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루프스 신염 치료로 Cyclosporine 투여 후 발생한 가역성후백질뇌병증 증후군

A case of Reversible Posterior Leukoencephalopathy Syndrome in Lupus Nephritis Treated with Cyclosporine

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초록

Reversible posterior leukoencephalopathy syndrome (RPLS) is an acute encephalopathy, usually characterized by seizures, visual disorder, mental change and reversible posterior white and gray matter lesions on brain magnetic resonance imaging (MRI). Conditions commonly associated with RPLS include acute renal failure, eclampsia, hypertension, immunosuppresion state, and use of intravenous immunoglobulin or chemotherapy, and additional contributing factors. We report the case of RPLS associated with cyclosporine use in lupus nephritis. In this case, it was not clearly elucidated which was main cause of RPLS. We could think RPLS developed maybe due to combined effect of cyclosporine and lupus nephritis

Abstract

Reversible posterior leukoencephalopathy syndrome (RPLS) is an acute encephalopathy, usually characterized by seizures, visual disorder, mental change and reversible posterior white and gray matter lesions on brain magnetic resonance imaging (MRI). Conditions commonly associated with RPLS include acute renal failure, eclampsia, hypertension, immunosuppresion state, and use of intravenous immunoglobulin or chemotherapy, and additional contributing factors. We report the case of RPLS associated with cyclosporine use in lupus nephritis. In this case, it was not clearly elucidated which was main cause of RPLS. We could think RPLS developed maybe due to combined effect of cyclosporine and lupus nephritis

참고문헌 (10)

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  2. Primavera A, "Reversible posterior leucoencephalopathy syndrome in systemic lupus and vasculitis", Ann Rhem Dis, 60, pp.534~537 (2001)
  3. 박민찬, "Reversible Posterior Leukoencephalopathy Syndrome과 동반된 전신성 홍반성 루푸스 1예", 대한류마티스학회지, 9(4), pp.13~340 (2002), 대한류마티스학회
  4. Shin KC, "Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine", J Clin Rheumatol, 11, pp.164~166 (2005)
  5. Magnano MD, "Reversible posterior leukoencephalopathy in patients with systemic lupus erythematosus", Semin Arthritis Rhem, 35, pp.396~402 (2006)
  6. Min L, "Reversible posterior leukoencephalopathy in connective tissue diseases", Semin Arthritis Rheum, 35, pp.385~395 (2006)
  7. Sheth RD, "Parietal occipital edema in hypertensive encephalopathy: a pathogenic mechanism", Eur Neurol, 36, pp.25~28 (1996)
  8. Jennekens FG, "The central nervous system in systemic lupus erythematosus. Part 1. Clinical syndromes: a literature investigation", Rheumatology (Oxford), 41, pp.605~618 (2002)
  9. Leroux G, "Posterior reversible encephalopathy syndrome during systemic lupus erythematosus: four new cases and review of the literature", Lupus, 17, pp.139~147 (2008)
  10. Covarrubias DJ, "Posterior reversible encephalopathy syndrome: prognostic utility of quantitative diffusion-weighted MR images", AJNR Am J Neuroradiol, 23, pp.1038~1048 (2002)

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