본문 바로가기
KERD
논문KCI 등재

혈부축어탕의 본태성 고혈압에 대한 치료 효과 관한 메타 분석 및 체계적 고찰

Xuefuzhuyu Decoction for Essential Hypertension: Meta-Analysis and Systemic Review

장인수|선승호|한인식
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2018.12|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제39권 제6호|pp. 1150-1167

1

조회

0

다운로드

2

인용

0

참고문헌

키워드

meta-analysisherbal medicinehypertensionsystemic reviewXuefuzhuyu decoction
주제분류한의학

초록

Objective: The purpose of this study was to investigate the effect reducing blood pressure (BP) using Xuefuzhuyu Decoction (XFZYD) in adults with essential hypertension (EH). Method: Search engine, such as PubMed, EMBASE, Cochrane library, Web of Science, J-STAGE, CiNii, CNKI, OASIS, NDSL, KISS, RISS, and DBpia, were used. The search period was from the beginning of the search engine to June 30, 2018 and there were no limits regarding languages. The selection and extraction of literatures were performed independently by two authors. Meta-analysis was done on the total effective rate (TER), Systolic BP (SBP) and Diastolic BP (DBP). Cochrane’s risk of bias (ROB) was used as the methodological quality assessment scale. Results: Twenty studies were finally selected. We observed that a combination treatment using XFZYD and an antihypertensive drug (AHD) was 5.1 times more effective in lowering BP than using AHD alone on TER. The mean differences in SBP and DBP were -10.65 mmHg (95% Confidential Interval (CI) -13.55 mmHg, -7.74 mmHg, P<0.00001), -5.92 mmHg (95% CI -7.14, -4.38, P<0.00001), respectively. Conclusion: A combination treatment using XFZYD and AHD may be more effective in reducing BP than using AHD alone. Because of the poor methodological quality of the studies conducted thus far, high-quality clinical trials will be required in the future.

Abstract

Objective: The purpose of this study was to investigate the effect reducing blood pressure (BP) using Xuefuzhuyu Decoction (XFZYD) in adults with essential hypertension (EH). Method: Search engine, such as PubMed, EMBASE, Cochrane library, Web of Science, J-STAGE, CiNii, CNKI, OASIS, NDSL, KISS, RISS, and DBpia, were used. The search period was from the beginning of the search engine to June 30, 2018 and there were no limits regarding languages. The selection and extraction of literatures were performed independently by two authors. Meta-analysis was done on the total effective rate (TER), Systolic BP (SBP) and Diastolic BP (DBP). Cochrane’s risk of bias (ROB) was used as the methodological quality assessment scale. Results: Twenty studies were finally selected. We observed that a combination treatment using XFZYD and an antihypertensive drug (AHD) was 5.1 times more effective in lowering BP than using AHD alone on TER. The mean differences in SBP and DBP were -10.65 mmHg (95% Confidential Interval (CI) -13.55 mmHg, -7.74 mmHg, P<0.00001), -5.92 mmHg (95% CI -7.14, -4.38, P<0.00001), respectively. Conclusion: A combination treatment using XFZYD and AHD may be more effective in reducing BP than using AHD alone. Because of the poor methodological quality of the studies conducted thus far, high-quality clinical trials will be required in the future.

참고문헌 (49)

