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Gut microbiome-produced metabolites in pigs: a review on their biological functions and the influence of probiotics

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초록

The gastrointestinal tract is a complex ecosystem that contains a large number of microorganisms with different metabolic capacities. Modulation of the gut microbiome can improve the growth and promote health in pigs. Crosstalk between the host, diet, and the gut microbiome can influence the health of the host, potentially through the production of several metabolites with various functions. Short-chain and branched-chain fatty acids, secondary bile acids, polyamines, indoles, and phenolic compounds are metabolites produced by the gut microbiome. The gut microbiome can also produce neurotransmitters (such as γ-aminobutyric acid, catecholamines, and serotonin), their precursors, and vitamins. Several studies in pigs have demonstrated the importance of the gut microbiome and its metabolites in improving growth performance and feed efficiency, alleviating stress, and providing protection from pathogens. The use of probiotics is one of the strategies employed to target the gut microbiome of pigs. Promising results have been published on the use of probiotics in optimizing pig production. This review focuses on the role of gut microbiome-derived metabolites in the performance of pigs and the effects of probiotics on altering the levels of these metabolites.

Abstract

The gastrointestinal tract is a complex ecosystem that contains a large number of microorganisms with different metabolic capacities. Modulation of the gut microbiome can improve the growth and promote health in pigs. Crosstalk between the host, diet, and the gut microbiome can influence the health of the host, potentially through the production of several metabolites with various functions. Short-chain and branched-chain fatty acids, secondary bile acids, polyamines, indoles, and phenolic compounds are metabolites produced by the gut microbiome. The gut microbiome can also produce neurotransmitters (such as γ-aminobutyric acid, catecholamines, and serotonin), their precursors, and vitamins. Several studies in pigs have demonstrated the importance of the gut microbiome and its metabolites in improving growth performance and feed efficiency, alleviating stress, and providing protection from pathogens. The use of probiotics is one of the strategies employed to target the gut microbiome of pigs. Promising results have been published on the use of probiotics in optimizing pig production. This review focuses on the role of gut microbiome-derived metabolites in the performance of pigs and the effects of probiotics on altering the levels of these metabolites.

참고문헌 (198)

  1. Woonwong Y, "The future of the pig industry after the introduction of African swine fever into Asia", Anim Front, 10, pp.30~37 (2020)[DOI]
  2. The EU pig meat sector, "Augère-Granier ML", European Parliamentary Research Service, ~, pp.Report No.: PE 652.044 (2020)
  3. Maltecca C, "The interaction between microbiome and pig efficiency : a review", J Anim Breed Genet, 137, pp.4~13 (2020)[DOI]
  4. Bergamaschi M, "Gut microbiome composition differences among breeds impact feed efficiency in swine", Microbiome, 8, pp.110~ (2020)[DOI]
  5. Oh JK, "Association between the body weight of growing pigs and the functional capacity of their gut microbiota", Anim Sci J, 91, pp.e13418~ (2020)[DOI]
  6. Gardiner GE, "Impact of intestinal microbiota on growth and feed efficiency in pigs : a review", Microorganisms, 8, pp.1886~ (2020)[DOI]
  7. Wang X, "Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria", Microbiome, 7, pp.109~ (2019)[DOI]
  8. Jiang H, "Identification of the relationship between the gut microbiome and feed efficiency in a commercial pig cohort", J Anim Sci, 99, pp.skab045~ (2021)[DOI]
  9. Hillman ET, "Microbial ecology along the gastrointestinal tract", Microbes Environ, 32, pp.300~313 (2017)[DOI]
  10. Pluske JR, "Gastrointestinal tract(gut)health in the young pig", Anim Nutr, 4, pp.187~196 (2018)[DOI]
  11. Sun X, "Microbiome modulates intestinal homeostasis against inflammatory diseases", Vet Immunol Immunopathol, 205, pp.97~105 (2018)[DOI]
