소풍산물추출물이 DNCB로 유발된 접촉성피부염에 미치는 영향
Effect of Sopung-san on Contact Hypersensitivity induced by Repeat Elicitation of DNCB
1
조회
0
다운로드
10
인용
0
참고문헌
초록
Abstract
Sopung-san(SPS; prescription No. D027), a herbal medicine prescribed by oriental hospital of Daegu Hanny University, has been used as cure for pruritus and psoriasis. To evaluate anti-inflammatory effect of Sopung-san, we treated Sopung-san extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/c mouse. Sopung-san was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatment, but a mouse ear thickness was significantly reduced by Sopung-san after 2 weeks treatment. Sopung-san reduced IgG in serum obtained from blood of 1% DNCB-treated mouse. IgE in serum was not changed by DNCB and/or Sopung-san treatment. IL-1β and IL-6 from ear tissue were significantly increased by DNCB, but were not reduced by Sopung-san. From these results, anti-inflammatory effect of Sopung-san, especially reduction of ear swelling, might be partly due to reduction of IgG in serum.
참고문헌 (32)
- 김창환, "凉血四物湯加味方이 Allergy性 接觸 皮膚炎에 미치는 影響", 한방안이비인후피부과학회지, 18(1), pp.13~26 (2005), 대한한방안이비인후피부과학회
- 김윤범, "접촉성 피부염에 대한 한방적 고찰", 5(1), pp.113~120 (1992)
- 전재홍, "접촉성 피부염에 관한 문헌적 고찰", 10(1), pp.263~283 (1997)
- 김만식, "Allergy성 접촉 피부염이 유발된 백서의 손상피부에 熱多寒少湯 전탕액이 미치는 영향", 14(3), pp.97~113 (2002)
- 김호연, "連翹敗毒散加味方이 알러지성 접촉 피부염에 미치는 영향 2- 알러지성 접촉 피부염 유발로 손상된 생쥐 상피세포 완화를 중심으로", 13(3), pp.67~81 (2001)
- 권오성, "連翹敗毒散加味方이 알러지성 접촉 피부염에 미치는 영향", pp.77~91 (1999)
- 조세앙, "凉膈散火湯이 Allergy성 접촉 피부염에 미치는 영향", 13(3), pp.89~101 (2001)
- 신광식, "生地黃 추출물이 DNCB로 유도된 생쥐의 Allergy성 접촉피부염에 미치는 영향", pp.257~280 (2000)
- 권종훈, "梔子 추출물이 DNCB로 유도된 생쥐의 Allergy성 접촉 피부염에 미치는 영향", 20(2), pp.105~119 (1999)
- 김찬중, "Allergy성 접촉피부염에 대한 고삼 황련의 Iontophoresis 치료 효과" (2005)
- 정규만, "알레르기와 한방", pp.90~92 (1990)
- Stricker, "a new treatment approach to AIDS" (1991)
- Fabre, "ATPase and morphologic changes in Langerhans cells induced by epicutaneous application of a sensitizing dose of DNFB", pp.689~694 (1989)
- Hill, "Systemic migration of dendritic cells during contact sensitization", immu(logy), pp.277~281 (1990)
- Botham, "The hapten in contact hypersensitivity to dinitrochlorobenzene", t immu(electron microscopic and immufluorescent studies), pp.126~130 (1989)
- Bang, "The distribution of 2 4-dinitrophenyl groups on Thy-1 positive cells in the epidermis of mouse following skin painting with 2", jin, pp.4 27~31 (1988)
- 周珉, "過敏性疾病的中醫治療", pp.250~255 (1995), 上海中醫藥大學出版社
- 박성남, "소풍산이 BALB", c mouse를 이용한 Atopy 피부염 Model에 미치는 영향, 2004, pp.20(2), 129~141
- 윤수영, "소풍산과 가미소풍산의 효능에 대한 실험적 연구", 5(2), pp.129~141 (1989)
- 민영규, "소풍산가미방과 외치방 병용이 NC", Nga 아토피 생쥐에 미치는 영향, 2005, 116~134
- 이준성, "消風散加味의 抗알레르기 효과에 관한 실험적 연구", 14(2), pp.9~20 (2001)
- 서형식, "소풍산의 Allergy 억제 효능에 관한 연구", 13(1), pp.22~29 (2000)
- 강석영, "알레르기질환의 진단과 치료", pp.253~254 (1993)
- Nakada, T.,, "Effect of orally administered Hochu-ekki-to on contact hypersensitivity caused by repeated application of antigen", int immu(pharmacol), pp.901~911 (2002)
- Farraj, A.K.,, "Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A", J mice, 2004, 315~325
- Albers, R.,, "Effects of supplementation with vitamins A and zinc on immune function in a murine sensitization model", pp.11 940~12 946 (2003)
- G.J. Gleich, "Bronchial asthma: Lessons from murine models", pp.2101~2102 (1997)
- ROB, C, "Specific IgE and IgG Responses in Atopic versus Nonatopic Subjects", pp.~127 (2000)
- Miyajima, I.,, "Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII Assessment of the cardiopulmonary changes and death associated with active or IgE- or IgG1-dependent passive anaphylaxis", pp.901~914 (1997)
- Delgado, A.V.,, "Production of tumor necrosis factor-alpha and interleukin 6 by rat leukocyte subpopulations after exposure to substance P", pp.355~2 361 (2003)
- Lee, Y.S.,, "Pro-inflammatory cytokine gene expression and nitric oxide regulation of aqueous extracted Astragali radix in RAW 264", j eth(pharmacol), pp.7 289~294 (2005)
- Lee, Y.S.,, "Pro-inflammatory cytokine gene expression and nitric oxide regulation of aqueous extracted Astragali radix in RAW 264", j eth(pharmacol), pp.7 289~294 (2005)