오령산의 고혈압 치료약물 가능성에 대한 개관
An Overview of the Applicability of Oryung-san as an Antihypertensive Agent
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Objectives: This study assessed the application of Oryung-san (Wuling-san or Gorei-san), a common diuretic in traditional medicine, as an antihypertensive agent. Methods: Experimental studies of the pharmacological properties of Oryung-san, including diuretic action and lowering effects on blood pressure, and toxicology and clinical trials were reviewed. Results: In pharmacology, various, relatively safe diuretics are used to lower blood pressure and are the oldest and most studied antihypertensive agents. Despite many new drug approvals, antihypertensive diuretics are frequently used in Korea and Japan where high levels of sodium uptake are common. Oryung-san has been demonstrated to have diuretic, antihypertensive, and nephroprotective effects. Conclusions: Oryung-san might be effective for lowering blood pressure based on the results of this literature review. Further evaluations and large-scale clinical trials of Oryung-san to treat primary hypertension are warranted.
Abstract
Objectives: This study assessed the application of Oryung-san (Wuling-san or Gorei-san), a common diuretic in traditional medicine, as an antihypertensive agent. Methods: Experimental studies of the pharmacological properties of Oryung-san, including diuretic action and lowering effects on blood pressure, and toxicology and clinical trials were reviewed. Results: In pharmacology, various, relatively safe diuretics are used to lower blood pressure and are the oldest and most studied antihypertensive agents. Despite many new drug approvals, antihypertensive diuretics are frequently used in Korea and Japan where high levels of sodium uptake are common. Oryung-san has been demonstrated to have diuretic, antihypertensive, and nephroprotective effects. Conclusions: Oryung-san might be effective for lowering blood pressure based on the results of this literature review. Further evaluations and large-scale clinical trials of Oryung-san to treat primary hypertension are warranted.
참고문헌 (49)
- Choi SW, "A multicenter cohort study of primary hypertension in Korea: study design and interim analysis of the Korean registry of target organ damage in hypertension(KorHR)", Clin Hypertens, 23(1), pp.16~ (2017)
- Whelton PK, "Epidemiology of hypertension", Lancet, 344(8915), pp.101~106 (1994)
- Guo X, "Clinical effect of qigong practice on essential hypertension: a meta-analysis of randomized controlled trials. Journal of alternative and complementary medicine", J Altern Complement Med, 14(1), pp.27~37 (2008)
- Chobanian AV, "The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report", JAMA, 289(19), pp.2560~2572 (2003)
- 신진호, "2013 Korean Society of Hypertension guidelines for the management of hypertension. Part I—epidemiology and diagnosis of hypertension", Clinical Hypertension, 21(1), pp.1~11 (2015), 대한고혈압학회[DOI]
- 김현창, "Noncommunicable Diseases: Current Status of Major Modifiable Risk Factors in Korea", 예방의학회지, 46(4), pp.165~172 (2013), 대한예방의학회
- "Pharmaceutical Industry Data Book" (2016)[URL]
- "Development of hypertension drug ‘3 in 1 combination'"[URL]
- "Medical Statistics Index" (2015)[URL]
- "Evidence -based Guideline for Hypertension in Primary Care" (2014)[URL]
- The education committee of Korean medicine college for Herbal formula science, "Herbal formula science", pp.504~506 (2003), Yeonglimsa
- Zhao YY, "Bioactivity-directed identification of diuretic compounds from Polyporus umbellatus", J Ethropharmacol, 126(1), pp.184~187 (2009)
- Yuan D, "An anti-aldosteronic diuretic component(drain dampness) in Polyporus sclerotium", Biol Pharm Bull, 27(6), pp.867~870 (2004)
- Zhu YP, "Chinese Materia Medica Chemistry: Pharmacology and Applications", pp.501~502 (1998), Harwood Academic Publishers
- Wu ZL, "Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure", J Ethropharmacol, 155(1), pp.563~571 (2014)
- Feng YL, "Diuretic and anti-diuretic activities of the ethanol and aqueous extracts of Alismatis rhizoma", J Ethropharmacol, 154(2), pp.386~390 (2014)
- Chen DQ, "Diuretic and anti-diuretic activities of fractions of Alismatis rhizoma", J Ethropharmacol, 157, pp.114~118 (2014)
