오령산 효능에 관한 기초 실험 연구 문헌 분석
Analysis of biological experiment on Oryeong-san (Wuling-san)
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초록
Objectives : To establish objective and scientific evidence of Korean medicine (KM), the papers on Oryeong-san (Wuling-san) frequently used in medical institutions of Korean Medicine were analyzed. Methods : The papers were classified by the registration of domestic or international journals, the year of publication, experimental fields and the kinds of studies on biological activities. The therapeutic mechanism was investigated in accordance with therapeutic effect of Oryeong-san (Wuling-san). Results : Out of 57 articles selected, 16 were published in domestic journals, 17 were in Chinese journals and 24 were in Japanese journals. Most papers reported as biological activities were on improvement of renal function. Oryeong-san (Wuling-san) increased urine factor such as urine excretion and electrolyte balance while decreasing proteinuria, serum factors including creatinine, cholesterol and triglyceride. In addition, injured renal tissue was recovered normally and gene expression controlling urine excretion was down-regulated. Conclusions : Improvement of renal function could be interpreted as objective and scientific evidence for Oryeong-san (Wuling-san).
Abstract
Objectives : To establish objective and scientific evidence of Korean medicine (KM), the papers on Oryeong-san (Wuling-san) frequently used in medical institutions of Korean Medicine were analyzed. Methods : The papers were classified by the registration of domestic or international journals, the year of publication, experimental fields and the kinds of studies on biological activities. The therapeutic mechanism was investigated in accordance with therapeutic effect of Oryeong-san (Wuling-san). Results : Out of 57 articles selected, 16 were published in domestic journals, 17 were in Chinese journals and 24 were in Japanese journals. Most papers reported as biological activities were on improvement of renal function. Oryeong-san (Wuling-san) increased urine factor such as urine excretion and electrolyte balance while decreasing proteinuria, serum factors including creatinine, cholesterol and triglyceride. In addition, injured renal tissue was recovered normally and gene expression controlling urine excretion was down-regulated. Conclusions : Improvement of renal function could be interpreted as objective and scientific evidence for Oryeong-san (Wuling-san).
참고문헌 (78)
- 방제학, "방제학", pp.504~506 (2003), 영림사
- 박요한, "한방의료기관 한약제제 구비 현황 조사 연구", 대한한의학 방제학회지, 18(1), pp.43~56 (2010), 대한한의학방제학회
