저강도 초음파치료의 골절치유 효과

Abstract

Noninvasive low imtensity ultrasound has been shown to be an effective means ofaccelerating bone fracture repair in both animal and clinical studies. The effects ofultrasound stimulation on bone repair after fibular osteotomy were assessed in a rabbitfibular fracture model. Bilateral closed fibular fractures were made in skeletally maturemale White ]apanese rabbits. In this study, 24 subjects were randomly divided into 2groups: experimental group 1 (n=12), and experimental group 2 (n=12). Experimentalgroup 1 received 0.875 MHz continuous ultrasound and Experimental group 2 was treatedwith 3 MHz continuous ultrasound. The ultrasound intensity was 50 rnW/crrr and treatmenttime was 10 minutes for every session in both groups. In each rabbit, one fibula servedas a control and the other was subjected to ultrasound treatment 5 times per week for 3weeks. After 3 weeks, rabbits were sacrificed and the ratios of the area between thetrabeculae and bone marrow of the fibulae were calculated. At the end of theexperimental period, 14 of the 24 rabbits were excluded due to complications fromsurgery or inadequate fracture status for this study. There was no statisticallysignificant difference in the trabeculae area between experimental leg and control leg inexperimental group 1 and experimental group 2 (p>0.05). And there was also no statistic- statistically significant difference between experimental group 1 and experimental group 2according to ultrasound treatment frequencies, 0.875 MHz and 3 MHz (p>0.05). These datasuggest that in ]apanese white rabbits, low intensity ultrasound stimulation does notfacilitate fracture repair nor is there any difference in fracture repair results betweenultrasound frequencies, 0.875 MHZ and 3 MHz.