- Hattori T, "Sairei-to inhibits the production of endothelin-1 by nephritic glomeruli (2): alisols, possible candidates as active compounds", Nihon Jinzo Gakkai Shi, 40(2), pp.33~41 (1998)
- Satoh K, "The effects of crude drugs using diuretic on horse kidney (Na++K+) -adenosine triphosphatase", Yakugaku Zasshi, 111(2), pp.138~145 (1991)
- Lee SI, "Studies on the diuretic action of Oryeongsan and Kami-Oryeongsan", Kor J Pharmacog, 12(1), pp.31~43 (1981)
- Ahn YM, "Oryeongsan has different effects on water and electrolyte balance by routes of administration", Master, pp.2011
- Ahn YM, "Oryeongsan (Wulingsan), a traditional Chinese herbal medicine, induces natriuresis and diuresis along with an inhibition of the renin-angiotensin-aldosterone system in rats", J Ethnopharmacol, 141, pp.780~785 (2012)
- Kim KA, "Effects of the gastric administration of Oryungsan water extract on the renal function, plasma renin activity and plasma levels of atrial natriuretic peptide in the rats", J Oriental Physiology, 11(2), pp.89~98 (1996)
- Kurita T, "Effects of Gorei-san: a traditional Japanese Kampo medicine, on aquaporin 1, 2, 3, 4 and V2R mRNA expression in rat kidney and forebrain", J Med Sci, 11(1), pp.30~38 (2011)
- Ahn YM, "Effects of Oryeongsan on Regulation of Renal Function and Hormonal Balance in Hypertensive Rats", Ph.D, pp.2016
- Han YP, "Effect of Wuling powder on rats with renal hypertension", Zhong Xi Yi Jie He Xue Bao, 1(4), pp.285~288 (2003)
- Cho DH, "Effects of Gamioryeongsan, Gamiyukmijihwangtang and vinegar on rats with acute renal failure induced by gentamicin", J Kyung Hee Univ, 7(3), pp.287~311 (1991)
- Ahn SY, "Effects of Oryeongsan and Yukmijihwangtang on rats with acute renal failure induced by gentamicin sulfate", Master, pp.1993
- Lee MG, "Effects of Paljungsan and Kamioryungsan on rats with acute renal failure induced by gentamicin sulfate", Master, pp.1997
- "Tsumura Goreisan extract granules for ethical use" (2007)[URL]
- 박화용, "오령산 열수추출물의 단회투여 급성독성 연구", 대한한의학 방제학회지, 21(1), pp.111~118 (2013), 대한한의학방제학회
- Zhang Y, "Evaluation of Toxicity of WLS", Chinese Journal of Modern Drug Application, 2(12), pp.16~18 (2008)
- 이혜윤, "오령산의 고혈압 치료 효과에 대한 체계적 고찰 : 임상 논문을 중심으로", 대한한방내과학회지, 34(3), pp.289~297 (2013), 대한한방내과학회
- Peon X, "Clinical observation on 80 cases of primary hypertension treated by Amlodipine and Danqi Wuling powder", Yunnan Journal of Traditional Chinese Medicine and Materia Medica, 32(9), pp.23~24 (2011)
- Quan Y, "Investigation of renal protective effect in early hypertensive renal injury by supplemented Wuling San combined with Liuweidihuang decoction", Capital Medicine, (8), pp.44~46 (2011)
- Fan Y, "Clinical research on treatment of Wuling power on metabolic syndrome", pp.1~50 (2012), Guangzhou University of Chinese Medicine
- 장인수, "오령산 단일 투여를 통한 일차성 고혈압 치험례", 대한한방내과학회지, 35(1), pp.106~110 (2014), 대한한방내과학회
- 전은실, "이뇨제 사용의 원칙과 실제", 대한내과학회지, 80(1), pp.8~14 (2011), 대한내과학회
- Ding XQ, "Wuling San ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice", Chin J Nat Med, 11(3), pp.214~221 (2013)
- Yang Y, "Wuling San protects kidney dysfunction by inhibiting renal TLR4", MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic, 2015, pp.169, 49~59
- Takei H, "The herbal medicines Saireito and Boiogito improve the hypertension of pre-eclamptic rats induced by Nomega-Nitro-L-arginine methyl ester", Phytomedicine, 14, pp.591~600 (2007)
- Qiu Y, "Clinical observation on effect of Wuling powder on electrolyte in patients with nephrotic syndrome", CJGMCM, 31(18), pp.2665~2668 (2016)
- Kim SY, "Influence of Goryeosin infusion solution on the change of serum electrolytes in rats", pp.1990
- Ito Y, "Pathophysiology of the Goreisan show lowering of osmolality set point", Japanese Journal of Oriental Medicine, 28, pp.91~99 (1978)
- Isohama Y, "Modulation of aquaporin water channel function by Kampo medicines", Kampo and the newest therapy, 17, pp.27~35 (2008)
- Sakamoto A, "A case of hyponatremia complicated with small cell lung cancer successfully treated with Goreisan", Kampo Med, 66(2), pp.124~130 (2015)
- The education committee of Korean medicine college for cardiology and neurology, "The cardiology and neurology in Korean medicine Vol. 2", pp.196~ (2016), Woori medical books
- "Hypertension management guidelines"[URL]
- Chae S, "Is diuretics the top priority", Cardiovascular, 5(3), pp.11~15 (2003)