- 李尙仁, "오령산 및 가미오령산이 가토이뇨작용에 미치는 영향", 박사, 한의학과, pp.1980
- 田中 重雄, "五苓散料の薬理活性に基づく処方解析", 薬学雑誌, 104(6), pp.601~606 (1984)
- 朴炫局, "家免의 利尿와 尿成分 變化에 미치는 五苓散 및 四物湯의 影響", 동서의학, 10(2), pp.18~30 (1985)
- 金信錫, "오령산 煎湯液이 白鼠의 血淸 電解質 變化에 미치는 影響", 석사, 한의학, pp.1990
- 安世永, "오령산 및 六味地黃湯이 Gentamicin Sulfate로 誘發된 白鼠의 急性腎不全에 미치는 영향", 박사, 한의학, pp.1993
- 임령해, "오령산, 六味地黃湯, 補中益氣湯, 人蔘敗毒散이 Gentamicin sulfate로 손상시킨 백서의 腎組織病變에 미치는 영향", 석사, 내과학, pp.1995
- 中西 由香, "利水剤としての五苓散の作用第 3 報", The general meeting of Medical and Pharmaceutical Society for Wakan-yaku, 12, pp.41~ (1995)
- 周联, "五苓散及其组分对正常小鼠血浆心钠素含量的影响", 中国中西医结合杂志, 15(1), pp.36~37 (1995)
- 金京娥, "五苓散煎湯液의 胃內 直接投與가 白鼠의 腎臟機能과 血漿 Renin 활성도 및 Atrial Natriuretic Peptide 濃度에 미치는 影響", 동의생리학회지, 11(2), pp.89~98 (1996)
- 金洸洙, "補中益氣湯, 蔘苓白朮散이 Mesanial Cell 증식과 Fibronectin 발현에 미치는 影響", 석사, 한의학과, pp.2000
- 大西 憲明, "モデルマウスを用いた漢方方剤の利水作用の検証", 和漢医薬学雑誌, 17, pp.131~136 (2000)
- 赤瀬朋秀, "単離灌流腎を用いたラット腎に対する五苓散の薬理効果に関する実験的検討", 和漢医薬学雑誌, 17, pp.215~220 (2000)
- 織田 真智子, "五苓散及び構成生薬 1 抜き処方のピューロマイシンアミノヌクレオシド(PA)腎障害に及ぼす作用", 和漢医薬学雑誌, 19, pp.60~ (2002)
- 韩宇萍, "五苓散对阿霉素型肾病综合征大鼠治疗作用的实验研究", 中药新药与临床药理, 14(4), pp.223~227 (2003)
- 何�岚, "五苓散含药血清对大鼠系膜细胞增殖性及细胞外基质的影响", 中药材, 29(8), pp.819~820 (2006)
- 何�岚, "五苓散保护阿霉素肾病大鼠肾小球滤过屏障的实验研究", 中药材, 29(3), pp.272~274 (2006)
- 何�岚, "五苓散减轻阿霉素肾病大鼠蛋白尿的实验研究", 中成药, 28(10), pp.1532~1534 (2006)
- 何�岚, "五苓散对阿霉素肾病大鼠肾脏血流动力学的影响", 中国中药杂志, 31(16), pp.1358~1360 (2006)
- 何岚, "五苓散对阿霉素肾病大鼠肾组织内皮素A型受体表达的影响", 中成药, 29(7), pp.963~966 (2007)
- He L, "Amelioration of anti-cancer agent adriamycin- induced nephrotic syndrome in rats by Wulingsan (Gorei-San), a blended traditional Chinese herbal medicine", Food Chem Toxicol, 46, pp.1452~1460 (2008)
- 안유미, "Oryeongsan has different effects on water and electrolyte balance by routes of administration", 석사, pp.2010
- Kurita T, "Effects of Gorei-san: A Traditional Japanese Kampo Medicine, on Aquaporin 1, 2, 3, 4 and V2R mRNA Expression in Rat Kidney and Forebrain", J Med Sci, 11(1), pp.30~38 (2011)
- 松原 利行, "脳卒中易発性高血圧ラット(SHRSP) における五苓散の脳卒中予防効果", The general meeting of Medical and Pharmaceutical Society for Wakan-yaku, 10, pp.46~ (1993)
- 张仲一, "五苓散对大白鼠实验性急性肾型高血压影响的实验观察", 天津中医, 11(4), pp.29~30 (1994)
- 織田 真智子, "Deoxycorticosterone acetate(DOCA)-食塩高血圧ラットに対する五苓散, 柴苓湯の作用", The general meeting of Medical and Pharmaceutical Society for Wakan-yaku, 16, pp.102~ (1999)
- 前田 佳奈, "脳卒中易発症性高血圧自然発症ラット(SHRSP) に対する五苓散, 柴苓湯の作用", The general meeting of Medical and Pharmaceutical Society for Wakan-yaku, 16, pp.101~ (1999)
- 前田 佳奈, "脳卒中易発症性高血圧自然発症ラット(SHRSP) に対する五苓散⋅柴苓湯の生体内水の動態に及ぼす作用", 和漢医薬学雑誌, 17, pp.81~ (2000)
- 織田 真智子, "五苓散変方および柴苓湯の脳卒中易発症性高血圧自然発症ラット(SHRSP) における水代謝調節作用", 和漢医薬学雑誌, 17, pp.157~164 (2000)
