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스테로이드 저항성 신증후군 환아에서 사이클로스포린 투여 중 발생한 후두엽 가역성 뇌병증 증후군 1례

A Case of Posterior Reversible Encephalopathy Syndrome during Cyclosporine Therapy in a Child with Steroid Resistant Nephrotic Syndrome

염미선|박영서|이주훈|정민희|고태성
대한소아신장학회 (The Korean Society Of Pediatric Nephrology)|2007.04|Childhood Kidney Diseases (Childhood Kidney diseases)|제11권 제1호|pp. 92-99

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참고문헌

주제분류소아과학

초록

두엽 가역성 뇌병증 증후군은 고혈압, 자간증, 신부전으로 인한 고혈압 및 면역억제약물 등의 병력과 함께 두통, 구토, 경련, 시야장애 등 임상적 증상을 보이고 뇌 자기공명영상에서 특징적인 소견을 보이는 질환군이다. 저자들은 스테로이드 저항성 신증후군 환아에서 사이클로스포린 투여 중 발생한 후두엽 가역성 뇌병증 증후군을 경험하였기에 보고하는 바이다.

Abstract

The posterior reversible encephalopathy syndrome(PRES) is characterized clinically by a combination of acute or subacute confusion, lethargy, visual disturbance, and seizures. PRES has been described in various clinical settings, including severe hypertension, chemotherapy, eclampsia, and seizure. We report a case of a 7-year-old girl who had taken cyclosporine for steroid resistant nephrotic syndrome. Twenty one days after the cyclosporine therapy, she was admitted due to generalized tonic clonic seizure and headache. Her blood pressure was 170/90 mmHg. Magnetic resonance(MR) imaging showed necrotic/cystic lesions involving the bilateral parieto-occipital region. After discontinuation of cyclosporine, and control of blood pressure, she had no more seizure and headache. The follow-up MR examination which was performed 6 months later showed the decreased extent of the lesion.

참고문헌 (35)

