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ICR mouse 에 있어 UVB조사로 유도된 접촉 과민반응에 대한Egb 761의 억제효과

Prevention of Ultravilot B Radiation(280-320 nm) InducedContact Hypersensitivity by Egb 761

안형수|안령미|최욱희
한국환경보건학회 (Korean Society of Environmental Health)|2005.03|한국환경보건학회지 (JOURNAL OF ENVIRONMENTAL HEALTH SCIENCES)|제31권 제1호|pp. 7-14

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Abstract

Exposure of skin to UVB radiation can cause the induction of inflammation and impairment of contact hypersensitivity(CHS) response. Several studies have shown that polyphenolic compounds isolated from EGb 761 afford protection against UVB. In this study, we demonstrated that topical application of EGb 761, before 1MED(1.4 KJ/m2), 1.5MED (2.1 KJ/m2), 2MED (2.8 KJ/m2) of UVB exposure to ICR mice prevented UVB-induced inflammation and inhibition of the contact hypersensitivity response. The skin-fold swelling from 1MED, 1.5MED, 2MED of UVB exposure highly significantly increased after twice irradiation. Topical application of EGb 761(0.1%, 1%, 4%), 5 days prior to UVB exposure reduced skin thickness compared to non-treated mice. Exposure of shaved abdominal skin of mice to 1MED, 1.5MED and 2MED of UVB radiation resulted in suppression of contact sensitization through the skin to 56.23%, 65.12%, 74.02%, compared to normal unirradiated skin. Topical application of EGb 761(0.1%, 1%, 4%), 5 days prior to or 5 days after exposure to 1MED and 2MED of UVB resulted in protection against suppression of contact hypersensitivity in mouse dorsal skin. These protective effects were dependent on the dose of EGb 761 employed. The present study show that EGb 761 protect UVB-induced inflammation and immune suppression. Also, we suggest that EGb 761 can provide protection from photoimmunosuppression.

참고문헌 (24)

  1. "Effect of ultraviolet radiation on the skin", 20(3), pp.181~186 (1995)
  2. "아크용접 작 업 중 발생하는 자외선 노출에 관한 연구", 25(4), pp.51~58 (1999)
  3. "실시간 교통량을 이용한 고 속도로 요금소 대기오염도 예측", 26(4), pp.134~140 (2000), 한국환경보건학회
  4. "부산지역의 입자상 대기오염 물질의 농도특성에 관한 연구", 26(2), pp.41~48 (2000), 한국환경보건학회
  5. "protects hairless mice from immunosuppression induced by ultraviolet B radiation", 115, pp.280 316~322 (1998)
  6. "The mechanism of immune responses and T cell balance Journal of Interferon and Cytokine Research", 22, pp.407~412 (2002)
  7. "a-tocopherol an inhibitor of epidermal lipid peroxidation protects ultraviolet radiation from suppressing the skin immune system", 85(3), pp.587~92 (1997)
  8. "Vitamin C abrogates the deleterious effects of UVB radiation on cutaneous immunity by a mechanism that does not depend on TNF-alpha", 109(1), pp.20~4 (1997)
  9. "protects from the suppression of contact hypersensitivity by ultraviolet B radiation or by cis urocanic acid", m and rozi car immu(va sine logy), pp.280 99~104 (1993)
  10. "Protection of UV-induced suppression of skin contact hypersensitivity a common feature of flavonoids after oral administration", 67(4), pp.456~61 (1998)
  11. "Protection against ultraviolet-B radiation-induced local and systemic suppression of contact hypersensitivity and edema response in C3H", HeN mice by green tea polyphenols, 1995, pp.62(5), 855~61
  12. "자외선 B파로 유도 된 Hairless mouse의 과산화지질 및 항산화 효소활성 도와 탄닌의 효과", 22(4), pp.102~118 (1996)
  13. "Ultraviolet radiation and the contact hypersensitivity reaction in mice", 28, pp.20~24 (2002)
  14. "Inhibition of human p450 enzymes by multiple constituents of the Ginkgo biloba extract", 318, pp.1072~1078 (2004)
  15. "Efficiency of Ginkgo biloba extract in antioxidant protection against myocardial ischemia and reperfusion injury", 35(1), pp.125~761 34 (1995)
  16. "Effects of Ginkgo biloba extract on the cellular immune response in a hypothalamic-pituitary- adrenal axis activation model in the rat", 3, pp.75~761 80 (2003)
  17. "Antioxidant flavonoids from leaves of Polygonum hydropiper L", 62, pp.219~228 (2003)
  18. "Effects of Ginkgo biloba extract on hydroxyl radical induced thymocyte apoptosis and on age related thymic atrophy and peripheral immune dysfunctions in mice Mechanisms of Ageing and Development", 124, pp.977~761 983 (2003)
  19. "Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components International Journal of Immunopharmacology", 21, pp.303~310 (1999)
  20. "A garlic extract protects from ultraviolet B radiation-induced suppression of contact hypersensitivity", rozi(va), pp.280 813~817 (1993)
  21. "Indomethacin 투여가 마우스의 접촉 과민 반응에 미치는 영향", 28(3), pp.278~282 (1990)
  22. "The protective effect of indomethacin on photocarcinogenesis in hairless mice", 95, pp.213~219 (1995)
  23. "Protection from inflammation immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol", 79(2), pp.193~8
  24. "UV-induced skin damage.", 189, pp.21~39 (2003)

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