  12. Zimmermann JA, "Effects of probiotics in swines growth performance : a meta-analysis of randomised controlled trials", Anim Feed Sci Technol, 219, pp.280~293 (2016)[DOI]
  13. Barba-Vidal E, "Practical aspects of the use of probiotics in pig production : a review", Livest Sci, 223, pp.84~96 (2019)[DOI]
  14. Kim HB, "The pig gut microbial diversity : understanding the pig gut microbial ecology through the next generation high throughput sequencing", Vet Microbiol, 177, pp.242~251 (2015)[DOI]
  15. Ding S, "The impact of probiotics on gut health via alternation of immune status of monogastric animals", Anim Nutr, 7, pp.24~30 (2021)[DOI]
  16. Valeriano VDV, "Probiotic roles of Lactobacillus sp. in swine : insights from gut microbiota", J Appl Microbiol, 122, pp.554~567 (2017)[DOI]
  17. Chen Y, "Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders", Nutrients, 13, pp.2099~ (2021)[DOI]
  18. Chen C, "Expanded catalog of microbial genes and metagenome-assembled genomes from the pig gut microbiome", Nat Commun, 12, pp.1106~ (2021)[DOI]
  19. Baquero F, "The microbiome as a human organ", Clin Microbiol Infect, 18, pp.2~4 (2012)[DOI]
  20. Simon JC, "Host-microbiota interactions : from holobiont theory to analysis", Microbiome, 7, pp.5~ (2019)[DOI]
  21. Riccio P, "The human gut microbiota is neither an organ nor a commensal", FEBS Lett, 594, pp.3262~3271 (2020)[DOI]
  22. Brody H, "The gut microbiome", Nature, 577, pp.S5~ (2020)[DOI]
  23. Shreiner AB, "The gut microbiome in health and in disease", Curr Opin Gastroenterol, 31, pp.69~75 (2015)[DOI]
  24. Chalvon-Demersay T, "Functional amino acids in pigs and chickens : implication for gut health", Front Vet Sci, 8, pp.663727~ (2021)[DOI]
  25. Jenkins TA, "Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis", Nutrients, 8, pp.56~ (2016)[DOI]
  26. Mazzoli R, "The neuro-endocrinological role of microbial glutamate and GABA signaling", Front Microbiol, 7, pp.1934~ (2016)[DOI]
  27. Zhang L, "Spatial heterogeneity and co-occurrence of mucosal and luminal microbiome across swine intestinal tract", Front Microbiol, 9, pp.48~ (2018)[DOI]
  28. Ridlon JM, "Bile acids and the gut microbiome", Curr Opin Gastroenterol, 30, pp.332~338 (2014)[DOI]
  29. Scott KP, "Dietary fibre and the gut microbiota", Nutr Bull, 33, pp.201~211 (2008)[DOI]
  30. O’Grady J, "Review article : dietary fibre in the era of microbiome science", Aliment Pharmacol Ther, 49, pp.506~515 (2019)[DOI]
  31. Kasubuchi M, "Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation", Nutrients, 7, pp.2839~2849 (2015)[DOI]
  32. Baxter NT, "Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers", mBio, 10, pp.e02566~18 (2019)[DOI]
  33. Holscher HD, "Dietary fiber and prebiotics and the gastrointestinal microbiota", Gut Microbes, 8, pp.172~184 (2017)[DOI]
  34. Luise D, "Meta-analysis to evaluate the impact of the reduction of dietary crude protein on the gut health of post-weaning pigs", Ital J Anim Sci, 20, pp.1386~1397 (2021)[DOI]
  35. Tamanai-Shacoori Z, "Roseburia spp.: a marker of health?", Future Microbiol, 12, pp.157~170 (2017)[DOI]
  36. Liu X, "Blautia—a new functional genus with potential probiotic properties?", Gut Microbes, 13, pp.1875796~ (2021)[DOI]
  37. Biddle A, "Untangling the genetic basis of fibrolytic specialization by lachnospiraceae and ruminococcaceae in diverse gut communities", Diversity, 5, pp.627~640 (2013)[DOI]
  38. Louis P, "Formation of propionate and butyrate by the human colonic microbiota", Environ Microbiol, 19, pp.29~41 (2017)[DOI]
  39. Zhu Z, "Dynamic regulation of gut Clostridium-derived short-chain fatty acids", Trends Biotechnol, 40, pp.266~270 (2022)[DOI]
  40. Parada Venegas D, "Short chain fatty acids(SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases", Front Immunol, 10, pp.277~ (2019)[DOI]
  41. den Besten G, "Shortchain fatty acids protect against high-fat diet–induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation", Diabetes, 64, pp.2398~2408 (2015)[DOI]
  42. Macfarlane S, "Regulation of short-chain fatty acid production", Proc Nutr Soc, 62, pp.67~72 (2003)[DOI]
  43. Liu WC, "Application of complex probiotics in swine nutrition – a review", Ann Anim Sci, 18, pp.335~350 (2018)[DOI]
  44. Barcenilla A, "Phylogenetic relationships of butyrate-producing bacteria from the human gut", Appl Environ Microbiol, 66, pp.1654~1661 (2000)[DOI]
