Gut Microbial Metabolites on Host Immune Responses in Health and Disease

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참고문헌 (172)

1. Yang W, "Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases", Cell Mol Immunol, 18, pp.866~877 (2021)
2. Koh A, "From dietary fiber to host physiology : short-chain fatty acids as key bacterial metabolites", Cell, 165, pp.1332~1345 (2016)
3. van der Hee B, "Microbial regulation of host physiology by short-chain fatty acids", Trends Microbiol, 29, pp.700~712 (2021)
4. Chambers ES, "Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults", Gut, 64, pp.1744~1754 (2015)
5. Samuel BS, "Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41", Proc Natl Acad Sci U S A, 105, pp.16767~16772 (2008)
6. 박정우, "Short-chain Fatty Acids Inhibit Staphylococcal Lipoprotein-induced Nitric Oxide Production in Murine Macrophages", Immune Network, 19(2), pp.1~13 (2019), 대한면역학회
7. Zhu Z, "Short-chain fatty acids as a target for prevention against food allergy by regulatory T cells", JGH Open, 3, pp.190~195 (2019)
8. Zhou L, "Faecalibacterium prausnitzii produces butyrate to maintain Th17", Treg balance and to ameliorate colorectal colitis by inhibiting histone deacetylase 1, 2018, pp.24, 1926~1940
9. Huang J, "Gut microbial metabolites alter IgA immunity in type 1 diabetes", JCI Insight, 5, pp.e135718~ (2020)
10. Juanola O, "Regulatory T cells restrict permeability to bacterial antigen translocation and preserve short-chain fatty acids in experimental cirrhosis", Hepatol Commun, 2, pp.1610~1623 (2018)
11. Hu M, "Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia", Nat Commun, 10, pp.3031~ (2019)
12. den Besten G, "The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism", J Lipid Res, 54, pp.2325~2340 (2013)
13. Rey FE, "Dissecting the in vivo metabolic potential of two human gut acetogens", J Biol Chem, 285, pp.22082~22090 (2010)
14. Louis P, "The gut microbiota, bacterial metabolites and colorectal cancer", Nat Rev Microbiol, 12, pp.661~672 (2014)
15. Chiang JY, "Bile acid metabolism and signaling", Compr Physiol, 3, pp.1191~1212 (2013)
16. Russell DW, "The enzymes, regulation, and genetics of bile acid synthesis", Annu Rev Biochem, 72, pp.137~174 (2003)
17. Molinaro A, "Role of bile acids in metabolic control", Trends Endocrinol Metab, 29, pp.31~41 (2018)
18. Fuchs CD, "Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology", Nat Rev Gastroenterol Hepatol, 19, pp.432~450 (2022)
19. Di Ciaula A, "Bile acid physiology", Ann Hepatol, 16, pp.s4~s14 (2017)
20. Guzior DV, "Review : microbial transformations of human bile acids", Microbiome, 9, pp.140~ (2021)
21. Sayin SI, "Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist", Cell Metab, 17, pp.225~235 (2013)
22. Chiang JY, "Negative feedback regulation of bile acid metabolism : impact on liver metabolism and diseases", Hepatology, 62, pp.1315~1317 (2015)
23. Ridlon JM, "Consequences of bile salt biotransformations by intestinal bacteria", Gut Microbes, 7, pp.22~39 (2016)
24. Ridlon JM, "Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium", J Lipid Res, 53, pp.66~76 (2012)
25. Ridlon JM, "Bile salt biotransformations by human intestinal bacteria", J Lipid Res, 47, pp.241~259 (2006)
26. Paik D, "Human gut bacteria produce TH17-modulating bile acid metabolites", Nature, 603, pp.907~912 (2022)
27. Li W, "A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1", Cell Host Microbe, 29, pp.1366~1377 (2021)
28. Aguirre AM, "Bile acid-independent protection against Clostridioides difficile infection", PLoS Pathog, 17, pp.e1010015~ (2021)
29. Urdaneta V, "Interactions between bacteria and bile salts in the gastrointestinal and hepatobiliary tracts", Front Med(Lausanne), 4, pp.163~ (2017)
