2011-2012절기 B형 인플루엔자 감염의 임상 양상
The Clinical Characteristics of Influenza B Infection during the 2011-2012 Influenza Season
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목 적:국내 B형 인플루엔자의 임상 양상 및 A형 인플루엔자와 비교를 위해 후향적 연구를 시행하였다. 방 법: 2011-2012 인플루엔자절기에 multiplex PCR 로 인플루엔자가 진단된 소아청소년 입원 환자들의 의무기록 분석으로 B형 인플루엔자의 임상 양상과 함께 같은기간 A형 인플루엔자와의 차이점을 조사하였다. 결 과:연구 기간 동안 진단 된 145명 인플루엔자 환자 중, A형 인플루엔자 66명, B형 인플루엔자 78명이 있었고, 1명은 A, B형 인플루엔자가 동시에 진단되었다. 이들은 기침(88.2%), 콧물(77.1%), 가래(60.4%) 등 호흡기 증상을 호소하며, 하기도 감염(49.3%) 및 상기도 감염(31.9%)으로 진단된 경우가 많았다. B형과 A형 인플루엔자 환자의 주요 증상 및 검사실 소견은 차이가 없었고, A형에 비해 B형 인플루엔자 환자의 입원 전 발열기간이 길었다(3.0일 vs. 2.5일, P=0.043). 결 론:임상 양상만으로 B형과 A형 인플루엔자 감별은제한성이 있고, B형 인플루엔자 환자의 입원 전 발열 기간 3일을 고려한다면 진단 후 치료보다 감염 전 예방이중요하다.
Abstract
Purpose: This retrospective study was performed to identify the clinical characteristics of influenza B infection and compare to influenza A infection. Methods: Medical records of patients diagnosed with influenza using a multiplex PCR test, admitted to Seoul St. Mary’s Hospital, during the 2011-2012 influenza season were analyzed. Clinical and laboratory characteristics of influenza B patients were investigated and compared with those of influenza A patients. Results: A total of 145 influenza patients were enrolled during this study period. Among these, 66 and 78 patients were diagnosed with influenza A and B, respectively, and 1 patient was diagnosed with co-existing influenza A and B. Cough (88.2%), rhinorrhea (77.1%) and sputum (60.4%) were the most common symptoms among these influenza patients, and most were diagnosed with upper respiratory infection (31.9%) or lower respiratory infection (49.3%). In comparison to influenza A patients, influenza B patients were older (4.7±4.1 years vs. 3.3±2.5 years, P =0.016), and the number of fever days before hospitalization were longer (3.0 days vs. 2.5 days, P =0.043). While sore throat (10.3% vs. 1.5%, P =0.039) and vomiting (20.5% vs. 6.1%, P =0.012) were more common in influenza B patients than in influenza A patients, other clinical and laboratory characteristics were not significantly different between the two groups. Conclusions: No significant differences in clinical and laboratory perspectives were manifested in influenza A and B infections. Preventive measures should be emphasized over treatment in influenza B due to prolonged fever duration before admission.
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