  45. Mishiro T, "Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8", Lab Invest, 93, pp.834~843 (2013)[DOI]
  46. Liu Y, "Fatty acids, inflammation and intestinal health in pigs", J Anim Sci Biotechnol, 6, pp.41~ (2015)[DOI]
  47. Zhong X, "Microbial-driven butyrate regulates jejunal homeostasis in piglets during the weaning stage", Front Microbiol, 9, pp.3335~ (2019)[DOI]
  48. Han Y, "Butyrate mitigates weanling piglets from lipopolysaccharide-induced colitis by regulating microbiota and energy metabolism of the gut–liver axis", Front Microbiol, 11, pp.588666~ (2020)[DOI]
  49. Grilli E, "Butyrate modulates inflammatory cytokines and tight junctions components along the gut of weaned pigs", J Anim Sci, 94, pp.433~436 (2016)[DOI]
  50. Zhang Y, "Cecal infusion of sodium propionate promotes intestinal development and jejunal barrier function in growing pigs", Animals, 9, pp.284~ (2019)[DOI]
  51. Smith PM, "The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis", Science, 341, pp.569~573 (2013)[DOI]
  52. Xiaoming Deng, "Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination", Experimental and Molecular Medicine, 51, pp.1~13 (2019), 생화학분자생물학회[DOI]
  53. Reyer H, "Host-microbiota interactions in ileum and caecum of pigs divergent in feed efficiency contribute to nutrient utilization", Microorganisms, 8, pp.563~ (2020)[DOI]
  54. McCormack UM, "Exploring a possible link between the intestinal microbiota and feed efficiency in pigs", Appl Environ Microbiol, 83, pp.e00380~17 (2017)[DOI]
  55. Jiao A, "Infusion of short chain fatty acids in the ileum improves the carcass traits, meat quality and lipid metabolism of growing pigs", Anim Nutr, 7, pp.94~100 (2021)[DOI]
  56. Gilbert MS, "Protein fermentation in the gut;implications for intestinal dysfunction in humans, pigs, and poultry", Am J Physiol Gastrointest Liver Physiol, 315, pp.G159~70 (2018)[DOI]
  57. Ran-Ressler RR, "Branched-chain fatty acids in the neonatal gut and estimated dietary intake in infancy and adulthood", The Importance of Immunonutrition: 77th Nestlé Nutrition Institute Workshop, pp.133~143 (2013)
  58. Ran-Ressler RR, "Branched chain fatty acids reduce the incidence of necrotizing enterocolitis and alter gastrointestinal microbial ecology in a neonatal rat model", PLOS ONE, 6, pp.e29032~ (2011)[DOI]
  59. Boudry G, "Dietary protein excess during neonatal life alters colonic microbiota and mucosal response to inflammatory mediators later in life in female pigs", J Nutr, 143, pp.1225~1232 (2013)[DOI]
  60. Pieper R, "Health relevance of intestinal protein fermentation in young pigs", Anim Health Res Rev, 17, pp.137~147 (2016)[DOI]
  61. Rios-Covian D, "An overview on fecal branched short-chain fatty acids along human life and as related with body mass index : associated dietary and anthropometric factors", Front Microbiol, 11, pp.973~ (2020)[DOI]
  62. Rist VTS, "Impact of dietary protein on microbiota composition and activity in the gastrointestinal tract of piglets in relation to gut health : a review", Animal, 7, pp.1067~1078 (2013)[DOI]
  63. Belenguer A, "Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut", Appl Environ Microbiol, 72, pp.3593~3599 (2006)[DOI]
  64. Brestenský M, "The content of short chain fatty acids in the jejunal digesta, caecal digesta and faeces of growing pigs", Livest Sci, 205, pp.106~110 (2017)[DOI]
  65. Fiorucci S, "Bile-acid-activated receptors : targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders", Trends Pharmacol Sci, 30, pp.570~580 (2009)[DOI]
  66. Ding L, "Bile acid nuclear receptor FXR and digestive system diseases", Acta Pharma Sin B, 5, pp.135~144 (2015)[DOI]
  67. Rizzo G, "Role of FXR in regulating bile acid homeostasis and relevance for human diseases", Curr Drug Targets Immune Endocr Metab Disord, 5, pp.289~303 (2005)[DOI]
  68. Lin S, "Undernutrition shapes the gut microbiota and bile acid profile in association with altered gut-liver FXR signaling in weaning pigs", J Agric Food Chem, 67, pp.3691~3701 (2019)[DOI]
  69. Lin S, "Dietary supplementation with Lactobacillus plantarum modified gut microbiota, bile acid profile and glucose homoeostasis in weaning piglets", Br J Nutr, 124, pp.797~808 (2020)[DOI]
  70. Song M, "Hyodeoxycholic acid(HDCA)suppresses intestinal epithelial cell proliferation through FXR-PI3K", AKT pathway, accompanied by alteration of bile acids metabolism profiles induced by gut bacteria, 2020, pp.34, 7103~7117
