厚朴麻黃湯이 ovalbumin으로 유도된 천식 모델 생쥐에 미치는 영향
Effects of Hubakmawhang-tang on Asthma Model Mice Induced by Ovalbumin
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참고문헌
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초록
Hubakmawhang-tang (HMT), listed in Geumgweyoryak, is an oriental medicine used for the symptoms of asthma, such as cough and dyspnea. In this study, we investigated the HMT effects on ovalbumin-induced asthmatic in mice. We examined weight changes, airway hyperresponsiveness, histopathological abnormalities, immune cell infiltrations, immunoglobulin and inflammatory cytokine levels, and spleen body weight ratios in asthmatic mice. HMT inhibited airway hyperresponsiveness, immune cell infiltration, and airway remodeling and caused a significant lowering of serum IgE and IgG1 levels. The asthmatic mice had elevated IL-4 levels in lung tissue and this elevation was effectively prevented by HMT. HMT did not cause changes in body weight or in the spleen body weight ratio. Therefore, HMT might have an anti-asthmatic effect in the ovalbumin-induced mouse model.
Abstract
Hubakmawhang-tang (HMT), listed in Geumgweyoryak, is an oriental medicine used for the symptoms of asthma, such as cough and dyspnea. In this study, we investigated the HMT effects on ovalbumin-induced asthmatic in mice. We examined weight changes, airway hyperresponsiveness, histopathological abnormalities, immune cell infiltrations, immunoglobulin and inflammatory cytokine levels, and spleen body weight ratios in asthmatic mice. HMT inhibited airway hyperresponsiveness, immune cell infiltration, and airway remodeling and caused a significant lowering of serum IgE and IgG1 levels. The asthmatic mice had elevated IL-4 levels in lung tissue and this elevation was effectively prevented by HMT. HMT did not cause changes in body weight or in the spleen body weight ratio. Therefore, HMT might have an anti-asthmatic effect in the ovalbumin-induced mouse model.
참고문헌 (43)
- Yu SH, "Manual of Pulmonology, 1st edition", pp.116~ (2012), Daehan medical publishing
- 김세훈, "천식의 기도 염증과 개형 발생에서 기도상피세포의 역할", Allergy Asthma & Respiratory Disease, 4(2), pp.82~90 (2016), 대한 소아알레르기 호흡기학회[DOI]
- Davey P, "Medicine at a glance, 2nd edition", pp.189~190 (2010), E public
- "Global Strategy for Asthma Management and Prevention (Uptated 2017)"[URL]
- "Asthma fact sheet Updated April 2017"[URL]
- Department of Pulmonary Internal Medicine, College of Korean Medicine, "Pulmonary Internal Medicine, 1st edition", pp.102~ (2011), Nado Publishing
- Yang SS, "Geumgweyoryak, 1st edition", pp.189~190 (1994), Aulos Publishing
- Lee KY, "Bigeub Cheongeumyobang Gyoyeog, 1st edition", pp.297~ (1997), People's medical publishing house
- Choi JB, "Medicine of Internal organs, 1st edition", pp.75~ (1995), Gyungsan University Publishing
- 서범수, "결명자 추출물의 난알부민 감작으로 천식이 유발된 마우스에서의 개선 효과", 대한본초학회지, 30(1), pp.25~32 (2015), 대한본초학회
- 강석용, "곽향(藿香)의 난알부민으로 유도된 천식 마우스에서의 천식개선 효능연구", 대한본초학회지, 30(3), pp.1~12 (2015), 대한본초학회
- 조소현, "甘草麻黃湯 추출물의 배합 비율에 따른 투여가 Ovalbumin으로 유발된 천식 생쥐에 미치는 영향", 한방안이비인후피부과학회지, 28(4), pp.74~91 (2015), 대한한방안이비인후피부과학회
- Jung JK, "Effects of modified-Okbyungpoongsan in allergic asthma" (2017)
- 정동환, "반하가 난황으로 유발된 생쥐의 알레르기성 천식에 미치는 영향", 한방안이비인후피부과학회지, 21(1), pp.38~54 (2008), 대한한방안이비인후피부과학회
- 조은희, "마황 추출물 투여가 Ovalbumin으로 유발된 마우스 알레르기성 천식에 미치는 영향", 한방안이비인후피부과학회지, 27(3), pp.84~95 (2014), 대한한방안이비인후피부과학회
- 주창엽, "杏仁이 천식관련 chemokine 분비와 호산구 chemotaxis에 미치는 영향", 대한한방내과학회지, 27(1), pp.208~220 (2006), 대한한방내과학회
