journal of Physiology - Lung Cellular and Molecular Physiolog, 289, pp.698~708 (2005)
- Lam, C. W., "Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation", Toxicological Sciences, 77, pp.126~134 (2004)
- Roco, M. C, "Environmentally responsible development of nanotechnology", Environmental Science &Technology, 39(5), pp.106~112 (2005)
- Maynard,A.D, "Airborne nanostructured particles and occupational health", Journal of Nanoparticle Research, 7, pp.587~614 (2005)
- Oberdörster, G, "Translocation of inhaled ultrafine particles to the brain", Inhalation Toxicology, 16, pp.437~445 (2004)
- Oberdörster, G, "Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats", Journal of Toxicology and Environmental Health A, 65, pp.1531~1543 (2002)
- Tran, C. L, "Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance", Inhalation Toxicology, 12, pp.1113~1126 (2000)
- Brown, D. M, "Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines", Toxicology and Applied Pharmacology, 175(3), pp.191~199 (2001)
- Duffin, R, "The importance of surface area and specific reactivity in the acute pulmonary inflammatory response to particles", Annals of Occupational Hygiene, 46, pp.242~245 (2002)
- Renwick, L. C, "Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particles", Occupational and Environmental Medicine, 61, pp.442~447 (2004)
- Barlow, P. G, "Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages", Particle and Fibre Toxicology, 2(11), pp.1~14 (2005)
- Oberdörster, G, "Correlation between particle size, in vivo particle persistence,and lung injury", Environmental Health Perspectives, 102(5), pp.173~179 (1994)
- Sayes, C, "The differential cytotoxicity of water-soluble fullerenes", Nano Letters, 4, pp.1881~1887 (2004)
- Poland, C. A, "Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study", Nature Nanotechnology, 3(7), pp.423~428 (2008)
- Takagi, A, "Induction of mesothelioma in p53+", - mouse by intraperitoneal application of multi-walled carbon nanotube, 2008, pp.33, 105~116
- "NIOSH Document.Approaches to Safe Nanotechnology:An Information Exchange with NIOSH"[URL]
- [URL]
- Ku,B.K, "Comparing aerosol surface-area measurement of monodisperse ultrafine silver agglomerates using mobility analysis, transmission electron microscopy and diffusion charging", Journal of Aerosol Science, 36, pp.1108~1124 (2005)
- Ku, B. K, "Determination of the ratio of diffusion charging based surface area to geometric surface area for spherical particles in the size range of 100-900 nm", Journal of Aerosol Science, 41(9), pp.835~847 (2010)
- Fissan, H, "Rationale and principle of an instrument measuring lung deposited nanoparticle surface area", Journal of Nanoparticle Research, 9, pp.53~59 (2007)
- Ku, B. K, "In situ structure characterization of airborne carbon nanofibers by a tandem mobility-mass analysis", Nanotechnology, 17, pp.3613~3621 (2006)
- Maynard, A. D, "Measuring particle size-dependent physicochemical structure in airborne single walled carbon nanotube agglomerates", Journal of Nanoparticle Research, 9, pp.85~92 (2007)
- Evans, D. E, "Aerosol monitoring during carbon nanofiber production:Mobile direct-reading sampling", The Annals of Occupational Hygiene, 54(4), pp.514~531 (2010)
- Bello, D, "Exposure to nanoscale particles and fibers during machining of hybrid advanced composites containing carbon nanotubes", Journal of Nanoparticle Research, 11, pp.231~249 (2009)
- Heitbrink, W. A, "Relationship among particle number, surface area, and respirable mass concentration in an automotive engine manufacturing", Journal of Occupational and Environmental Hygiene, 6, pp.19~31 (2009)
- Evans, D. E, "Ultrafine and respirable particles in an automotive grey iron foundry", The Annals of OccupationalHygiene, 52, pp.9~21 (2008)
- Han, J. H, "Monitoring multiwalled carbon nanotube exposure in carbon nanotube research facility", Inhalation Toxicology, 20, pp.741~749 (2008)
- Maynard, A. D, "Assessing exposure to airborne nanomaterials: Current abilities and future requirements", Nanotoxicology, 1(1), pp.26~41 (2007)
- "NIOSH Health Hazard Evaluation Report. HETA #2005-0291-3025. University of Dayton Research Institute (UDRI), Dayton Ohio"[URL]
- Mazzuckelli, L. F, "Case study: Identification and characterization of potential sources of worker exposure to carbon nanofibers during polymer composite laboratory operations", Journal of Occupational and Environmental Hygiene, 4(12), pp.125~130 (2007)
- Maynard, A. D, "Safe handling of nanotechnology", Nature, 444, pp.267~269 (2006)
- "U.S. Environmental Protection Agency. Nanomaterial research strategy", Office of Research and Development, U.S. Environmental Protection Agency. EPA 620, 011, pp.2009, ~
- Hirst, N, "Containment systems: a design guide. Warwickshire, UK:Institution of Chemical Engineers (IChemE)", ~ (2002)
- "ACGIH : Industrial ventilation: a manual of recommended practice" (2007), 26th edn. Cincinnati, OH. ACGIH Signature Publications
- Old, L, "Engineering case report: effectiveness of local exhaust ventilation (LEV) in controlling engineered nanomaterial emissions during reactor cleanout operations", Journal of Occupational and Environmental Hygiene, 5, pp.D63~D69 (2008)
- Ku, B. K, "Observation and measurement of anomalous responses in a differential mobility analyzer caused by ultrafine fibrous carbon aerosols", Journal of Electrostatics, 65(8), pp.542~548 (2007)