  71. Grüner N, "Bile acids and microbiota : multifaceted and versatile regulators of the liver–gut axis", Int J Mol Sci, 22, pp.1397~ (2021)[DOI]
  72. Wylensek D, "A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity", Nat Commun, 11, pp.6389~ (2020)[DOI]
  73. Ní Dhonnabháín R, "Aberrant gut-to-brain signaling in irritable bowel syndrome-the role of bile acids", Front Endocrinol, 12, pp.745190~ (2021)[DOI]
  74. Zhan K, "Gut microbiota-bile acid crosstalk in diarrhea-irritable bowel syndrome", BioMed Res Int, 2020, pp.3828249~ (2020)[DOI]
  75. Matsumoto M, "The relationship between microbiota and polyamine concentration in the human intestine : a pilot study", Microbiol Immunol, 51, pp.25~35 (2013)[DOI]
  76. Tofalo R, "Polyamines and gut microbiota", Front Nutr, 6, pp.16~ (2019)[DOI]
  77. Ramos-Molina B, "Dietary and gut microbiota polyamines in obesity-and age-related diseases", Front Nutr, 6, pp.24~ (2019)[DOI]
  78. Sabater-Molina M, "Effects of fructooligosaccharides on cecum polyamine concentration and gut maturation in earlyweaned piglets", J Clin Biochem Nutr, 48, pp.230~236 (2011)[DOI]
  79. Sabater-Molina M, "Effects of dietary polyamines at physiologic doses in early-weaned piglets", Nutrition, 25, pp.940~946 (2009)[DOI]
  80. Tan C, "A review of the amino acid metabolism in placental function response to fetal loss and low birth weight in pigs", J Anim Sci Biotechnol, 13, pp.28~ (2022)[DOI]
  81. Wu G, "Polyamine synthesis from proline in the developing porcine placenta", Biol Reprod, 72, pp.842~850 (2005)[DOI]
  82. Fang T, "Spermine : new insights into the intestinal development and serum antioxidant status of suckling piglets", RSC Adv, 6, pp.31323~31335 (2016)[DOI]
  83. van Wettere WHEJ, "Effect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristics", Animal, 10, pp.1655~1659 (2016)[DOI]
  84. Gierse LC, "A multi-omics protocol for swine feces to elucidate longitudinal dynamics in microbiome structure and function", Microorganisms, 8, pp.1887~ (2020)[DOI]
  85. Ewtushik AL, "Intestinal development of early-weaned piglets receiving diets supplemented with selected amino acids or polyamines", Can J Anim Sci, 80, pp.653~662 (2000)[DOI]
  86. Ma Y, "Role of dietary amino acids and microbial metabolites in the regulation of pig intestinal health", Anim Nutr, 9, pp.1~6 (2022)[DOI]
  87. Davila AM, "Intestinal luminal nitrogen metabolism : role of the gut microbiota and consequences for the host", Pharmacol Res, 68, pp.95~107 (2013)[DOI]
  88. Zhao J, "Dietary protein and gut microbiota composition and function", Curr Protein Pept Sci, 20, pp.145~154 (2019)[DOI]
  89. Dodd D, "A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites", Nature, 551, pp.648~652 (2017)[DOI]
  90. Wlodarska M, "Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation", Cell Host Microbe, 22, pp.25~37 (2017)[DOI]
  91. Shimada Y, "Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon", PLOS ONE, 8, pp.e80604~ (2013)[DOI]
  92. Li X, "New insights into gut-bacteria-derived indole and its derivatives in intestinal and liver diseases", Front Pharmacol, 12, pp.769501~ (2021)[DOI]
  93. Andriamihaja M, "The deleterious metabolic and genotoxic effects of the bacterial metabolite p-cresol on colonic epithelial cells", Free Radic Biol Med, 85, pp.219~227 (2015)[DOI]
  94. Windey K, "Relevance of protein fermentation to gut health", Mol Nutr Food Res, 56, pp.184~196 (2011)[DOI]
  95. Liang H, "Dietary L-tryptophan modulates the structural and functional composition of the intestinal microbiome in weaned piglets", Front Microbiol, 9, pp.1736~ (2018)[DOI]
  96. Fu Q, "Resveratrol attenuates diquat-induced oxidative stress by regulating gut microbiota and metabolome characteristics in piglets", Front Microbiol, 12, pp.695155~ (2021)[DOI]
  97. Wesoly R, "Nutritional influences on skatole formation and skatole metabolism in the pig", Animals, 2, pp.221~242 (2012)[DOI]
  98. Jensen BB., "Prevention of boar taint in pig production. Factors affecting the level of skatole", Acta Vet Scand, 48, pp.S6~ (2006)[DOI]
  99. Pieper R, "Interaction between dietary protein content and the source of carbohydrates along the gastrointestinal tract of weaned piglets", Arch Anim Nutr, 68, pp.263~280 (2014)[DOI]
