간질환자 두피뇌파의 발작사이간질모양방전과 배경파 델타영역: 전류원분포의 해부학적 연관성
Interictal Epileptiform Discharges and Background Delta Frequency Bands in Scalp EEGs of Epileptic Patients: Anatomical Correlation between the Current Source Distributions
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: The intermittent delta activity in electroencephalographies (EEGs) of patients with focal brain lesions has been reported to be a marker of an epileptogenic focus. This study investigated the concordance between the current source distribution (CSD) of the interictal epileptiform discharges (IEDs) and that of the background delta frequency bands (DFBs) of the scalp EEG. Methods: We collected scalp EEGs of 13 patients with focal epilepsy that contained uniregional IEDs and unilateral delta to theta slow waves. We applied a distributed source model using LORETA® to determine the CSD of the peak points of the IEDs and the DFBs of the background activity. Results: The CSDs of the DFBs were ipsilateral to the CSDs of the peak point of the averaged IEDs in ten patients, and bilateral with ipsilateral predominance in three patients. In the cases with an ipsilateral CSD of the DFB, 8 of 10 patients had concordance of the CSD localization between the averaged IED and the DFB. In the cases with bilateral CSD of the DFB, 2 of 3 patients had concordance of the CSD localization between the averaged IED and the DFB. Conclusions: The CSD localization and lateralization appear to be concordant between the IEDs and the DFB of background activity in epileptic patients. Therefore, the CSD of the DFB in EEGs with visually observable slow activities may predict those of IEDs.
Abstract
Background: The intermittent delta activity in electroencephalographies (EEGs) of patients with focal brain lesions has been reported to be a marker of an epileptogenic focus. This study investigated the concordance between the current source distribution (CSD) of the interictal epileptiform discharges (IEDs) and that of the background delta frequency bands (DFBs) of the scalp EEG. Methods: We collected scalp EEGs of 13 patients with focal epilepsy that contained uniregional IEDs and unilateral delta to theta slow waves. We applied a distributed source model using LORETA® to determine the CSD of the peak points of the IEDs and the DFBs of the background activity. Results: The CSDs of the DFBs were ipsilateral to the CSDs of the peak point of the averaged IEDs in ten patients, and bilateral with ipsilateral predominance in three patients. In the cases with an ipsilateral CSD of the DFB, 8 of 10 patients had concordance of the CSD localization between the averaged IED and the DFB. In the cases with bilateral CSD of the DFB, 2 of 3 patients had concordance of the CSD localization between the averaged IED and the DFB. Conclusions: The CSD localization and lateralization appear to be concordant between the IEDs and the DFB of background activity in epileptic patients. Therefore, the CSD of the DFB in EEGs with visually observable slow activities may predict those of IEDs.
참고문헌 (22)
- Gloor P, "Brain lesions that produce delta waves in the EEG", Neurology, pp.326~333 (1977)
- Reinikainen KJ, "CT brain scan and EEG in the diagnosis of adult onset seizures", Epilepsy Res, 1, pp.178~184 (1987)
- Nuwer MR, "Frequency analysis and topographic mapping of EEG and evoked potentials in epilepsy", Electroencephalogr Clin Neurophysiol, 69, pp.118~126 (1987)
- Gibbs J, "Focal electroencephalographic abnormalities and computerised tomography findings in children with seizures", J Neurol Neurosurg Psychiatry, 56, pp.369~371 (1993)
- Panet-Raymond D, "Asymmetry in delta activity in patients with focal epilepsy. Electroencephalogr", Neurophysiol, pp.474~481 (1990)
- Engel J JR, "Recent advances in surgical treatment of temporal lobe epilepsy", Neurol Scand Suppl, 86, pp.71~80 (1992)
- Reiher J, "Temporal intermittent rhythmic delta activity (TIRDA) in the diagnosis of complex partial epilepsy: sensitivity, specificity and predictive value", Can J Neurol Sci, pp.398~401 (1989)
- Di Gennaro G, "Localizing significance of temporal intermittent rhythmic delta activity (TIRDA) in drug-resistant focal epilepsy", Clinical Neurophysiology, 1
- Koles ZJ, "Trends in EEG source localization", Electroencephalography and Clin Neurophysiol, 106, pp.127~137 (1998)
- Kaltenhauser M, "Spatial intralobar correlation of spike and slow wave activity localisations in focal epilepsies: A MEG analysis", NeuroImage, 34, pp.1466~1472 (2007)
- Huppertz H-J, "Localization of interictal delta and epilepti form EEG activity associated with focal epileptogenic brain lesions", NeuroImage, 13, pp.15~28 (2001)
- Gambardella A, "Focal intermittent delta activity in patients with mesiotemporal atrophy: a reliable marker of the epileptogenic focus", Epilepsia, 36, pp.122~129 (1995)
- Anderer P, "Effect of the 5-HT1A partial agonist buspirone on regional brain electrical activity in man: a functional neuroimaging study using lowresolution electromagnetic tomography (LORETA)", Psychiatry Res: Neuroimaging, 100, pp.81~96 (2000)
- Abraham K, "Patterns of cortical discharges and their relation to routine scalp electroencephalography", Electroencephalogr Clin Neurophysiol, 10, pp.447~461 (1958)
- Marsan CA, "Considerations on the use of chronically implanted electrodes in seizure disorders", Confin Neurol (Basel), 27, pp.95~110 (1966)
- Cooper R, "Comparison of subcortical, cortical and scalp activity using chronically indwelling electrodes in man", Electroencephalogr Clin Neurophysiol, 18, pp.217~228 (1965)
- Tao JX, "Intracranial EEG substrates of scalp EEG interictal spikes", Epilepsia, 46, pp.669~676 (2005)
- de Jongh A, "The localization of spontaneous brain activity: first results in patients with cerebral tumors", Clin Neurophysiol, 112, pp.378~385 (2001)
- Pascual-Marqui RD, "Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain", Int J Psychophysiol, 18, pp.49~65 (1994)
- Ebersole JS, "Noninvasive localization of epileptogenic foci by EEG source modeling", Epilepsia, 41, pp.24~33 (2000)
- Kobayashi K, "Dipole modeling of epileptic spikes can be accurate or misleading", Epilepsia, 46, pp.397~408 (2005)
- Holmes MD, "Are generalized seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence", Epilepsia, 45, pp.1568~1579 (2004)