실소산에 대한 국내외 실험연구 고찰 : 농도와 제조 방법에 따른 약리 차이

Abstract

Objectives: This study aimed to evaluate the pharmacological effects of Silso-san (Shixiao-san, SXS), a traditional herbal medicine, with particular focus on the influence of extraction concentration and preparation method. Its therapeutic potential for blood stasis syndrome (BSS) and related gynecological or systemic diseases was assessed. Methods: A literature review was conducted on 12 experimental studies related to SXS. The analysis included pharmacological actions, active components, extraction solvents (e.g., water, vinegar, ethanol), decoction methods (co-decoction vs. mixed decoction), and comparisons with individual herbs(Pollen Typhae, Faeces Trogopterori). Pharmacodynamic indicators, such as antithrombotic, antioxidant, and anti-inflammatory effects, were reviewed. Results: SXS demonstrated various pharmacological activities, including antithrombotic, anti-inflammatory, antioxidant, hepatoprotective, cardioprotective, analgesic, and anti-proliferative effects on uterine myoma and endometriosis cells. These effects differed by concentration and preparation method. Higher concentrations generally enhanced efficacy. Traditional extraction method especially vinegar or ethanol extraction and co-decoction, significantly improved the bioavailability of key constituents like quercetin, kaempferol, and typhaneoside. Conclusions: SXS shows multifaceted pharmacological potential in BSS and gynecological disorders. Its effectiveness is strongly influenced by extraction techniques. Traditional methods such as vinegar decoction and co-decoction may enhance therapeutic value. Further clinical studies are warranted to validate safety, optimal dosing, and clinical applications.