  100. De Bruyne E, "Oral glutathione supplementation drastically reduces Helicobacter-induced gastric pathologies", Sci Rep, 6, pp.20169~ (2016)[DOI]
  101. Zhang G, "Effects of helicobacter suis γ-glutamyl transpeptidase on lymphocytes : modulation by glutamine and glutathione supplementation and outer membrane vesicles as a putative delivery route of the enzyme", PLOS ONE, 9, pp.e77966~ (2014)[DOI]
  102. Blachier F, "Cysteine-derived hydrogen sulfide and gut health : a matter of endogenous or bacterial origin", Curr Opin Clin Nutr Metab Care, 22, pp.68~75 (2019)[DOI]
  103. Blachier F, "Fate of undigested proteins in the pig large intestine : what impact on the colon epithelium?", Anim Nutr, 9, pp.110~118 (2022)[DOI]
  104. Strandwitz P, "Neurotransmitter modulation by the gut microbiota", Brain Res, 1693, pp.128~133 (2018)[DOI]
  105. Kobek-Kjeldager C, "Diet and microbiota-gut-brain axis in relation to tail biting in pigs : a review", Appl Anim Behav Sci, 246, pp.105514~ (2022)[DOI]
  106. Henry Y, "Growth performance and brain neurotransmitters in pigs as affected by tryptophan, protein, and sex", J Anim Sci, 74, pp.2700~2710 (1996)[DOI]
  107. Saraf MK, "Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon", Microbiome, 5, pp.77~ (2017)[DOI]
  108. LeBlanc JG, "Bacteria as vitamin suppliers to their host : a gut microbiota perspective", Curr Opin Biotechnol, 24, pp.160~168 (2013)[DOI]
  109. LeBlanc JG, "B-group vitamin production by lactic acid bacteria – current knowledge and potential applications", J Appl Microbiol, 111, pp.1297~1309 (2011)[DOI]
  110. Caspani G, "Small talk : microbial metabolites involved in the signaling from microbiota to brain", Curr Opin Pharmacol, 48, pp.99~106 (2019)[DOI]
  111. Silva YP, "The role of short-chain fatty acids from gut microbiota in gut-brain communication", Front Endocrinol, 11, pp.25~ (2020)[DOI]
  112. Ríos-Covián D, "Intestinal short chain fatty acids and their link with diet and human health", Front Microbiol, 7, pp.185~ (2016)[DOI]
  113. Makki K, "The impact of dietary fiber on gut microbiota in host health and disease", Cell Host Microbe, 23, pp.705~715 (2018)[DOI]
  114. Trefflich I, "Short-and branched-chain fatty acids as fecal markers for microbiota activity in vegans and omnivores", Nutrients, 13, pp.1808~ (2021)[DOI]
  115. Macfarlane GT, "Estimation of short-chain fatty acid production from protein by human intestinal bacteria based on branched-chain fatty acid measurements", FEMS Microbiol Lett, 101, pp.81~88 (1992)[DOI]
  116. Nakatani M, "Production, absorption, and blood flow dynamics of short-chain fatty acids produced by fermentation in piglet hindgut during the suckling–weaning period", Nutrients, 10, pp.1220~ (2018)[DOI]
  117. Miller TL, "Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora", Appl Environ Microbiol, 62, pp.1589~1592 (1996)[DOI]
  118. Ragsdale SW, "Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation", Biochim Biophys Acta Proteins Proteom, 1784, pp.1873~1898 (2008)[DOI]
  119. Bai Y, "Sources of dietary fiber affect the SCFA production and absorption in the hindgut of growing pigs", Front Nutr, 8, pp.719935~ (2022)[DOI]
  120. Namkung H, "Impact of feeding blends of organic acids and herbal extracts on growth performance, gut microbiota and digestive function in newly weaned pigs", Can J Anim Sci, 84, pp.697~704 (2004)[DOI]
  121. Dotsenko G, "Enzymatic production of wheat and ryegrass derived xylooligosaccharides and evaluation of their in vitro effect on pig gut microbiota", Biomass Convers Biorefin, 8, pp.497~507 (2018)[DOI]
  122. Ju Kyoung Oh, "Multispecies probiotics alter fecal short-chain fatty acids and lactate levels in weaned pigs by modulating gut microbiota", 한국축산학회지, 63(5), pp.1142~1158 (2021), 한국축산학회[DOI]
  123. Liu H, "Butyrate : a double-edged sword for health?", Adv Nutr, 9, pp.21~29 (2018)[DOI]
  124. Yu K, "Hepatic metabolomic and transcriptomic responses induced by cecal infusion of sodium propionate in a fistula pig model", J Agric Food Chem, 67, pp.13073~13081 (2019)[DOI]
  125. Zeng H, "Metabolic control of regulatory T cell development and function", Trends Immunol, 36, pp.3~12 (2015)[DOI]
  126. Sakaguchi S, "Regulatory T cells and immune tolerance", Cell, 133, pp.775~787 (2008)[DOI]
