본문 바로가기
KERD
논문KCI 등재

고혈압에 대한 한약 이수 처방 효과에 대한 체계적 문헌 고찰 및 메타분석

The Effect of Korean Herbal Medicine that Function by Inducing Diuresis for Hypertension: Systematic Review and Meta-Analysis of Randomized Controlled Trials

장인수|강기완|정민정|김홍준|강자연
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2017.12|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제38권 제6호|pp. 902-916

2

조회

0

다운로드

4

인용

0

참고문헌

키워드

Korean medicinehypertensiontraditional medicineinduce diuresis
주제분류한의학

초록

Objectives: The aim of this study was to review the clinical research on antihypertensive effects of Korean herbal medicines that function by inducing diuresis. Methods: Literature searches were performed using PubMed, Cochrane, CNKI, Wanfang, Cinii, Oasis, KISS, NDSL, RISS, DBPia, with the keywords “利水”, “利尿”, “高血壓”, “hypertension”, and “lishui.” The search range included only randomized controlled trials that verified the effects of Korean herbal medicine interventions on hypertension. The selected studies were assessed by risk of bias (RoB). Results: 26 reports were selected from a total of 532 identified. For these reports, meta-analysis was performed using Revman 5.3. From this analysis, it was observed that the combined treatment of Korean medicine and antihypertensive drugs had a significantly higher total effective rate (TER) and improvement in systolic blood pressure (SBP) and diastolic blood pressure (DBP) than did the use of a single antihypertensive drug. The risk ratio of TER for lowering blood pressure was 1.25. The mean differences of SBP, DBP were -19.63 mm Hg (95% confidential interval (CI), -22.45 mm Hg, -16.80 mm Hg, p<0.00001), and -5.39 mm Hg (95% CI, -7.36 mm Hg, -3.42 mm Hg, p<0.00001) respectively. The use of Korean medicine only did not improve blood pressure, as compared to the use of an antihypertensive drug. Most of items of RoB were unclear, and the methodological quality was low. Conclusions: The combination of antihypertensive drugs and Korean medical treatment can effectively improve SBP, DBP, and TER. This finding could be widely utilized in clinical practice in Korean medicine.

Abstract

Objectives: The aim of this study was to review the clinical research on antihypertensive effects of Korean herbal medicines that function by inducing diuresis. Methods: Literature searches were performed using PubMed, Cochrane, CNKI, Wanfang, Cinii, Oasis, KISS, NDSL, RISS, DBPia, with the keywords “利水”, “利尿”, “高血壓”, “hypertension”, and “lishui.” The search range included only randomized controlled trials that verified the effects of Korean herbal medicine interventions on hypertension. The selected studies were assessed by risk of bias (RoB). Results: 26 reports were selected from a total of 532 identified. For these reports, meta-analysis was performed using Revman 5.3. From this analysis, it was observed that the combined treatment of Korean medicine and antihypertensive drugs had a significantly higher total effective rate (TER) and improvement in systolic blood pressure (SBP) and diastolic blood pressure (DBP) than did the use of a single antihypertensive drug. The risk ratio of TER for lowering blood pressure was 1.25. The mean differences of SBP, DBP were -19.63 mm Hg (95% confidential interval (CI), -22.45 mm Hg, -16.80 mm Hg, p<0.00001), and -5.39 mm Hg (95% CI, -7.36 mm Hg, -3.42 mm Hg, p<0.00001) respectively. The use of Korean medicine only did not improve blood pressure, as compared to the use of an antihypertensive drug. Most of items of RoB were unclear, and the methodological quality was low. Conclusions: The combination of antihypertensive drugs and Korean medical treatment can effectively improve SBP, DBP, and TER. This finding could be widely utilized in clinical practice in Korean medicine.

참고문헌 (39)