30. Li J, "Polyamines and related signaling pathways in cancer", Cancer Cell Int, 20, pp.539~ (2020)
31. Larqué E, "Biological significance of dietary polyamines", Nutrition, 23, pp.87~95 (2007)
32. Thomas T, "Polyamines in cell growth and cell death : molecular mechanisms and therapeutic applications", Cell Mol Life Sci, 58, pp.244~258 (2001)
33. Nakanishi S, "Polyamine homeostasis in development and disease", Med Sci(Basel), 9, pp.28~ (2021)
34. Moinard C, "Polyamines : metabolism and implications in human diseases", Clin Nutr, 24, pp.184~197 (2005)
35. Tofalo R, "Polyamines and gut microbiota", Front Nutr, 6, pp.16~ (2019)
36. Igarashi K, "Characteristics of cellular polyamine transport in prokaryotes and eukaryotes", Plant Physiol Biochem, 48, pp.506~512 (2010)
37. Sugiyama Y, "Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria : potential presence of novel polyamine metabolism and transport genes", Int J Biochem Cell Biol, 93, pp.52~61 (2017)
38. Burrell M, "Evolution and multiplicity of arginine decarboxylases in polyamine biosynthesis and essential role in Bacillus subtilis biofilm formation", J Biol Chem, 285, pp.39224~39238 (2010)
39. Suárez C, "Expression of the agmatine deiminase pathway in Enterococcus faecalis is activated by the AguR regulator and repressed by CcpA and PTSMan systems", PLoS One, 8, pp.e76170~ (2013)
40. Hanfrey CC, "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota", J Biol Chem, 286, pp.43301~43312 (2011)
41. Nakamura A, "Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome", Gut Microbes, 10, pp.159~171 (2019)
42. Kitada Y, "Bioactive polyamine production by a novel hybrid system comprising multiple indigenous gut bacterial strategies", Sci Adv, 4, pp.eaat0062~ (2018)
43. Kibe R, "Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice", Sci Rep, 4, pp.4548~ (2014)
44. Matsumoto M, "Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production", PLoS One, 6, pp.e23652~ (2011)
45. Matsumoto M, "Endothelial function is improved by inducing microbial polyamine production in the gut : a randomized placebo-controlled trial", Nutrients, 11, pp.11~ (2019)
46. Chevalier C, "Warmth prevents bone loss through the gut microbiota", Cell Metab, 32, pp.575~590 (2020)
47. Zhao Q, "Polyamine metabolism links gut microbiota and testicular dysfunction", Microbiome, 9, pp.224~ (2021)
48. Noack J, "Dietary guar gum and pectin stimulate intestinal microbial polyamine synthesis in rats", J Nutr, 128, pp.1385~1391 (1998)
49. Noack J, "The human gut bacteria Bacteroides thetaiotaomicron and Fusobacterium varium produce putrescine and spermidine in cecum of pectin-fed gnotobiotic rats", J Nutr, 130, pp.1225~1231 (2000)
50. Ma L, "Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice", Gut Microbes, 12, pp.1~19 (2020)
51. Lin MY, "Redirection of epithelial immune responses by short-chain fatty acids through inhibition of histone deacetylases", Front Immunol, 6, pp.554~ (2015)
52. Schulthess J, "The short chain fatty acid butyrate imprints an antimicrobial program in macrophages", Immunity, 50, pp.432~445 (2019)
53. Smith PM, "The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis", Science, 341, pp.569~573 (2013)
54. Furusawa Y, "Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells", Nature, 504, pp.446~450 (2013)
55. Arpaia N, "Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation", Nature, 504, pp.451~455 (2013)
56. Antunes KH, "Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response", Nat Commun, 10, pp.3273~ (2019)
57. Trompette A, "Dietary fiber confers protection against flu by shaping Ly6c-patrolling monocyte hematopoiesis and CD8+ T cell metabolism", Immunity, 48, pp.992~1005 (2018)