  1. Dennis K, "Larry Jameson, Loscalzo J. Harrison's principles of internal medicine", pp.1611~1627 (2015), McGraw-Hill Education
  2. Garfinkle MA, "Salt and essential hypertension : pathophysiology and implications for treatment", Journal of the American Society of Hypertension, 11(6), pp.385~391 (2017)
  3. "Korean Statistical Information Service. 2016" (2016)[URL]
  4. Jarari N, "A review on prescribing patterns of antihypertensive drugs", Clinical hypertension, 22, pp.7~ (2015)
  5. 정민정, "오령산의 고혈압 치료약물 가능성에 대한 개관", 대한한방내과학회지, 38(4), pp.443~454 (2017), 대한한방내과학회
  6. "Korean statistical information service 2016"[URL]
  7. Association of Korean Medicine Professors for Cardiovascular and Neurological Medicine, "Cardiovascular and Neurological Medicine in Korean Medicine I", pp.197~198 (2016), WOORI Medical Books
  8. 양창섭, "고혈압 단계별 변증특성 분석", 동의생리병리학회지, 26(6), pp.934~939 (2012), 한의병리학회
  9. 한창현, "고혈압 환자에서 화침법(和針法)의 혈압강하 효과", Journal of Acupuncture Research, 23(6), pp.165~176 (2006), 대한침구의학회
  10. Ahn CH, "Effects of Auricular Acupuncture on the Mild Hypertension", Journal of Korean Medicine, 20(4), pp.93~97 (2000)
  11. 김정은, "폐경 후 고혈압 전단계 및 1기 고혈압에 대한 침 치료 효과: 무작위 대조 예비연구", Korean Journal of Acupuncture, 34(3), pp.116~125 (2017), 경락경혈학회[DOI]
  12. 김보성, "足三里艾灸가 고혈압 환자의 혈압 강하에 미치는 영향; 무작위배정 임상연구", 대한한의학회지, 26(3), pp.66~73 (2005), 대한한의학회
  13. 임경태, "원발성 고혈압에 대한 추나요법의 효과 : 체계적 문헌 고찰", 척추신경추나의학회지, 12(1), pp.29~42 (2017), 척추신경추나의학회
  14. 조형준, "팔단금 도인 운동이 고혈압에 미치는 영향 : 체계적 문헌 고찰", 척추신경추나의학회지, 12(1), pp.43~56 (2017), 척추신경추나의학회
  15. Chung KH, "The Effects of Samhwangsasim-tang Extracts on Ambulatory Blood Pressure in Mild Hypertensive Patients with Stroke", The Journal of Korean Chronic Diseases, 8(1), pp.41~52 (2002)
  16. 강기완, "고혈압에 대한 천마구등음의 효과 : 체계적 문헌고찰과 메타분석", 대한한방내과학회지, 39(1), pp.22~43 (2018), 대한한방내과학회
  17. 한인식, "본태성 고혈압에 대한 杞菊地黄丸의 효과에 관한 체계적 고찰 및 메타 분석", 동의생리병리학회지, 31(2), pp.118~125 (2017), 한의병리학회[DOI]
  18. 강자연, "고혈압에 대한 한약 이수 처방 효과에 대한 체계적 문헌 고찰 및 메타분석", 대한한방내과학회지, 38(6), pp.902~916 (2017), 대한한방내과학회
  19. Wang QR, "Yi lin gai cuo", pp.66~71 (2016), Bubin publisher
  20. 장새별, "혈부축어탕이 파골세포 분화 및 골흡수에 미치는 영향", 대한한방부인과학회지, 30(4), pp.1~17 (2017), 대한한방부인과학회[DOI]
  21. 김동희, "불면장애에 대한 혈부축어탕의 체계적 문헌 고찰 및 메타분석 연구", 동의신경정신과학회지, 28(4), pp.319~332 (2017), 대한한방신경정신과학회
  22. Kim HY, "Suppression of Lipid Accumulation of Hyulboochucketang in the Hepatic Tissue of Hyperlipidemic Mice by Triton WR-1339", Korean Journal of Oriental Physiology & Pathology, 14(2), pp.215~224 (1999)
  23. 조은희, "혈부축어탕이 흰쥐의 전뇌허혈에 미치는 영향", 대한한의학회지, 28(2), pp.44~53 (2007), 대한한의학회
  24. 임현정, "血府逐瘀湯加味方의 抗血栓作用에 대한 實驗的 硏究", 대한한방부인과학회지, 21(1), pp.117~133 (2008), 대한한방부인과학회
  25. Higgins JP, "The Cochrane Collaboration's tool for assessing risk of bias in randomised trials", BMJ (Clinical researched), 343, pp.d5928~ (2011)
  26. Viswanathan M, "Recommendations for assessing the risk of bias in systematic reviews of health-care interventions", Journal of clinical epidemiology, 97, pp.26~34 (2018)
  27. Hu M, "Elderly refractory hypertension randomized parallel group study Xuefuzhuyu decoction combined with western medicine", Journal of practical traditional Chinese internal medicine, 28(1), pp.123~124 (2014)
  28. Zhong LQ, "Refractory hypertension randomized controlled study Xuefuzhuyu Tang combined western medicine", Journal of practical traditional Chinese internal medicine, 29(8), pp.127~128 (2015)
  29. Wei W., "Xuefuzhuyu decoction combined norvasc treatment of essential hypertension clinical effect", Master's, pp.2011
  30. Li ZW, "Clinical effective observation on treating 50 cases of hypertension with the Xuefu Zhuyu decoction", Clinical Journal of Chinese Medicine, 7(25), pp.101~103 (2015)
  31. Huo JY, "Antihypertensive effects of Xuefu Zuyu decoction and long-acting calcium antagonists", Chinese Journal of integrative medicine on cardio-cerebrovascular disease, 2016(14), pp.8~ (2016)
  32. Duan LJ, "Elderly refractory antihypertensive effects of Xuefuzhuyu Tang combined western medicine", The Medical Journal of the Present Clinical, 2, pp.2049~2050 (2016)
  33. Song QL, "Clinical effective observation on treating 36 cases of hypertension with the Xuefu Zhuyu decoction", Journal of new chinese medicine, 42(6), pp.8~9 (2010)
  34. Li QM, "An effective analysis of treating senile hypertension with the Xuefu Zhuyu decoction", Clinical Journal of Chinese Medicine, 8(7), pp.80~81 (2016)
  35. Zhang ZH, "Clinical observation on treating 40 cases of essential hypertension with the Xuefu Zhuyu decoction combined western medicine", Henan traditional chinese medicine, 35(6), pp.1412~1413 (2015)
  36. Fu JH, "Clinical observation on treating 68 cases of essential hypertension with the Xuefu Zhuyu decoction combined Nimodipine", Jin Lin Chinese Medicine, 23(5), pp.12~13 (2003)
  37. Liu ZB, "Clinical observation on treating 64 cases of hypertension with the Xuefu Zhuyu decoction", China Practical Medicine, 5(16), pp.167~ (2010)
  38. Wang M, "Clinical observation on treating 64 cases of hypertension with the Xuefu Zhuyu decoction", China Tropical Medicine, 8(9), pp.1564~1565 (2008)
  39. Xiong LL, "The clinical research of combining both Xuefu Zhuyu tablet and anihypertensive agents for blood stasis syndrome in EH", Master’s, pp.2014
  40. Liu YW, "Clinical effective observation on treating 45 cases of hypertension with method to activate blood and resolve stasis", Clinical Journal of Guang Ming Chinese Medicine, 29(6), pp.1213~1214 (2014)
  41. Liu YM, "Clinical observation on treating cases of hypertension with the Xuefu Zhuyu decoction", Xinjiang Journal of Traditional Chinese Medicine, 32(1), pp.10~11 (2014)
  42. Shi YZ, "Observation on antihypertensive effect with the Xuefu Zhuyu decoction combined a long-term calcium antagonist", Cardiovascular disease journal of integrated traditional Chinese and western medicine, 4(18), pp.183~ (2016)
  43. Sun X, "Clinical research of treating refractory hypertension with Chinese medicine combined Western medicine", Henan Medical Research, 24(12), pp.103~ (2015)
  44. Li XF, "Clinical effective observation on treating static blood's obstruction of collateral vessel-type hypertension with the Xuefu Zhuyu decoction", Bei Fang Yao Xue, 13(5), pp.23~24 (2016)
  45. Wang Y, "Clinical observation on promoting blood circulation by removing blood stasis improve blood viscosity to influence diastolic blood pressure", Master’s, pp.2011
  46. Wang Gj, "Clinical trial of western medicine treatment combined with Xuefu Zhuyu decoction in the treatment elderly patients with refractory hypertension", Chin J Clin Pharmacol, 33(12), pp.1158~1159 (2017)
  47. Oh GS, "The effect of Heulbuchuketang on endometriosis", Journal of Korean Medicine, 18(2), pp.273~282 (1997)
  48. 김윤용, "瘀血로 인한 怔忡, 驚悸환자의 血府逐瘀湯 치험례", 동의신경정신과학회지, 20(3), pp.249~259 (2009), 대한한방신경정신과학회
  49. 양동선, "혈부축어탕으로 호전된 자궁적출술 환자 치험 3례", 대한한방부인과학회지, 24(4), pp.205~212 (2011), 대한한방부인과학회