  1. Ministry of health and Welfare, "2015 Health Behavior and Chronic Disease Statistics", pp.22~23 (2016), Seoul:Ministry of health and Welfare
  2. Seoul Asan Hospital internal Medicine, "2016Recent advances in internal medicine", pp.34~36 (2016), Our medical books
  3. The board of establishing guideline for diagnosis in the Korean society of hypertension, "Guideline for the diagnosis and management of hypertension in the Korean society of hypertension", pp.33~37 (2013), Ibplanning
  4. Association of Korean Medicine Professors for Cardiovascular and Neurological Medicine, "Cardiovascular and neurological medicine in Korean medicineⅡ-cardiovascular Medicine", pp.366~391 (2016), Uri medical books
  5. 이혜윤, "오령산의 고혈압 치료 효과에 대한 체계적 고찰 : 임상 논문을 중심으로", 대한한방내과학회지, 34(3), pp.289~297 (2013), 대한한방내과학회
  6. 장인수, "오령산 단일 투여를 통한 일차성 고혈압 치험례", 대한한방내과학회지, 35(1), pp.106~110 (2014), 대한한방내과학회
  7. Wu ZH, "Clinical effective observation on treating renal damage in early hypertension with the compound Chinese herbal medicine of blood-activating and urine-inducing", J of Traditional Chinese Medicine, 3, pp.109~110 (2017)
  8. Huang HM, "Effect Analysis of Dialectical prescription in treatment of hypertension in Traditional Chinese Medicine principle", China Health Standards Management, 7(4), pp.137~138 (2016)
  9. Wang SH, "Clinical observation of Chinese Medicine Lishui-Tongluo treatment on hypertension", Chinese J of Traditional Chinese Medicine and Materia Medica, 37(8), pp.49~50 (2016)
  10. Yang YM, "Clinical observation on inducing diuresis in hypertension treatment", J of Application of Integrative Medicine, 16(5), pp.41~42 (2016)
  11. Sun JH, "Clinical effective observation of Chinese Medicine Lishui-Tongluo treatment on hypertension", J of Inner Mongolian Medicine, 9, pp.52~ (2016)
  12. Liu LX, "A Clinical analysis of treating 120 cases hypertension by the Lishui therapy plus western medicine", Clinical J of Chinese Medicine, 8(13), pp.92~93 (2016)
  13. Jiang H, "Observation on curative effect of Chinese Medicine in treating hypertension", Jangxi of Tradidional Chinese Medicine, 47(400), pp.39~41 (2016)
  14. Qi BY, "Clinical observation on hypertension treated by Chinese Medicine diuresis", J of Sichuan of Traditional Chinese Medicine, 33(9), pp.85~88 (2015)
  15. Li D, "Clinical analysis of Chiniese Medicine assisted adjuvant therapy for hypertension", Asai-Pacific Traditional Medicine, 11(1), pp.104~105 (2015)
  16. Liu Q, "A Clinical analysis of treating 55 cases hypertension by the Lishui treatment", For all Health, 9(1), pp.81~82 (2015)
  17. Chen Q, "Clinical study on treatment of hypertension with Chinese Medicine diuresis", China J Ctrl Endem Dis, 29(2), pp.63~ (2014)
  18. Zhang Z, "A Clinical analysis of Chiniese Medicine assisted adjuvant therapy for hypertension", J of Inner Mogolian Medicine, 27, pp.7~8 (2014)
  19. Wang WB, "Clinical observation on hypertension by Chinese Medicine Lishui treatment", Asai-Pacific Traditional Medicine, 10(23), pp.69~ (2014)
  20. Yang N, "Clinical study of treating 68 hypertension cases by the Lishui treatment", Chinese Medicine Modern Distance Education of China, 12(12), pp.130~131 (2014)
  21. Qian G, "Analysis of Traditional Chinese Medicine diuresis in hypertensive patients", Guide of China Medicine, 11(35), pp.514~515 (2013)
  22. Zhang YF, "Randomized study of Traditional Chinese Medicine and water decoction in the treatment of hypertension", J of Practical Traditional Chinese Internal Medicine, 27(7), pp.32~33 (2013)
  23. Qian HL, "Observation on the efficacy of integrated Traditional Chinese and western medicine in the treatment of elderly patients with systolic hypertension", Henan Traditional Chinese Medicine, 30(8), pp.790~791 (2010)
  24. Zhen YH, "Clinical observation on 48 cases of hypertension treated by HuanglongSararyongtang", Fujian J of TCM, 40(1), pp.6~7 (2009)
  25. Li DR, "Clinical observation on 62 cases of Elderly Hypertension treated by Chinese medicine", J of Zhejiang Traditional Chinese Medicine, pp.201~202 (2003)
  26. Zhang WP, "Clinical Analysis of treatment of essential hypertension by herbal medicine", Primary Medicine Forum, 20(8), pp.1097~1098 (2016)
  27. Su Q, "Chinese Medicine diuresis with clinical analysis of the treatment of hypertension", J of Northern Pharmacy, 13(4), pp.12~13 (2016)
  28. Zhang XZ, "Clinical observation on inducing diuresis therapy combined with western medicine in the treatment of hypertension", Chinese Medicine Modern Distance Education of China, 14(18), pp.53~55 (2016)
  29. Wu J, "Clinical analysis of Chineses Medicine in treating hypertension", For all Health, 9(6), pp.36~37 (2015)
  30. Shen RH, "Clinical observation on treatment of hypertension by Traditional Chinese Medicine", China’s rural Health, 2, pp.16~ (2016)
  31. Peng YC, "Clinical efficacy of hypertensive patients in the treatment of traditional Chinese medicine Diuresis", For all Health, 9(4), pp.314~ (2015)
  32. Li YS, "Clinical study on treatment of hypertension with Wuling Powder", Chin J of Clinical Rational Drug Use, 9(6), pp.57~58 (2016)
  33. National Health Insurance Service, Health Insurance Review & Assessment Service, "2014 National Health Insurance Statistical Yearbook", pp.61~63 (2015), Jisung
  34. 박지은, "한방의료 이용현황 및 이용결정요인에 관한 연구 -고령화 패널을 이용하여-", 대한한의학회지, 32(1), pp.97~108 (2011), 대한한의학회
  35. 강자연, "고혈압 한의 진료 실태조사", 대한한방내과학회지, 37(6), pp.1022~1029 (2016), 대한한방내과학회
  36. 한인식, "본태성 고혈압에 대한 杞菊地黄丸의 효과에 관한 체계적 고찰 및 메타 분석", 동의생리병리학회지, 31(2), pp.118~125 (2017), 한의병리학회[DOI]
  37. Association of Korean Medicine Professors for Cardiovascular and Neurological Medicine, "Cardiovascular and neurological medicine in Korean medicineⅠ", pp.196~199 (2016), Uri medical books
  38. Utsuki S, "Role of saireito in postoperative chronic subdural hematoma recurrence prevention", J Trad Med, 29(3), pp.137~142 (2012)
  39. 정윤경, "만성 경막하 혈종(Chronic subdural hematoma, CSDH)에 대한 오령산 증례보고 2례", 대한한방내과학회지, 38(2), pp.259~263 (2017), 대한한방내과학회