  127. Kondělková K, "Regulatory T cells(TREG)and their roles in immune system with respect to immunopathological disorders", Acta Medica(Hradec Králové)Universitas Carolina, Facultas Medica Hradec Králové, 53, pp.73~77 (2010)[DOI]
  128. Zhang H, "Impact of fermentable protein, by feeding high protein diets, on microbial composition, microbial catabolic activity, gut health and beyond in pigs", Microorganisms, 8, pp.1735~ (2020)[DOI]
  129. Heo JM, "Feeding a diet with a decreased protein content reduces both nitrogen content in the gastrointestinal tract and post-weaning diarrhoea, but does not affect apparent nitrogen digestibility in weaner pigs challenged with an enterotoxigenic strain of Escherichia coli", Anim Feed Sci Technol, 160, pp.148~159 (2010)[DOI]
  130. He X, "An increase in corn resistant starch decreases protein fermentation and modulates gut microbiota during in vitro cultivation of pig large intestinal inocula", Anim Nutr, 3, pp.219~224 (2017)[DOI]
  131. Cho HM, "Stimbiotic supplementation improved performance and reduced inflammatory response via stimulating fiber fermenting microbiome in weaner pigs housed in a poor sanitary environment and fed an antibiotic-free low zinc oxide diet", PLOS ONE, 15, pp.e0240264~ (2020)[DOI]
  132. Wang J, "Influence of probiotics on dietary protein digestion and utilization in the gastrointestinal tract", Curr Protein Pept Sci, 20, pp.125~131 (2019)[DOI]
  133. Zeng H, "Secondary bile acids and short chain fatty acids in the colon : a focus on colonic microbiome, cell proliferation, inflammation, and cancer", Int J Mol Sci, 20, pp.1214~ (2019)[DOI]
  134. Molinero N, "Intestinal bacteria interplay with bile and cholesterol metabolism : implications on host physiology", Front Physiol, 10, pp.185~ (2019)[DOI]
  135. Jones ML, "The gut microbiome, probiotics, bile acids axis, and human health", Trends Microbiol, 22, pp.306~308 (2014)[DOI]
  136. Fan P, "Roles of biogenic amines in intestinal signaling", Curr Protein Pept Sci, 18, pp.532~540 (2017)[DOI]
  137. Wu G, "Polyamine synthesis from proline in the developing porcine placenta", Biol Reprod, 72, pp.842~850 (2005)[DOI]
  138. Nakamura A, "Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome", Gut Microbes, 10, pp.159~171 (2019)[DOI]
  139. Bekebrede AF, "The molecular and physiological effects of protein-derived polyamines in the intestine", Nutrients, 12, pp.197~ (2020)[DOI]
  140. Yu D, "Effects of long-term dietary protein restriction on intestinal morphology, digestive enzymes, gut hormones, and colonic microbiota in pigs", Animals, 9, pp.180~ (2019)[DOI]
  141. Chen X, "Moderate dietary protein restriction optimized gut microbiota and mucosal barrier in growing pig model", Front Cell Infect Microbiol, 8, pp.246~ (2018)[DOI]
  142. Zhang C, "Effect of early antibiotic administration on cecal bacterial communities and their metabolic profiles in pigs fed diets with different protein levels", Anaerobe, 42, pp.188~196 (2016)[DOI]
  143. Yu M, "Long-term effects of early antibiotic intervention on blood parameters, apparent nutrient digestibility, and fecal microbial fermentation profile in pigs with different dietary protein levels", J Anim Sci Biotechnol, 8, pp.60~ (2017)[DOI]
  144. Peng Y, "Progressive response of large intestinal bacterial community and fermentation to the stepwise decrease of dietary crude protein level in growing pigs", Appl Microbiol Biotechnol, 101, pp.5415~5426 (2017)[DOI]
  145. Wang J, "Regulatory role of L-proline in fetal pig growth and intestinal epithelial cell proliferation", Anim Nutr, 6, pp.438~446 (2020)[DOI]
  146. Liu B, "Putrescine mitigates intestinal atrophy through suppressing inflammatory response in weanling piglets", J Anim Sci Biotechnol, 10, pp.69~ (2019)[DOI]
  147. Smith EA, "Formation of phenolic and indolic compounds by anaerobic bacteria in the human large intestine", Microb Ecol, 33, pp.180~188 (1997)[DOI]
  148. Venkatesh M, "Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Tolllike receptor 4", Immunity, 41, pp.296~310 (2014)[DOI]
  149. Agus A, "Gut microbiota regulation of tryptophan metabolism in health and disease", Cell Host Microbe, 23, pp.716~724 (2018)[DOI]
  150. Liang H, "Dietary L-tryptophan supplementation enhances the intestinal mucosal barrier function in weaned piglets : implication of tryptophanmetabolizing microbiota", Int J Mol Sci, 20, pp.20~ (2019)[DOI]