- 韩宇萍, "五苓散对肾性高血压大鼠降压作用的实验研究", 中西医结合学报, 1(4), pp.285~288 (2003)
- 前田 佳奈, "Deoxycorticosterone acetate(DOCA)誘発高血圧ラットに対する漢方薬 : 五苓散変方および柴苓湯の作用", 和漢医薬学雑誌, 20(2), pp.74~81 (2003)
- 大島 佳奈, "生体内水の動態に及ぼす五苓散の作用(一般演題抄録, 第55回近畿大学医学会学術講演会)", 近畿大医誌, 29(1), pp.22~ (2004)
- 李春娟, "仲景五苓散法对实验性代谢综合征大鼠高血压的影响", 吉林中医药, 27(5), pp.56~ (2007)
- 李春娟, "五苓散治疗代谢性高血压的实验研究", 吉林中医药, 28(2), pp.150~151 (2008)
- Kiga C, "Effects of traditional Japanese(Kampo) medicines(orengedokuto, goreisan and shichimotsukokato) on the onset of stroke and expression patterns of plasma proteins in spontaneously hypertensive stroke-prone rats", 和漢医薬学雑誌, 25(5), pp.125~132 (2008)
- 秋山 一誠, "CCl4 肝障害に対する利水剤(五苓散)の作用第 1 報", The general meeting of Medical and Pharmaceutical Society for Wakan-yaku, 10, pp.71~ (1993)
- 織田 真智子, "CCl4 肝障害に対する利水剤(五苓散)の作用第 2 報", The general meeting of Medical and Pharmaceutical Society for Wakan-yaku, 10, pp.72~ (1993)
- 織田 真智子, "CCl4 肝障害に対する利水剤(五苓散)の作用", The general meeting of Medical and Pharmaceutical Society for Wakan-yaku, 12, pp.42~ (1995)
- 신흥묵, "五苓散의 전 처치가 CCl4 投與로 인한 흰쥐의 肝의 SOD 活性 및 過酸化脂質 含量에 미치는 影響", 동의생리학회지, 11(1), pp.171~180 (1996)
- 권오성, "五苓散이 CCl4 投與로 인한 흰쥐의 損傷肝에 미치는 影響", 한의학연구소 논문집, 5(1), pp.131~147 (1996)
- 이준희, "五苓散이 Galactosamine 誘導 肝毒性 흰쥐의 Antioxidant Enzyme 活性과 Lipid peroxidation에 미치는 影響", 대한한방내과학회지, 18(1), pp.218~230 (1997)
- 織田真智子, "CCl4肝障害に対する五苓散の作用", 和漢医薬学雑誌, 15(1), pp.78~82 (1998)
- 金貞娟, "오령산과 오령산가창술이 비만 백서의 체중에 미치는 영향", 석사, 한의학, pp.1994
- 白炅龍, "오령산이 Dexamethasone등으로 유도된 adipocyte에 미치는 영향", 석사, 한의학, pp.1995
- 李相奉, "五笭散이 肥滿誘道 흰쥐의 체중 및 血淸脂質에 미치는 영향", 석사, 한의학, pp.1997
- 林瑩鎬, "五岺散의 肥滿誘導 白鼠의 肝과 副辜丸周圍의 脂肪組織, 血淸脂質 및 尿中 Hormone의 變化에 關한 硏究", 박사, 한의학, pp.1998
- 上川床総一郎, "ウシ毛様体筋に対する漢方製剤の作用", 日本眼科学会雑誌, 98(11), pp.1061~1066 (1994)
- 植田 孝子, "角膜新生血管モデルにおける柴苓湯, 五苓散または小柴胡湯の効果", 和漢医薬学会大会要旨集, 14, pp.129~ (1997)
- 山田 利津子, "網膜浮腫改善剤五苓散投与後の家兎眼窩内動脈の血流動態", 和漢医薬学雑誌, 19, pp.72~ (2002)
- 森元 康夫, "糖尿病動物KKAyマウスの血糖値, 飲水量及び尿量に対する白虎加人参湯, 防風通聖散及び五苓散の作用", 薬学雑誌, 122(2), pp.163~168 (2002)
- 신은정, "오령산의 피오글리타존 부작용 경감 효과", 약 학 회 지, 51(4), pp.307~312 (2007), 대한약학회
- Liua IM, "The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San(Hoelen Five Herb Formula), a traditional Chinese prescription", J Ethnopharmacol, 124, pp.211~218 (2009)
- 刘洋, "五苓散对腹泻模型小鼠结肠AQP-4mRNA表达的影响", 中国中医基础医学杂志, 11(3), pp.197~198 (2005)
- 岡村 信幸, "塩類下剤誘発下痢モデルマウスに対する五苓散の効果", 日本東洋醫學雜誌, 60(5), pp.493~501 (2009)
- 高立云, "中药方剂五苓散对SLT-2e影响大鼠肠黏膜微血管内皮细胞分泌NO的观察", 中獸醫醫藥雜志, 27(6), pp.17~19 (2008)
- 李岩, "五苓散对小鼠胃排空及小肠推进功能的影响", 中华消化杂志, 17(1), pp.9~ (1997)
- 伊丹 孝文, "細菌内毒素による発熱ウサギを用いた漢方方剤の解熱作用の検討", 藥學雜誌, 112(2), pp.129~134 (1992)
- 张银卿, "五苓散的毒性评价", 中国现代药物应用, 2(12), pp.16~18 (2008)