관련 논문AI추천

혈부축어탕의 본태성 고혈압에 대한 치료 효과 관한 메타 분석 및 체계적 고찰선승호, 장인수, 한인식대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제6호고혈압에 대한 천마구등음의 효과 : 체계적 문헌고찰과 메타분석강기완, 강자연, 김홍준, 선승호, 장인수, 정민정대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제1호본태성 고혈압에 대한 杞菊地黄丸의 효과에 관한 체계적 고찰 및 메타 분석박해모, 선승호, 신지혜, 양창섭, 장인수, 정민정, 조윤영, 한인식한의병리학회 · 동의생리병리학회지2017 · 제31권 제2호고혈압의 한약 치료에 대한 연구동향 분석김철, 김영은, 김진현, 김창석, 송미영, 예상준대한예방한의학회 · 대한예방한의학회지2011 · 제15권 제3호일개 한의원의 고혈압 한의치료 118례에 대한 고찰강자연, 김홍준, 이기향, 장인수, 정민정, 정용욱대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제4호오령산의 고혈압 치료 효과에 대한 체계적 고찰 : 임상 논문을 중심으로이은, 강기완, 이승호, 이혜윤, 장인수, 한창호대한한방내과학회 · 대한한방내과학회지2013 · 제34권 제3호

이 간행물의 다른 논문 (19건)

AOM/DSS 유발 대장암에 대한 楡根皮와 白花蛇舌草 단일 및 배합 추출물의 항암 및 항염 효과이선아, 백동기, 문구pp. 863-876Protective Effect of Lonicerae Flos Aqueous Extracts on a Pressure Overload-induced Heart Failure Model백경민, 장우석, 신재욱pp. 877-890택사와 alisol B acetate의 병용 투여가 천식 동물 모델에 미치는 영향한창우, 허준이, 박미준, 권민정pp. 891-901‘항암화학요법을 받은 폐암 환자의 예비 통합의학 임상경로’ 개발 및 타당도 평가최준용, 김윤성, 심소현, 홍미나, 윤성훈pp. 917-929홍의약침 단일요법이 여성 하부요로증상에 미치는 임상적 효과에 대한 후향적 설문조사 연구김원일, 최승배, 김용수, 황윤경pp. 930-943
원문 보기