58. Sencio V, "Gut dysbiosis during influenza contributes to pulmonary pneumococcal superinfection through altered short-chain fatty acid production", Cell Reports, 30, pp.2934~2947 (2020)
59. Luu M, "Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer", Nat Commun, 12, pp.4077~ (2021)
60. Yang W, "Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity", Nat Commun, 11, pp.4457~ (2020)
61. Sanchez HN, "B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids", Nat Commun, 11, pp.60~ (2020)
62. Jansen PL, "The ascending pathophysiology of cholestatic liver disease", Hepatology, 65, pp.722~738 (2017)
63. Song P, "Dose-response of five bile acids on serum and liver bile acid concentrations and hepatotoxicty in mice", Toxicol Sci, 123, pp.359~367 (2011)
64. Galle PR, "Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes", Hepatology, 12, pp.486~491 (1990)
65. Hofmann AF, "Physicochemical properties of bile acids and their relationship to biological properties : an overview of the problem", J Lipid Res, 25, pp.1477~1489 (1984)
66. Fiorucci S, "Immunomodulatory functions of FXR", Mol Cell Endocrinol, 551, pp.111650~ (2022)
67. Zhou J, "SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis", Nat Commun, 11, pp.240~ (2020)
68. Zhang MY, "FXR expression in rats of hilar cholangiocarcinoma", Sci Rep, 12, pp.8741~ (2022)
69. Miyazaki T, "Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis", Sci Rep, 11, pp.492~ (2021)
70. Vavassori P, "The bile acid receptor FXR is a modulator of intestinal innate immunity", J Immunol, 183, pp.6251~6261 (2009)
71. Kliewer SA, "An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway", Cell, 92, pp.73~82 (1998)
72. Staudinger JL, "The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity", Proc Natl Acad Sci U S A, 98, pp.3369~3374 (2001)
73. Maruyama T, "Identification of membrane-type receptor for bile acids(M-BAR)", Biochem Biophys Res Commun, 298, pp.714~719 (2002)
74. Shi Y, "TGR5 regulates macrophage inflammation in nonalcoholic steatohepatitis by modulating NLRP3 inflammasome activation", Front Immunol, 11, pp.609060~ (2021)
75. Pols TW, "The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation", J Hepatol, 54, pp.1263~1272 (2011)
76. Portincasa P, "Bile acids and gpbar-1 : dynamic interaction involving genes, environment and gut microbiome", Nutrients, 12, pp.3790~ (2020)
77. Nagahashi M, "The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases", J Lipid Res, 57, pp.1636~1643 (2016)
78. Campbell C, "FXR mediates T cell-intrinsic responses to reduced feeding during infection", Proc Natl Acad Sci U S A, 117, pp.33446~33454 (2020)
79. Wilson A, "Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease", Sci Rep, 10, pp.1866~ (2020)
80. Gadaleta RM, "Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease", Gut, 60, pp.463~472 (2011)
81. Mencarelli A, "The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis", J Immunol, 183, pp.6657~6666 (2009)
82. Guillot A, "Bile acid-activated macrophages promote biliary epithelial cell proliferation through integrin αvβ6 upregulation following liver injury", J Clin Invest, 131, pp.e132305~ (2021)
83. Wammers M, "Reprogramming of pro-inflammatory human macrophages to an anti-inflammatory phenotype by bile acids", Sci Rep, 8, pp.255~ (2018)
84. Biagioli M, "Gpbar1 functions as gatekeeper for liver NKT cells and provides counterregulatory signals in mouse models of immune-mediated hepatitis", Cell Mol Gastroenterol Hepatol, 8, pp.447~473 (2019)
85. Cipriani S, "The bile acid receptor GPBAR-1(TGR5)modulates integrity of intestinal barrier and immune response to experimental colitis", PLoS One, 6, pp.e25637~ (2011)
86. Biagioli M, "The bile acid receptor gpbar1 regulates the M1", M2 phenotype of intestinal macrophages and activation of GPBAR1 rescues mice from murine colitis, 2017, pp.199, 718~733
