국내 한의학계의 항혈전 효과에 대한 실험 연구 고찰 - 2001년 이후 한방부인과학회지에 발표된 논문을 중심으로 -
Review of Experimental Studies on Antithrombotic in Oriental Medicine - Within Articles in The Journal of Oriental Obstetrics & Gynecology Since 2001’ -
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Purpose: The purpose of this study is to compare with the result of experimentalstudy about antithrombotic effect by reviewing recent oriental medicine journalsthat have been published since 2001‘ in Korea. Methods: Articles on antithrombotic effect that have been published from2001’ to 2013’ in oriental medicine journals registered National Research Foundationof Korea were searched. After that, 12 articles using same ‘thrombosis conditionmodel’ were selected and reviewed. Results: The results were as follows. 1. If there is no limit drug concentrations, platelet aggregation induced byadenosine diphosphate (ADP) in hyulbuchukeo-tanggamibang (HBCT) was the largestaggregation inhibitory effect and platelet aggregation induced by epinephrine inSaegeum-san (SGS), Jogan-tanggagambang (JGTG), hyulbuchukeo-tanggamibang (HBCT)had a large inhibitory effect on aggregation. 2. At the lowest concentration, Mokdan-san (MDS) of the inhibition of plateletaggregation induced by ADP and Hyunhosaik-san (HHS) of the inhibition of plateletaggregation induced by epinephrine were effective. 3. Pulmonary embolism induced by collagen and epinephrine in Neungasojeok-tang(NSJT) has the highest antithrombotic effect. 4. Pathological conditions of extravasated blood by dextran, Jogan-tanggagambang(JGTG) has the highest inhibitory effect on decrease in platelet numbers. Comparedto the rest of the experimental drug, Saegeum-san (SGS), Heanggyonghonghwa-tang(HGTHHT), Wusl-san (WSS), Mokdan-san (MDS) showed significant inhibitory effecton the prothrombin time (PT) increases. Honghwadanggui-san (HDS), Saegeum-san(SGS) showed significant inhibitory effect on increase in activated partial thromboplastintime (APTT) and Jogan-tanggagambang (JGTG), Heanggyonghonghwa-tang(HGTHHT) showed significant inhibitory effect on decrease in fibrinogen. Conclusions: This result will provide useful information for the prescriptionsof antithrombotic medicine in the field of Oriental medicine. We will have tocarry out further studies that will compare each herb used in the diseases causedby extravasated blood. Key Words: Antithrombotic,
Abstract
Purpose: The purpose of this study is to compare with the result of experimentalstudy about antithrombotic effect by reviewing recent oriental medicine journalsthat have been published since 2001‘ in Korea. Methods: Articles on antithrombotic effect that have been published from2001’ to 2013’ in oriental medicine journals registered National Research Foundationof Korea were searched. After that, 12 articles using same ‘thrombosis conditionmodel’ were selected and reviewed. Results: The results were as follows. 1. If there is no limit drug concentrations, platelet aggregation induced byadenosine diphosphate (ADP) in hyulbuchukeo-tanggamibang (HBCT) was the largestaggregation inhibitory effect and platelet aggregation induced by epinephrine inSaegeum-san (SGS), Jogan-tanggagambang (JGTG), hyulbuchukeo-tanggamibang (HBCT)had a large inhibitory effect on aggregation. 2. At the lowest concentration, Mokdan-san (MDS) of the inhibition of plateletaggregation induced by ADP and Hyunhosaik-san (HHS) of the inhibition of plateletaggregation induced by epinephrine were effective. 3. Pulmonary embolism induced by collagen and epinephrine in Neungasojeok-tang(NSJT) has the highest antithrombotic effect. 4. Pathological conditions of extravasated blood by dextran, Jogan-tanggagambang(JGTG) has the highest inhibitory effect on decrease in platelet numbers. Comparedto the rest of the experimental drug, Saegeum-san (SGS), Heanggyonghonghwa-tang(HGTHHT), Wusl-san (WSS), Mokdan-san (MDS) showed significant inhibitory effecton the prothrombin time (PT) increases. Honghwadanggui-san (HDS), Saegeum-san(SGS) showed significant inhibitory effect on increase in activated partial thromboplastintime (APTT) and Jogan-tanggagambang (JGTG), Heanggyonghonghwa-tang(HGTHHT) showed significant inhibitory effect on decrease in fibrinogen. Conclusions: This result will provide useful information for the prescriptionsof antithrombotic medicine in the field of Oriental medicine. We will have tocarry out further studies that will compare each herb used in the diseases causedby extravasated blood. Key Words: Antithrombotic,
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