- Pitts RF, "Studies on diuretics. II. The relationship between glomerular filtration rate, proximal tubular absorption of sodium and diuretic efficacy of mercurials", J Clin Invest, 29(3), pp.372~379 (1950)
- Matsukawa T, "Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial natriuretic peptide in humans", Am J Physiol Regul Integr Comp Physiol, 300(3), pp.624~629 (2011)
- Boldt J, "Physiology and Pathophysiology of the Natriuretic Peptide System", Yearbook of Intensive Care and Emergency Medicine, 3, pp.101~109 (2006)
- Tamma G, "Cell culture models and animal models for studying the patho-physiological role of renal aquaporins", Cell Mol Life Sci (2011)[DOI]
- Alarifia S, "Blood chemical changes and renal histological alterations induced by gentamicin in rats", Saudi Journal of Biological Sciences, 19(1), pp.103~110 (2012)
- Dunér F, "Permeability, Ultrastructural Changes, and Distribution of Novel Proteins in the Glomerular Barrier in Early Puromycin Aminonucleoside Nephrosis", Nephron Exp Nephrol, 116, pp.42~52 (2010)
- 保莉, "单次尾静脉注射嘌呤霉素氨基核苷制作大鼠肾病模型的研究和评价", 宁夏医学杂志, 8, pp.689~691 (2011)
- Morita Y, "Decrease in glomerular filtration rate by plasma low-density lipoprotein cholesterol in subjects with normal kidney function assessed by urinalysis and plasma creatinine", Atherosclerosis, 210(2), pp.602~606 (2010)
- Baigent C, "The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease(Study of Heart and Renal Protection): a randomised placebo-controlled trial", Lancet, 377(9784), pp.2181~2192 (2011)
- Goruppi S, "Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy", EMBO J, 21(20), pp.5427~5436 (2002)
- Gomez-Garre D, "Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth", Hypertension, 27, pp.885~892 (1996)
- Menè P, "Physiology and pathophysiology of the mesangial cell", Nefrologia, 14, pp.8~13 (1996)
- 赵洪雯, "大鼠阿霉素肾病超微结构转变过程实验研究", 重庆医学, 37(8), pp.798~799 (2008)
- Jeansson M, "Adriamycin Alters Glomerular Endothelium to Induce Proteinuria", J Am Soc Nephrol, 20, pp.114~122 (2009)
- 고철우, "신사구체 기저막의 Heparan Sulfate Proteoglycan(HSPG)", 소아과, 39(12), pp.1643~1652 (1996)
- Welsh GI, "Nephrin - signature molecule of the glomerular podocyte?", J Pathol, 220, pp.328~337 (2010)
- Neil S. Sheerin, "A Novel Role for Nephrin in the Maintenance of Glomerular Structure", J Am Soc Nephrol, 20, pp.1661~1663 (2009)
- Gao X, "Angiopoietin-like protein 3 regulates the motility and permeability of podocytes by altering nephrin expression in vitro", Biochem Biophys Res Commun, 399, pp.31~36 (2010)
- Ren Z, "Angiotensin II induces nephrin dephosphorylation and podocyte injury: Role of caveolin-1", Cell Signal, 24(2), pp.443~450 (2012)