87. Hu J, "Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling", Cell Reports, 36, pp.109726~ (2021)
88. Keitel V, "Expression and function of the bile acid receptor TGR5 in Kupffer cells", Biochem Biophys Res Commun, 372, pp.78~84 (2008)
89. Ding C, "Bile acid restrained T cell activation explains cholestasis aggravated hepatitis B virus infection", FASEB J, 36, pp.e22468~ (2022)
90. Pols TW, "Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor", PLoS One, 12, pp.e0176715~ (2017)
91. Shi Z, "Bile acids improve psoriasiform dermatitis through inhibition of IL-17A expression and CCL20-CCR6-mediated trafficking of T cells", J Invest Dermatol, 142, pp.1381~1390 (2022)
92. Song X, "Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis", Nature, 577, pp.410~415 (2020)
93. Hang S, "Bile acid metabolites control TH17 and Treg cell differentiation", Nature, 576, pp.143~148 (2019)
94. Campbell C, "Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells", Nature, 581, pp.475~479 (2020)
95. Banerji R, "Polyamines in the virulence of bacterial pathogens of respiratory tract", Mol Oral Microbiol, 36, pp.1~11 (2021)
96. Rollins-Smith LA, "Metabolites involved in immune evasion by Batrachochytrium dendrobatidis include the polyamine spermidine", Infect Immun, 87, pp.e00035~ (2019)
97. Firpo MR, "Targeting polyamines inhibits coronavirus infection by reducing cellular attachment and entry", ACS Infect Dis, 7, pp.1423~1432 (2021)
98. Hardbower DM, "Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications", Proc Natl Acad Sci U S A, 114, pp.E751~ (2017)
99. Puleston DJ, "New roles for autophagy and spermidine in T cells", Microb Cell, 2, pp.91~93 (2015)
100. Rossi G, "Effects of probiotic bacteria on mucosal polyamines levels in dogs with IBD and colonic polyps : a preliminary study", Benef Microbes, 9, pp.247~255 (2018)
101. Puntambekar SS, "LPS-induced CCL2 expression and macrophage influx into the murine central nervous system is polyamine-dependent", Brain Behav Immun, 25, pp.629~639 (2011)
102. Zhang M, "Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells : a counterregulatory mechanism that restrains the immune response", J Exp Med, 185, pp.1759~1768 (1997)
103. Cao W, "New insights into the role of dietary spermine on inflammation, immune function and related-signalling molecules in the thymus and spleen of piglets", Arch Anim Nutr, 71, pp.175~191 (2017)
104. Zhu S, "Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers", Mol Med, 15, pp.275~282 (2009)
105. Li G, "Spermidine suppresses inflammatory DC function by activating the FOXO3 pathway and counteracts autoimmunity", iScience, 23, pp.100807~ (2020)
106. Puleston DJ, "Polyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation", Cell Metab, 30, pp.352~363 (2019)
107. 정진우, "Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish", Biomolecules & Therapeutics, 26(2), pp.146~156 (2018), 한국응용약물학회
108. Zhang H, "Polyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence", Mol Cell, 76, pp.110~125 (2019)
109. Pandiyan P, "Microbiome dependent regulation of Tregs and Th17 cells in mucosa", Front Immunol, 10, pp.426~ (2019)
110. Li H, "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers", Proc Natl Acad Sci U S A, 100, pp.8412~8417 (2003)
111. Suzuki T, "Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability", Br J Nutr, 100, pp.297~305 (2008)
112. Singh N, "Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis", Immunity, 40, pp.128~139 (2014)
113. Brown AJ, "The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids", J Biol Chem, 278, pp.11312~11319 (2003)
114. Maslowski KM, "Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43", Nature, 461, pp.1282~1286 (2009)
