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계지복령환의 효능에 대한 국내외 실험연구 동향 분석

The Analysis of the Experimental Research Trend of Efficacy of Gyejibokryeong-hwan

최경희|유정은|백선은|장새별
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2016.05|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제29권 제2호|pp. 99-112|DOI http://dx.doi.org/10.15204/jkobgy.2016.29.2.099

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참고문헌

키워드

research trendblood stasisGyejibokryeong-hwan
주제분류한의학

초록

Objectives: Gyejibokryeong-hwan (GBH), a traditional Korean herbal medicine, has been widely used for the treatment of the blood stasis syndrome. This study is purposed to analyze the experimental research trend of GBH in Korea for developing further research plan. Methods: A search of Korean research database-Oasis, RISS and KISS- and Pubmed was carried out for publications until 2015, for the words, 'Guizhifulingwan', ‘Gyejibokryeonghwan’, or ‘Keishibukuryogan’. Then study selection is conducted according to PRISMA guidelines, studies not related or using modified formula or administered for human are excluded, 48 studies are included in this review, finally. We analyzed studies by research method, subject, outcome measure, and result of the study. Results: There were 31 in vivo studies about the effect of GBH on platelet aggregation, anti-oxidant, blood viscosity, and hypercholesterolemia, etc. 12 in vitro studies were about the effect of GBH on the cervical carcinoma, chronic kidney disease, uterine myoma, hepatocarcinoma, atherosclerosis, cancer chemo-prevent. 9 ex vivo studies were about the effect of GBH on the platelet aggregation, chronic kidney disease, ovaulatory disorder, and rheumarthritis. Conclusions: We proposed the translational research of GBH involving scientific discoveries and developing practical applications by investigating the concept of blood stasis syndrome in terms of current physiopathological mechanism.

Abstract

Objectives: Gyejibokryeong-hwan (GBH), a traditional Korean herbal medicine, has been widely used for the treatment of the blood stasis syndrome. This study is purposed to analyze the experimental research trend of GBH in Korea for developing further research plan. Methods: A search of Korean research database-Oasis, RISS and KISS- and Pubmed was carried out for publications until 2015, for the words, 'Guizhifulingwan', ‘Gyejibokryeonghwan’, or ‘Keishibukuryogan’. Then study selection is conducted according to PRISMA guidelines, studies not related or using modified formula or administered for human are excluded, 48 studies are included in this review, finally. We analyzed studies by research method, subject, outcome measure, and result of the study. Results: There were 31 in vivo studies about the effect of GBH on platelet aggregation, anti-oxidant, blood viscosity, and hypercholesterolemia, etc. 12 in vitro studies were about the effect of GBH on the cervical carcinoma, chronic kidney disease, uterine myoma, hepatocarcinoma, atherosclerosis, cancer chemo-prevent. 9 ex vivo studies were about the effect of GBH on the platelet aggregation, chronic kidney disease, ovaulatory disorder, and rheumarthritis. Conclusions: We proposed the translational research of GBH involving scientific discoveries and developing practical applications by investigating the concept of blood stasis syndrome in terms of current physiopathological mechanism.

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