黃連解毒湯이 알러지성 접촉피부염에 미치는 영향 - 알러지성 접촉피부염 유발로 손상된 생쥐 상피세포의 완화를 중심으로
The Effects of Hangryunhaedocktang on Allergic Contact Dermatitis Based on the Morphological Changes in Epidemal Damage in Mice
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Abstract
This study was performed to investigate the effectiveness of Hangryunhaedocktang (HHT) on epidermal damages induced by allergic contact dermatitis (ACD). The sensitization were caused by one application of 25 ㎕ of 5% 2,4-dinitrochlorobenzene (DNCB) onto a back-lumbar skin of BALB/c mice. 2 weeks later, ACD was elicitated with 4 ㎕ of 2.5% DNCB and then mice were given HHT extract in doses of 3.3 ㎖/㎏/day, for 72 hours. The ACD induced epidermal damages in HHT treated ACD mice was more mitigated than non-treated ACD elicited mice. The features related with epidermal damage such as epidermal hyperplasia, infiltration of inflammatory cells, increase of nuclear shrinkages and vacuolation, and enlargement of intercellular space softened. And the distribution of soybean agglutinin (SBA) positive reaction in stratum spinosum (SS) and stratum basale (SB) were similarly maintained in a normal configuration. The numerical decrease of BrdU, TUNEL, and Fas positive cells observed were prominent in SB. Results suggest a benefit role for HHT in mitigating epidermal damages in mice with allergic contact dermatitis.
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