115. Kang HJ, "Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3+ regulatory T cells", J Allergy Clin Immunol, 147, pp.1517~1521 (2021)
116. Krautkramer KA, "Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues", Mol Cell, 64, pp.982~992 (2016)
117. Candido EP, "Sodium butyrate inhibits histone deacetylation in cultured cells", Cell, 14, pp.105~113 (1978)
118. Park J, "Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway", Mucosal Immunol, 8, pp.80~93 (2015)
119. Coutzac C, "Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer", Nat Commun, 11, pp.2168~ (2020)
120. Puleston DJ, "Polyamine metabolism is a central determinant of helper T cell lineage fidelity", Cell, 184, pp.4186~4202 (2021)
121. Wagner A, "Metabolic modeling of single Th17 cells reveals regulators of autoimmunity", Cell, 184, pp.4168~4185 (2021)
122. Mondanelli G, "A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells", Immunity, 46, pp.233~244 (2017)
123. Carriche GM, "Regulating T-cell differentiation through the polyamine spermidine", J Allergy Clin Immunol, 147, pp.335~348 (2021)
124. Trapecar M, "Gut-liver physiomimetics reveal paradoxical modulation of IBD-related inflammation by short-chain fatty acids", Cell Syst, 10, pp.223~239 (2020)
125. Behary J, "Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma", Nat Commun, 12, pp.187~ (2021)
126. Du HX, "Gut microflora modulates Th17", Treg cell differentiation in experimental autoimmune prostatitis via the short-chain fatty acid propionate, 2022, pp.13, 915218~
127. Scheppach W, "Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis", Gastroenterology, 103, pp.51~56 (1992)
128. Harig JM, "Treatment of diversion colitis with short-chain-fatty acid irrigation", N Engl J Med, 320, pp.23~28 (1989)
129. Segain JP, "Butyrate inhibits inflammatory responses through NFκB inhibition : implications for Crohn’s disease", Gut, 47, pp.397~403 (2000)
130. Bäckhed F, "Mechanisms underlying the resistance to diet-induced obesity in germ-free mice", Proc Natl Acad Sci U S A, 104, pp.979~984 (2007)
131. Wang Z, "Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease", Nature, 472, pp.57~63 (2011)
132. Zhu W, "Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk", Cell, 165, pp.111~124 (2016)
133. De Vadder F, "Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits", Cell, 156, pp.84~96 (2014)
134. Buffington SA, "Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring", Cell, 165, pp.1762~1775 (2016)
135. Trompette A, "Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis", Nat Med, 20, pp.159~166 (2014)
136. Ye Z, "A metagenomic study of the gut microbiome in Behcet’s disease", Microbiome, 6, pp.135~ (2018)
137. Ma C, "Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells", Science, 360 (2018)
138. Lee CK, "Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation", Science, 363, pp.644~649 (2019)
139. Fu T, "FXR regulates intestinal cancer stem cell proliferation", Cell, 176, pp.1098~1112 (2019)
140. Fiorucci S, "Obeticholic acid : an update of its pharmacological activities in liver disorders", Handb Exp Pharmacol, 256, pp.283~295 (2019)
141. Vang S, "The unexpected uses of urso-and tauroursodeoxycholic acid in the treatment of non-liver diseases", Glob Adv Health Med, 3, pp.58~69 (2014)
142. Daruich A, "Oral ursodeoxycholic acid crosses the blood retinal barrier in patients with retinal detachment and protects against retinal degeneration in an ex vivo model", Neurotherapeutics, 18, pp.1325~1338 (2021)
143. Neuschwander-Tetri BA, "Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis(FLINT) : a multicentre, randomised, placebo-controlled trial", Lancet, 385, pp.956~965 (2015)