  151. Kong XF, "Colonic luminal microbiota and bacterial metabolite composition in pregnant Huanjiang mini-pigs : effects of food composition at different times of pregnancy", Sci Rep, 6, pp.37224~ (2016)[DOI]
  152. Li R, "Different dietary protein sources in low protein diets regulate colonic microbiota and barrier function in a piglet model", Food Funct, 10, pp.6417~6428 (2019)[DOI]
  153. Arroyo L, "Effect of handling on neurotransmitter profile in pig brain according to fear related behaviour", Physiol Behav, 167, pp.374~381 (2016)[DOI]
  154. Moeser AJ, "Weaning stress and gastrointestinal barrier development : implications for lifelong gut health in pigs", Anim Nutr, 3, pp.313~321 (2017)[DOI]
  155. Lyte JM, "Review : microbial endocrinology : intersection of microbiology and neurobiology matters to swine health from infection to behavior", Animal, 13, pp.2689~2698 (2019)[DOI]
  156. Yano JM, "Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis", Cell, 161, pp.264~276 (2015)[DOI]
  157. Kwon YH, "Modulation of gut microbiota composition by serotonin signaling influences intestinal immune response and susceptibility to colitis", Cell Mol Gastroenterol Hepatol, 7, pp.709~728 (2019)[DOI]
  158. Li ZS, "Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor : analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice", J Neurosci, 26, pp.2798~2807 (2006)[DOI]
  159. Gao K, "Antibiotics-induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets", J Neurochem, 146, pp.219~234 (2018)[DOI]
  160. Hu J, "Gradual changes of gut microbiota in weaned miniature piglets", Front Microbiol, 7, pp.1727~ (2016)[DOI]
  161. LeBlanc JG, "Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria", Microb Cell Fact, 16, pp.79~ (2017)[DOI]
  162. Lauridsen C, "Role of vitamins for gastro-intestinal functionality and health of pigs", Anim Feed Sci Technol, 273, pp.114823~ (2021)[DOI]
  163. Yoshii K, "Metabolism of dietary and microbial vitamin b family in the regulation of host immunity", Front Nutr, 6, pp.48~ (2019)[DOI]
  164. Liao SF, "Using probiotics to improve swine gut health and nutrient utilization", Anim Nutr, 3, pp.331~343 (2017)[DOI]
  165. Roselli M, "Immunomodulating effects of probiotics for microbiota modulation, gut health and disease resistance in pigs", Anim Feed Sci Technol, 233, pp.104~119 (2017)[DOI]
  166. Daye Mun, "Effects of Bacillus-based probiotics on growth performance, nutrient digestibility, and intestinal health of weaned pigs", 한국축산학회지, 63(6), pp.1314~1327 (2021), 한국축산학회[DOI]
  167. Andrew Wange Bugenyi, "Association between oropharyngeal microbiome and weight gain in piglets during pre and post weaning life", 한국축산학회지, 62(2), pp.247~262 (2020), 한국축산학회[DOI]
  168. Min-Sung Kwon, "Alteration of the gut microbiota in post-weaned calves following recovery from bovine coronavirusmediated diarrhea", 한국축산학회지, 63(1), pp.125~136 (2021), 한국축산학회[DOI]
  169. Wang K, "The enhancement of intestinal immunity in offspring piglets by maternal probiotic or synbiotic supplementation is associated with the alteration of gut microbiota", Front Nutr, 8, pp.686053~ (2021)[DOI]
  170. Barba-Vidal E, "Review : are we using probiotics correctly in post-weaning piglets?", Animal, 12, pp.2489~2498 (2018)[DOI]
  171. Liu H, "Lactobacillus reuteri I5007 modulates intestinal host defense peptide expression in the model of IPEC-J2 cells and neonatal piglets", Nutrients, 9, pp.559~ (2017)[DOI]
  172. Xuhong Lu, "Growth Performance and Post-Weaning Diarrhea in Piglets Fed a Diet Supplemented with Probiotic Complexes", Journal of Microbiology and Biotechnology, 28(11), pp.1791~1799 (2018), 한국미생물·생명공학회
  173. Andersen AD, "Synbiotics combined with glutamine stimulate brain development and the immune system in preterm pigs", J Nutr, 149, pp.36~45 (2019)[DOI]
  174. Cao G, "Positive effects of a Clostridium butyricum-based compound probiotic on growth performance, immune responses, intestinal morphology, hypothalamic neurotransmitters, and colonic microbiota in weaned piglets", Food Funct, 10, pp.2926~2934 (2019)[DOI]
  175. Wang S, "Combined supplementation of Lactobacillus fermentum and Pediococcus acidilactici promoted growth performance, alleviated inflammation, and modulated intestinal microbiota in weaned pigs", BMC Vet Res, 15, pp.239~ (2019)[DOI]
