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Protective effects of biological feed additives on gut microbiota and the health of pigs exposed to deoxynivalenol: a review

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초록

Deoxynivalenol (DON) is the most common mycotoxin contaminant of cereal-based food and animal feed. The toxicity of DON is very low compared to that of other toxins; however, the most prominent signs of DON exposure include inappetence and body weight loss, which causes considerable economic losses in the livestock industry. This review summarizes critical studies on biological DON mycotoxin mitigation strategies and the respective in vitro and in vivo intestinal effects. Focus areas include growth performance, gut health in terms of intestinal histomorphology, epithelial barrier functions, the intestinal immune system and microflora, and short-chain fatty acid production in the intestines. In addition, DON detoxification and modulation of these parameters, through biological supplements, are discussed. Biological detoxification of DON using microorganisms can attenuate DON toxicity by modulating gut microbiota and improving gut health with or without influencing the growth performance of pigs. However, the use of microorganisms as feed additives to livestock for mycotoxins detoxification needs more research before commercial use.

Abstract

Deoxynivalenol (DON) is the most common mycotoxin contaminant of cereal-based food and animal feed. The toxicity of DON is very low compared to that of other toxins; however, the most prominent signs of DON exposure include inappetence and body weight loss, which causes considerable economic losses in the livestock industry. This review summarizes critical studies on biological DON mycotoxin mitigation strategies and the respective in vitro and in vivo intestinal effects. Focus areas include growth performance, gut health in terms of intestinal histomorphology, epithelial barrier functions, the intestinal immune system and microflora, and short-chain fatty acid production in the intestines. In addition, DON detoxification and modulation of these parameters, through biological supplements, are discussed. Biological detoxification of DON using microorganisms can attenuate DON toxicity by modulating gut microbiota and improving gut health with or without influencing the growth performance of pigs. However, the use of microorganisms as feed additives to livestock for mycotoxins detoxification needs more research before commercial use.

참고문헌 (84)