144. Weingarden AR, "Ursodeoxycholic acid inhibits clostridium difficile spore germination and vegetative growth, and prevents recurrence of ileal pouchitis associated with the infection", J Clin Gastroenterol, 50, pp.624~630 (2016)
145. Lindor KD, "High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis", Hepatology, 50, pp.808~814 (2009)
146. Mousa OY, "Bile acid profiles in primary sclerosing cholangitis and their ability to predict hepatic decompensation", Hepatology, 74, pp.281~295 (2021)
147. Kowdley KV, "A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis", Hepatology, 67, pp.1890~1902 (2018)
148. Liu R, "Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy", Free Radic Biol Med, 161, pp.339~350 (2020)
149. Baier J, "Arginase impedes the resolution of colitis by altering the microbiome and metabolome", J Clin Invest, 130, pp.5703~5720 (2020)
150. Guo X, "Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis", Invest Ophthalmol Vis Sci, 52, pp.2696~2703 (2011)
151. Yang Q, "Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages", Cell Death Differ, 23, pp.1850~1861 (2016)
152. Kim HA, "Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever", Lupus, 27, pp.930~938 (2018)
153. Wang X, "The effect of polyamines on the binding of anti-DNA antibodies from patients with SLE and normal human subjects", Clin Immunol, 153, pp.94~103 (2014)
154. Furumitsu Y, "Levels of urinary polyamines in patients with rheumatoid arthritis", J Rheumatol, 20, pp.1661~1665 (1993)
155. Yukioka K, "Polyamine levels in synovial tissues and synovial fluids of patients with rheumatoid arthritis", J Rheumatol, 19, pp.689~692 (1992)
156. Iezaki T, "Amelioration by the natural polyamine spermine of cartilage and bone destruction in rats with collagen-induced arthritis", J Pharmacol Sci, 119, pp.107~111 (2012)
157. Karouzakis E, "Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts", Arthritis Rheum, 64, pp.1809~1817 (2012)
158. Klein K, "Epigenetics in rheumatoid arthritis", Curr Opin Rheumatol, 27, pp.76~82 (2015)
159. Moreno B, "Preclinical studies of methylthioadenosine for the treatment of multiple sclerosis", Mult Scler, 16, pp.1102~1108 (2010)
160. Moreno B, "Methylthioadenosine reverses brain autoimmune disease", Ann Neurol, 60, pp.323~334 (2006)
161. Wu R, "De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function", Sci Adv, 6 (2020)
162. Brown CT, "Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes", PLoS One, 6, pp.e25792~ (2011)
163. Böttcher MF, "Microflora-associated characteristics in faeces from allergic and nonallergic infants", Clin Exp Allergy, 30, pp.1590~1596 (2000)
164. Sinha SR, "Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation", Cell Host Microbe, 27, pp.659~670 (2020)
165. Bazzari FH, "Chenodeoxycholic acid ameliorates alcl3-induced Alzheimer’s disease neurotoxicity and cognitive deterioration via enhanced insulin signaling in rats", Molecules, 24, pp.1992~ (2019)
166. Hu J, "Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling", Cell Reports, 36, pp.109726~ (2021)
167. Liu H, "Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation", J Transl Med, 18, pp.382~ (2020)
168. Mikó E, "Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness", Biochim Biophys Acta Bioenerg, 1859, pp.958~974 (2018)
169. Lepercq P, "Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by Clostridium baratii isolated from human feces", FEMS Microbiol Lett, 235, pp.65~72 (2004)
170. Ridlon JM, "Consequences of bile salt biotransformations by intestinal bacteria", Gut Microbes, 7, pp.22~39 (2016)
171. Zhang H, "Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis", Cell Death Dis, 7, pp.207~ (2021)
172. Mueller M, "Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity", J Hepatol, 62, pp.1398~1404 (2015)

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