  176. Ding H, "Dietary supplementation with Bacillus subtilis DSM 32315 alters the intestinal microbiota and metabolites in weaned piglets", J Appl Microbiol, 130, pp.217~232 (2021)[DOI]
  177. Wang X, "Dietary supplementation with Bacillus mixture modifies the intestinal ecosystem of weaned piglets in an overall beneficial way", J Appl Microbiol, 130, pp.233~246 (2021)[DOI]
  178. Wang XL, "Effects of dietary supplementation of Lactobacillus delbrueckii on gut microbiome and intestinal morphology in weaned piglets", Front Vet Sci, 8, pp.692389~ (2021)[DOI]
  179. Ma C, "Maternal probiotics supplementation improves immune and antioxidant function in suckling piglets via modifying gut microbiota", J Appl Microbiol (2022)[DOI]
  180. He T, "Lactobacillus johnsonii L531 reduces pathogen load and helps maintain short-chain fatty acid levels in the intestines of pigs challenged with Salmonella enterica infantis", Vet Microbiol, 230, pp.187~194 (2019)[DOI]
  181. Sakata T, "Influences of probiotic bacteria on organic acid production by pig caecal bacteria in vitro", Proc Nutr Soc, 62, pp.73~80 (2003)[DOI]
  182. Ohashi Y, "Health-beneficial effects of probiotics : its mode of action", Anim Sci J, 80, pp.361~371 (2009)[DOI]
  183. El Aidy S, "The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation", Gut, 62, pp.1306~1314 (2013)[DOI]
  184. Hou G, "Lactobacillus delbrueckii interfere with bile acid enterohepatic circulation to regulate cholesterol metabolism of growing–finishing pigs via its bile salt hydrolase activity", Front Nutr, 7, pp.617676~ (2020)[DOI]
  185. Nealon NJ, "Rice bran and probiotics alter the porcine large intestine and serum metabolomes for protection against human rotavirus diarrhea", Front Microbiol, 8, pp.653~ (2017)[DOI]
  186. Yang M, "Bile acid–gut microbiota axis in inflammatory bowel disease : from bench to bedside", Nutrients, 13, pp.3143~ (2021)[DOI]
  187. Degirolamo C, "Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice", Cell Rep, 7, pp.12~18 (2014)[DOI]
  188. Barba-Vidal E, "Evaluation of the probiotic strain Bifidobacterium longum subsp. infantis CECT 7210 capacities to improve health status and fight digestive pathogens in a piglet model", Front Microbiol, 8, pp.533~ (2017)[DOI]
  189. Rodríguez-Sorrento A, "Effects of the administration of Bifidobacterium longum subsp. infantis CECT 7210 and Lactobacillus rhamnosus HN001 and their synbiotic combination with galacto-oligosaccharides against enterotoxigenic Escherichia coli F4 in an early weaned piglet model", Front Microbiol, 12, pp.642549~ (2021)[DOI]
  190. Q.K. Sheng, "Effect of Bacillus subtilis Natto on Meat Quality and Skatole Content in TOPIGS Pigs", Animal Bioscience, 29(5), pp.716~721 (2016), 아세아·태평양축산학회[DOI]
  191. Peng XP, "Regulation of probiotics on metabolism of dietary protein in intestine", Curr Protein Pept Sci, 21, pp.766~771 (2020)[DOI]
  192. Yong SJ, "Antidepressive mechanisms of probiotics and their therapeutic potential", Front Neurosci, 13, pp.1361~ (2020)[DOI]
  193. Sarkar A, "Psychobiotics and the manipulation of bacteria–gut–brain signals", Trends Neurosci, 39, pp.763~781 (2016)[DOI]
  194. Cao G, "Positive effects of a : Clostridium butyricum-based compound probiotic on growth performance, immune responses, intestinal morphology, hypothalamic neurotransmitters, and colonic microbiota in weaned piglets", Food Funct, 10, pp.2926~2934 (2019)[DOI]
  195. Valent D, "Effects of a high-fat-diet supplemented with probiotics and ω3-fatty acids on appetite regulatory neuropeptides and neurotransmitters in a pig model", Benef Microbes, 11, pp.347~359 (2020)[DOI]
  196. Parois SP, "Potential improvements of the cognition of piglets through a synbiotic supplementation from 1 to 28 days via the gut microbiota", Sci Rep, 11, pp.24113~ (2021)[DOI]
  197. Nowak P, "The effect of eubiotic feed additives on the performance of growing pigs and the activity of intestinal microflora", Arch Anim Nutr, 71, pp.455~469 (2017)[DOI]
  198. Zhang J, "Dietary clostridium butyricum induces a phased shift in fecal microbiota structure and increases the acetic acid-producing bacteria in a weaned piglet model", J Agric Food Chem, 66, pp.5157~5166 (2018)[DOI]

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