  1. de Almeida AP, "Occurrence of deoxynivalenol in wheat flour, instant noodle and biscuits commercialised in Brazil", Food Addit Contam Part B Surveill, 9, pp.251~255 (2016)[DOI]
  2. Zhao H, "Natural occurrence of deoxynivalenol in soy sauces consumed in China", Food Control, 29, pp.71~75 (2013)[DOI]
  3. Sobrova P, "Deoxynivalenol and its toxicity", Interdiscip Toxicol, 3, pp.94~99 (2010)[DOI]
  4. Smith MC, "Natural co-occurrence of mycotoxins in foods and feeds and their in vitro combined toxicological effects", Toxins, 8, pp.94~ (2016)[DOI]
  5. Guerre P, "Mycotoxin and gut microbiota interactions", Toxins, 12, pp.769~ (2020)[DOI]
  6. Pestka JJ, "Deoxynivalenol : toxicity, mechanisms and animal health risks", Anim Feed Sci Technol, 137, pp.283~298 (2007)[DOI]
  7. Diesing AK, "Mycotoxin deoxynivalenol(DON)mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1and IPEC-J2", Toxicol Lett, 200, pp.8~18 (2011)[DOI]
  8. Nossol C, "Deoxynivalenol affects cell metabolism and increases protein biosynthesis in intestinal porcine epithelial cells(IPEC-J2) : DON increases protein biosynthesis", Toxins, 10, pp.464~ (2018)[DOI]
  9. Pestka JJ, "Deoxynivalenol-induced proinflammatory gene expression : mechanisms and pathological sequelae", Toxins, 2, pp.1300~1317 (2010)[DOI]
  10. Pinton P, "Effect of deoxynivalenol and other Type B trichothecenes on the intestine : a review", Toxins, 6, pp.1615~1643 (2014)[DOI]
  11. Oswald IP, "Role of intestinal epithelial cells in the innate immune defence of the pig intestine", Vet Res, 37, pp.359~368 (2006)[DOI]
  12. Springler A, "Early activation of MAPK p44", 42is partially involved in DON-induced disruption of the intestinal barrier function and tight junction network, 2016, pp.8, 264~
  13. Jia R, "Low doses of individual and combined deoxynivalenol and zearalenone in naturally moldy diets impair intestinal functions via inducing inflammation and disrupting epithelial barrier in the intestine of piglets", Toxicol Lett, 333, pp.159~169 (2020)[DOI]
  14. Halász A, "Decontamination of mycotoxin-containing food and feed by biodegradation", Food Rev Int, 25, pp.284~298 (2009)[DOI]
  15. Hathout AS, "Biological detoxification of mycotoxins : a review", Ann Microbiol, 64, pp.905~919 (2014)[DOI]
  16. Zhu Y, "Innovative technologies for the mitigation of mycotoxins in animal feed and ingredients : a review of recent patents", Anim Feed Sci Technol, 216, pp.19~29 (2016)[DOI]
  17. Awad WA, "Decontamination and detoxification strategies for the Fusarium mycotoxin deoxynivalenol in animal feed and the effectiveness of microbial biodegradation", Food Addit Contam Part A, 27, pp.510~520 (2010)[DOI]
  18. Holanda DM, "Mycotoxin occurrence, toxicity, and detoxifying agents in pig production with an emphasis on deoxynivalenol", Toxins, 13, pp.171~ (2021)[DOI]
  19. Shima J, "Novel detoxification of the trichothecene mycotoxin deoxynivalenol by a soil bacterium isolated by enrichment culture", Appl Environ Microbiol, 63, pp.3825~3830 (1997)[DOI]
  20. Yu H, "Isolation of deoxynivalenol-transforming bacteria from the chicken intestines using the approach of PCR-DGGE guided microbial selection", BMC Microbiol, 10, pp.182~ (2010)[DOI]
  21. Wang G, "Metabolomics-guided analysis reveals a twostep epimerization of deoxynivalenol catalyzed by the bacterial consortium IFSN-C1", Appl Microbiol Biotechnol, 104, pp.6045~6056 (2020)[DOI]
  22. Schatzmayr G, "The mycotoxin factbook, food feed top", pp.363~375 (2006), Wageningen Academic
  23. Gresse R, "Gut microbiota dysbiosis in postweaning piglets : understanding the keys to health", Trends Microbiol, 25, pp.851~873 (2017)[DOI]
  24. Accensi F, "Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets", J Anim Sci, 84, pp.1935~1942 (2006)[DOI]
  25. Alizadeh A, "Deoxynivalenol impairs weight gain and affects markers of gut health after low-dose, short-term exposure of growing pigs", Toxins, 7, pp.2071~2095 (2015)[DOI]
  26. Holanda DM, "Efficacy of mycotoxin detoxifiers on health and growth of newlyweaned pigs under chronic dietary challenge of deoxynivalenol", Toxins, 12, pp.311~ (2020)[DOI]
  27. Wang S, "Deoxynivalenol impairs porcine intestinal host defense peptide expression in weaned piglets and IPEC-J2 cells", Toxins, 10, pp.541~ (2018)[DOI]
  28. Wellington MO, "Effect of long-term feeding of graded levels of deoxynivalenol (DON) on growth performance, nutrient utilization, and organ health in finishing pigs and DON content in biological samples", J Anim Sci, 98, pp.skaa378~ (2020)[DOI]
  29. Wu L, "Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol(DON)-challenged growing pigs", BMC Vet Res, 11, pp.144~ (2015)[DOI]
  30. Reddy KE, "Effects of high levels of deoxynivalenol and zearalenone on growth performance, and hematological and immunological parameters in pigs", Toxins, 10, pp.114~ (2018)[DOI]
  31. Young LG, "Vomitoxin in corn fed to young pigs", J Anim Sci, 57, pp.655~664 (1983)[DOI]