  1. "Pathogenesis of edema formation in the nephrotic syndrome", 16, pp.283~293 (2001)
  2. "Conditions particularly associated with proteinuria", pp.1751~1757 (2004), Philadelphia: W.B. Saunders Co
  3. "Evaluation and management of proteinuria and nephrotic syndrome in children: recommendations from a pediatric nephrology panel established at the National Kidney Foundation conference on proteinuria, albuminuria, risk, assessment, detection, and elimination", 105, pp.1242~1249 (2000)
  4. "Cyclosporin A acute encephalopathy and seizure syndrome in childhood: clinical features and risk of seizure recurrence", 13, pp.336~344 (1998)
  5. "Nephrotic syndrome in children", 122, pp.13~28 (2005)
  6. "Neural actions of immunophilin ligands", 19, pp.21~26 (1998)
  7. "Neurologic complications of immunosuppressive agents", pp.261~78
  8. "a review and its specific use in liver transplantation", pp.680~9
  9. "Causes and outcome of seizures in liver transplant recipients", 47, pp.1523~1525 (1996)
  10. "Neurologic complications in allogeneic bone marrow transplant patients receiving cyclosporin", pp.393~401, Bone Marrow Transplant 1991; 8
  11. "Neurological complications of organ transplantation", pp.688~703
  12. "A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group", 63, pp.977~983 (1997)
  13. "FK506(tacrolimus) compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Results from the U.S. Multicenter Trial", 59, pp.530~536 (1995)
  14. "Convulsions associated with cyclosporin A in renal transplant recipients", pp.139~40 (1985)
  15. "Complex partial status epilepticus associated with cyclosporin A therapy", pp.1068~71
  16. "Occipital lobe seizures as the major clinical manifestation of reversible posterior leukoencephalopathy syndrome: magnetic resonance imaging findings", 39, pp.295~299 (1998)
  17. "late occurrence of severe neurotoxicity in a liver transplant recipient", pp.176~8
  18. "Cyclosporine-associated central-nervous-system toxicity after allogeneic bone-marrow transplantation"
  19. "Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity", 22, pp.1901~1914 (2001)
  20. "Cyclosporine neurotoxicity and its relationship to hypertensive encephalopathy: CT and MR findings in 16 cases", 165, pp.627~631 (1995)
  21. "Acute cyclosporine-induced renal vasoconstriction is mediated by endothelin-1", pp.480~
  22. "Cyclosporine neurotoxicity: a review", 246, pp.339~346 (1999)
  23. "Evidence that cyclosporine causes both intracellular migration and inappropriate urinary excretion of magnesium in rats", (zue t), pp.346~9
  24. "Association between cyclosporin neurotoxicity and hypomagnesaemia", pp.1116~20
  25. "Contractile and endothelium- dependent dilatory responses of cerebral arteries at various extracellular magnesium concentrations", pp.161~4
  26. "A reversible posterior leukoencephalopathy syndrome", 334, pp.494~500 (1996)
  27. "Posterior leukoencephalopathy syndrome", 77, pp.24~28 (2001)
  28. "Diffusion MR findings in cyclosporin-A induced encephalopathy", 46, pp.822~824 (2004)
  29. "Cortical blindness: clinical and radiologic findings in reversible posterior leukoencephalopathy syndrome: case report and review of the literature", 112, pp.e7~e11 (2005)
  30. "Watershed imaging features and clinical vascular injury in cyclosporin A neurotoxicity", 21, pp.872~880 (1997)
  31. "Cyclosporin-associated akinetic mutism and extrapyramidal syndrome after liver transplantation", pp.1068~71
  32. "Cyclosporin neurotoxicity in cardiac transplant recipients", pp.1434~7
  33. "Posterior reversible encephalopathy syndrome in children with cancer", 48, pp.152~159 (2007)
  34. "A case of reversible posterior leukoencephalopathy syndrome during methylprednisolone pulse and cyclophosphamide therapy in a child with nephrotic syndrome", 9, pp.245~250 (2005)
  35. "Acute leukoencephalopathy during cyclosporin A therapy in a pediatric patient with nephrotic syndrome", 9, pp.91~96 (2005)

관련 논문AI추천

신증후군 환자에서 스테로이드 충격요법과 경구용 면역억제제 치료 중 발생한 가역성 후백질뇌병증 1례김지홍, 서주희, 신정욱, 윤춘식대한소아신장학회 · Childhood Kidney Diseases2005 · 제9권 제2호신 증후군 환아에서 Cyclosporin A 치료 중 발생한 급성 백색질 뇌증 1례권영세, 김순기, 손병관, 이경화, 이지은, 정석원대한소아신장학회 · Childhood Kidney Diseases2005 · 제9권 제1호A군 사슬알균 감염 후 사구체신염 환아에서 발생한 가역적 후두부 뇌병증 증후군 1례강진한, 마상혁, 이은경대한소아감염학회 · Pediatric Infection and Vaccine2015 · 제22권 제2호소아에서 발생한 연쇄구균 감염 후 사구체 신염에 의한 가역성 후두부 뇌병증 증후군 1례김기혁, 윤봉식, 이수진, 정희정, 김유리아대한소아신경학회 · 대한소아신경학회지2008 · 제16권 제2호Posterior Reversible Encephalopathy Syndrome Accompanied by a Cerebral Hemorrhage and Restricted Diffusion in a Child with Uncontrolled Nephrotic Syndrome김혜정, 안요한, 이건희, 정승미, 최성은대한소아신경학회 · 대한소아신경학회지2017 · 제25권 제3호한국인 소아·청소년에서 가역성 후두부 백질 뇌증 증후군의 임상적 특성에 대한 다기관 공동연구권순학, 김선준, 김원섭, 남상욱, 서혜은, 이은주, 황수경대한소아신경학회 · 대한소아신경학회지2009 · 제17권 제2호

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