- 조성은, "세신 전탕액 경구투여가 천식 억제 및 면역조절에 미치는 영향", Journal of Acupuncture Research, 33(1), pp.23~36 (2016), 대한침구의학회
- 정진용, "염증이 유발된 인간기관지상피세포에서 오미자가 Microarray를 이용한 유전자 발현 분석에 미치는 영향", 대한한방내과학회지, 29(3), pp.543~553 (2008), 대한한방내과학회
- Park YS, "Analysis of Pharmacology in Korean Medicine, 2nd edition", pp.1344~1347 (2002), Academy Publishing
- Seo JU, "Hubakmahwang-Tang and Its Component, Magnolol Enhanced the Anti-Cancer Activity in Human Lung Cancer Cells" (2010)
- 김진숙, "마우스 만성천식모델에서 경구면역관용 유도에 의한 알레르기 염증의 예방효과", Tuberculosis and Respiratory Diseases, 57(5), pp.425~433 (2004), 대한결핵및호흡기학회
- Kim HW, "Combination treatment with Socheongryong-Tang, a herbal medicine, and prednisolone reduces inflammation and hyperresponsiveness of the airway in asthmatic mice : via regulation of Th2 skewing cytokines and antigen specific antibody production" (2007)
- Hamelmann E, "Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography", Am J Respir Crit Care Med, 156(3), pp.766~775 (1997)[DOI]
- 김경묵, "기관지천식 치료의 최신 지견", 대한내과학회지, 78(6), pp.697~702 (2010), 대한내과학회
- Oh G, "Book 1 of Uijonggeumgam, 1st edition", pp.487~ (1991), Daesung Publishing
- Kim DH, "Oriental pharmacy. 4th edition", pp.229~ (2015), Shinilbooks
- Kim H, "Antiasthmatic effects of schizandrae fructus extract in mice with asthma", Pharmacogn Mag, 10(1), pp.80~85 (2014)[DOI]
- Smith JG Jr, "Corticosteroidinduced cutaneous atrophy and telangiectasia: experimental production associated with weight loss in rats", Arch Dermatol, 112(8), pp.1115~1117 (1976)[DOI]
- Hargreave FE, "Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance", J Allergy Clin Immunol, 68(5), pp.347~355 (1981)[DOI]
- 김건하, "천식 환아에서 메타콜린 기관지 과민성의 추적 관찰", Allergy Asthma & Respiratory Disease, 17(3), pp.196~205 (2007), 대한 소아알레르기 호흡기학회
- 정희진, "배 에탄올 추출물이 난황에 의하여 유발된 생쥐의 천식에 미치는 영향", 대한본초학회지, 27(1), pp.11~16 (2012), 대한본초학회
- 김영일, "메타콜린 상부기도과민성과 상부기도폐쇄의 원인에 관한 연구", 천식 및 알레르기, 30(1), pp.21~29 (2010), 대한천식알레르기학회
- Bullone M, "Asthma of horses and men: how can equine heaves help us better understand human asthma immunopathology and its functional consequences?", Mol Immunol, 66(1), pp.97~105 (2015)[DOI]
- Kindt T, "Kuby immunology, 6th edition", pp.289~291 (2006), W. H. Freeman and Company
- Balzar S, "IgE expression pattern in lung: Relation to systemic IgE and asthma phenotypes", J Allergy Clin Immunol, 119(4), pp.855~862 (2007)[DOI]
- Chakir J, "Airway remodelingassociated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression", J Allergy Clin Immunol, 111(6), pp.1293~1298 (2003)[DOI]
- Wen MC, "Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma", J Allergy Clin Immunol, 116(3), pp.517~524 (2005)[DOI]
- Lynch EL, "Immuno-modulatory cytokines in asthmatic inflammation", Cytokine Growth Factor Rev, 14(6), pp.489~502 (2003)[DOI]
- Medoff BD, "IFN-gammainducible protein 10(CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma", J Immunol, 168(10), pp.5278~5286 (2002)[DOI]
- Wardlaw AJ, "New insights into the relationship between airway inflammation and asthma", Clin Sci(Lond), 103(2), pp.201~211 (2002)
- Corry DB, "Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity", J Exp Med, 183(1), pp.109~117 (1996)[DOI]
- Isselbacher KJ, "Principles of Internal Medicine, 11th edition", pp.1757~1777 (1987), McGraw-Hill Education
- Lee HJ, "Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice", Mol Med Rep, 12(2), pp.2135~2139 (2015)[DOI]