관련 논문AI추천

본태성 고혈압에 대한 杞菊地黄丸의 효과에 관한 체계적 고찰 및 메타 분석박해모, 선승호, 신지혜, 양창섭, 장인수, 정민정, 조윤영, 한인식한의병리학회 · 동의생리병리학회지2017 · 제31권 제2호고혈압에 대한 한약 이수 처방 효과에 대한 체계적 문헌 고찰 및 메타분석강기완, 강자연, 김홍준, 장인수, 정민정대한한방내과학회 · 대한한방내과학회지2017 · 제38권 제6호고혈압에 대한 천마구등음의 효과 : 체계적 문헌고찰과 메타분석강기완, 강자연, 김홍준, 선승호, 장인수, 정민정대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제1호고혈압의 한약 치료에 대한 연구동향 분석김철, 김영은, 김진현, 김창석, 송미영, 예상준대한예방한의학회 · 대한예방한의학회지2011 · 제15권 제3호오령산의 고혈압 치료 효과에 대한 체계적 고찰 : 임상 논문을 중심으로이은, 강기완, 이승호, 이혜윤, 장인수, 한창호대한한방내과학회 · 대한한방내과학회지2013 · 제34권 제3호일개 한의원의 고혈압 한의치료 118례에 대한 고찰강자연, 김홍준, 이기향, 장인수, 정민정, 정용욱대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제4호

이 간행물의 다른 논문 (18건)

장상피화생(腸上皮化生) 치료에 대한 최신 임상 연구 동향 - CNKI 검색을 중심으로김원일, 이보람pp. 1085-1104뇌혈관질환 후 실어증의 한의학적 치료에 대한 국내 임상연구에 대한 고찰고지윤, 신현수, 손아현pp. 1105-1115갑상선 기능 항진증의 한의학적 치료에 대한 최신 연구 동향: 2000년부터 2018년까지 국내 학술논문을 중심으로 한 문헌고찰김기태, 정누리, 고흥, 신선미, 최유진, 송광찬pp. 1116-1135소화성 궤양에 대한 오패산의 치료효과 : 체계적 문헌고찰과 메타분석김승모, 최홍식, 김경순, 조나경, 이유리pp. 1136-1149홍삼의 Dexamethasone 유도 근감소증 모델 백서에 대한 효과 연구서윤정, 류재환pp. 1168-1180
원문 보기