  32. Dersjant-Li Y, "The impact of low concentrations of aflatoxin, deoxynivalenol or fumonisin in diets on growing pigs and poultry", Nutr Res Rev, 16, pp.223~239 (2003)[DOI]
  33. Li X, "Protective effects of Devosia sp. ANSB714 on growth performance, immunity function, antioxidant capacity and tissue residues in growingfinishing pigs fed with deoxynivalenol contaminated diets", Food Chem Toxicol, 121, pp.246~251 (2018)[DOI]
  34. Sayyari A, "Effects and biotransformation of the mycotoxin deoxynivalenol in growing pigs fed with naturally contaminated pelleted grains with and without the addition of Coriobacteriaceum DSM 11798", Food Addit Contam Part A, 35, pp.1394~1409 (2018)[DOI]
  35. Liu M, "Effects of deoxynivalenol on the porcine growth performance and intestinal microbiota and potential remediation by a modified HSCAS binder", Food Chem Toxicol, 141, pp.111373~ (2020)[DOI]
  36. Weaver AC, "Protective effect of two yeast based feed additives on pigs chronically exposed to deoxynivalenol and zearalenone", Toxins, 6, pp.3336~3353 (2014)[DOI]
  37. Franco TS, "Lactic acid bacteria in the inhibition of Fusarium graminearum and deoxynivalenol detoxification", J Appl Microbiol, 111, pp.739~748 (2011)[DOI]
  38. Chlebicz A, "In vitro detoxification of aflatoxin B1, deoxynivalenol, fumonisins, T-2 toxin and zearalenone by probiotic bacteria from genus Lactobacillus and Saccharomyces cerevisiae yeast", Probiotics Antimicrob Proteins, 12, pp.289~301 (2020)[DOI]
  39. Li E, "Mechanisms of deoxynivalenol-induced endocytosis and degradation of tight junction proteins in jejunal IPEC-J2 cells involve selective activation of the MAPK pathways", Arch Toxicol, 95, pp.2065~2079 (2021)[DOI]
  40. Jia R, "Protective effects of Bacillus subtilis ASAG 216 on growth performance, antioxidant capacity, gut microbiota and tissues residues of weaned piglets fed deoxynivalenol contaminated diets", Food Chem Toxicol, 148, pp.111962~ (2021)[DOI]
  41. Li F, "Effects of adding Clostridium sp. WJ06 on intestinal morphology and microbial diversity of growing pigs fed with natural deoxynivalenol contaminated wheat", Toxins, 9, pp.383~ (2017)[DOI]
  42. Obremski K, "Histological estimation of the small intestine wall after administration of feed containing deoxynivalenol, T-2 toxin and zearalenone in the pig", Pol J Vet Sci, 11, pp.339~345 (2008)
  43. Bracarense APFL, "Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets", Br J Nutr, 107, pp.1776~1786 (2012)[DOI]
  44. Kolf-Clauw M, "Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol : histopathological analysis", Toxicol In Vitro, 23, pp.1580~1584 (2009)[DOI]
  45. Wang X, "Deoxynivalenol induces inflammatory injury in IPEC-J2 cells via NF-κB signaling pathway", Toxins, 11, pp.733~ (2019)[DOI]
  46. Alassane-Kpembi I, "1H-NMR metabolomics response to a realistic diet contamination with the mycotoxin deoxynivalenol : effect of probiotics supplementation", Food Chem Toxicol, 138, pp.111222~ (2020)[DOI]
  47. Maidana LG, "Lactobacillus plantarum culture supernatants improve intestinal tissue exposed to deoxynivalenol", Exp Toxicol Pathol, 69, pp.666~671 (2017)[DOI]
  48. Xiao H, "Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol : II. Intestinal morphology and function", J Anim Sci, 91, pp.4750~4756 (2013)[DOI]
  49. Schoultz I, "The intestinal barrier and current techniques for the assessment of gut permeability", Cells, 9, pp.1909~ (2020)[DOI]
  50. Goossens J, "Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2toxin promotes transepithelial passage of doxycycline and paromomycin", BMC Vet Res, 8, pp.245~ (2012)[DOI]
  51. Diesing AK, "Gene regulation of intestinal porcine epithelial cells IPEC-J2 is dependent on the site of deoxynivalenol toxicological action", PLOS ONE, 7, pp.e34136~ (2012)[DOI]
  52. Pinton P, "The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression", Toxicol Appl Pharmacol, 237, pp.41~48 (2009)[DOI]
  53. Pomothy JM, "The impact of fermented wheat germ extract on porcine epithelial cell line exposed to deoxynivalenol and T-2 mycotoxins", Oxid Med Cell Longev, 2020, pp.3854247~ (2020)[DOI]
  54. Chaithanya Chelakkot, "Mechanisms regulating intestinal barrier integrity and its pathological implications", Experimental and Molecular Medicine, 50, pp.1~9 (2018), 생화학분자생물학회
  55. Suzuki T, "Regulation of the intestinal barrier by nutrients : the role of tight junctions", Anim Sci J, 91, pp.e13357~ (2020)[DOI]
  56. Pinton P, "Toxicity of deoxynivalenol and its acetylated derivatives on the intestine : differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases", Toxicol Sci, 130, pp.180~190 (2012)[DOI]
  57. 구민정, "Bacillus subtilis Protects Porcine Intestinal Barrier from Deoxynivalenol via Improved Zonula Occludens-1 Expression", Animal Bioscience, 27(4), pp.580~586 (2014), 아세아·태평양축산학회[DOI]
  58. Lessard M, "Impact of deoxynivalenol(DON)contaminated feed on intestinal integrity and immune response in swine", Food Chem Toxicol, 80, pp.7~16 (2015)[DOI]
  59. Gao X, "Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9", Food Chem Toxicol, 112, pp.310~319 (2018)[DOI]
  60. Kariyawasam Majuwana Gamage Menaka Menike Kariyawasam, "Probiotic Properties of Lactobacillus brevis KU200019 and Synergistic Activity with Fructooligosaccharides in Antagonistic Activity against Foodborne Pathogens", 한국축산식품학회지, 40(2), pp.297~310 (2020), 한국축산식품학회[DOI]
  61. Alassane-Kpembi I, "Saccharomyces cerevisiae boulardii reduces the deoxynivalenol-induced alteration of the intestinal transcriptome", Toxins, 10, pp.199~ (2018)[DOI]
  62. Weaver AC, "The use of feed additives to reduce the effects of aflatoxin and deoxynivalenol on pig growth, organ health and immune status during chronic exposure", Toxins, 5, pp.1261~1281 (2013)[DOI]
  63. Liao Y, "Deoxynivalenol, gut microbiota and immunotoxicity : a potential approach?", Food Chem Toxicol, 112, pp.342~354 (2018)[DOI]
  64. Alassane-Kpembi I, "Co-exposure to low doses of the food contaminants deoxynivalenol and nivalenol has a synergistic inflammatory effect on intestinal explants", Arch Toxicol, 91, pp.2677~2687 (2017)[DOI]
  65. Wu W, "Effects of oral exposure to naturally-occurring and synthetic deoxynivalenol congeners on proinflammatory cytokine and chemokine mRNA expression in the mouse", Toxicol Appl Pharmacol, 278, pp.107~115 (2014)[DOI]
  66. Zhang H, "Deoxynivalenol induces inflammation in IPEC-J2 cells by activating P38 Mapk and Erk1", 2, 2020, pp.12, 180~
  67. Kang R, "Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production", Environ Pollut, 251, pp.689~698 (2019)[DOI]
  68. Nagashima H, "Differences in the toxicities of trichothecene mycotoxins, deoxynivalenol and nivalenol, in cultured cells", Jpn Agric Res Q, 48, pp.393~397 (2014)[DOI]
  69. Wang S, "Potential link between gut microbiota and deoxynivalenol-induced feed refusal in weaned piglets", J Agric Food Chem, 67, pp.4976~4986 (2019)[DOI]
  70. Xu X, "Comparative transcriptome analysis reveals the protective mechanism of glycyrrhinic acid for deoxynivalenol-induced inflammation and apoptosis in IPEC-J2 cells", Oxid Med Cell Longev, 2020, pp.5974157~ (2020)[DOI]
  71. Mutamed Ayyash, "Bioactive Properties of Novel Probiotic Lactococcus lactis Fermented Camel Sausages: Cytotoxicity, Angiotensin Converting Enzyme Inhibition, Antioxidant Capacity, and Antidiabetic Activity", 한국축산식품학회지, 40(2), pp.155~171 (2020), 한국축산식품학회[DOI]
  72. 이예원, "Probiotics-Mediated Bioconversion and Periodontitis", 한국축산식품학회지, 41(6), pp.905~922 (2021), 한국축산식품학회[DOI]
  73. Vogt SL, "Gut microbiota-mediated protection against diarrheal infections", J Travel Med, 24, pp.S39~43 (2017)[DOI]
  74. Goyarts T, "Bioavailability of the Fusarium toxin deoxynivalenol(DON)from naturally contaminated wheat for the pig", Toxicol Lett, 163, pp.171~182 (2006)[DOI]
  75. Waché YJ, "Impact of deoxynivalenol on the intestinal microflora of pigs", Int J Mol Sci, 10, pp.1~17 (2009)[DOI]
  76. Wang S, "Sodium butyrate protects the intestinal barrier by modulating intestinal host defense peptide expression and gut microbiota after a challenge with deoxynivalenol in weaned piglets", J Agric Food Chem, 68, pp.4515~4527 (2020)[DOI]
  77. Reddy KE, "Colon microbiome of pigs fed diet contaminated with commercial purified deoxynivalenol and zearalenone", Toxins, 10, pp.347~ (2018)[DOI]
  78. Reddy Kondreddy Eswar, "Effect of commercially purified deoxynivalenol and zearalenone mycotoxins on microbial diversity of pig cecum contents", Animal Bioscience, 34(2), pp.243~255 (2021), 아세아·태평양축산학회[DOI]
  79. Maresca M, "Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium : stimulation of interleukin-8 secretion, potentiation of interleukin-1β effect and increase in the transepithelial passage of commensal bacteria", Toxicol Appl Pharmacol, 228, pp.84~92 (2008)[DOI]
  80. Yang X, "Gut microbiota mediates the protective role of Lactobacillus plantarum in ameliorating deoxynivalenol-induced apoptosis and intestinal inflammation of broiler chickens", Poult Sci, 99, pp.2395~2406 (2020)[DOI]
  81. Wang S, "Isolation and characterization of a deoxynivalenol-degrading bacterium Bacillus licheniformis YB9 with the capability of modulating intestinal microbial flora of mice", Toxins, 12, pp.184~ (2020)[DOI]
  82. Parada Venegas D, "Short chain fatty acids(SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases", Front Immunol, 10, pp.277~ (2019)[DOI]
  83. Scheppach W, "Effects of short chain fatty acids on gut morphology and function", Gut, 35, pp.S35~S38 (1994)[DOI]
  84. Qiu Y, "Dietary resveratrol attenuation of intestinal inflammation and oxidative damage is linked to the alteration of gut microbiota and butyrate in piglets challenged with deoxynivalenol", J Anim Sci Biotechnol, 12, pp.71~ (2021)[DOI]

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