알레르기 질환 유무와 소화 불편 증상의 관련성에 대한 연구: 성향점수 매칭을 활용
A Study on the Relationship between Allergic Diseases and Gastrointestinal Discomfort Symptoms: Using Propensity Score Matching
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: This study aimed to investigate the relationship between allergic diseases and digestive discomfort symptoms using a dataset for the traditional Korean medicine examination. Methods: The study included 389 subjects in the allergy group, diagnosed with allergic diseases by either a Korean medicine doctor or modern medical doctor, and there were 4,160 subjects in the control group. Propensity score matching was used to control the factors affecting the allergic disease and digestive discomfort symptoms. These factors included age, sex, medication history, obesity, smoking status, alcohol consumption, meal frequency, meal quantity, eating speed, sleep quality, stress level, and physical activity, matched at a ratio of 1:1. Logistic regression was used to estimate the adjusted odds ratio of digestive discomfort symptoms in the allergy group compared to the control group. Results: Compared to the control group, subjects in the allergy group had a significantly higher risk of having abdominal distention 1.62 times (OR=1.62, 95% CI: 1.13-2.32, p-value=0.008) and postprandial fatigue 1.41 times (OR=1.41, 95% CI: 1.02-1.95, p-value=0.037). Conclusion: The study suggests that allergic diseases were associated with certain digestive discomfort symptoms. The findings of this study can serve as a basis for managing both allergic diseases and digestive discomfort symptoms together.
Abstract
Objectives: This study aimed to investigate the relationship between allergic diseases and digestive discomfort symptoms using a dataset for the traditional Korean medicine examination. Methods: The study included 389 subjects in the allergy group, diagnosed with allergic diseases by either a Korean medicine doctor or modern medical doctor, and there were 4,160 subjects in the control group. Propensity score matching was used to control the factors affecting the allergic disease and digestive discomfort symptoms. These factors included age, sex, medication history, obesity, smoking status, alcohol consumption, meal frequency, meal quantity, eating speed, sleep quality, stress level, and physical activity, matched at a ratio of 1:1. Logistic regression was used to estimate the adjusted odds ratio of digestive discomfort symptoms in the allergy group compared to the control group. Results: Compared to the control group, subjects in the allergy group had a significantly higher risk of having abdominal distention 1.62 times (OR=1.62, 95% CI: 1.13-2.32, p-value=0.008) and postprandial fatigue 1.41 times (OR=1.41, 95% CI: 1.02-1.95, p-value=0.037). Conclusion: The study suggests that allergic diseases were associated with certain digestive discomfort symptoms. The findings of this study can serve as a basis for managing both allergic diseases and digestive discomfort symptoms together.
참고문헌 (26)
- Pinart M, "Systematic Review on the Definition of Allergic Diseases in Children : The MeDALL Study", Int Arch Allergy Immunol, 168(2), pp.110~121 (2015)
- Baiardini I, "Allergic diseases and their impact on quality of life", Ann Allergy Asthma Immunol, 97(4), pp.419~428 (2006)
- Jang BH, "Current status of allergic rhinitis patients in Korean Medicine hospitals-Exploratory study based on electronic medical records of 3 hospitals", J Korean Med Ophthalmol Otolaryngol Dermatol, 27(1), pp.117~129 (2014)
- Kim YJ, "A Review of Korean Medical Pathogenesis, Pattern Identification, Treatment Principle and Herbal Medicines for Allergic Conjunctivitis in Pediatric Patients", J Pediatr Korean Med, 35(2), pp.21~36 (2021)
- Korea Institute of Oriental Medicine, "Atopic Dermatitis Korean Medicine Clinical Practice Guideline", pp.37~50 (2015), Elsevier Korea
- Gil YS, "Review of Literatures on Allergic Asthma", J Korean Med, 11(1), pp.39~70 (1990)
- Im GM, "Oriental Medical Approach on the Allergic Disease", J Physiol & Pathol Korean Med, 16(5), pp.831~839 (2002)
- Noh HM, "The Study about the Comparison of Korean-Western Medicine on Atopic Dermatitis and Food Allergy", J Korean Med Ophthalmol Otolaryngol Dermatol, 30(2), pp.86~99 (2017)
- Yamamoto Y, "Multimorbidity of Allergic Diseases Is Associated With Functional Gastrointestinal Disorders in a Young Japanese Population", J Neurogastroenterol Motil, 30(2), pp.229~235 (2024)
- Jones MP, "The overlap of atopy and functional gastrointestinal disorders among 23, 471 patients in primary care", Aliment Pharmacol Ther, 40(4), pp.382~391 (2014)
- Stanghellini V, "Functional Dyspepsia and Irritable Bowel Syndrome : Beyond Rome IV", Dig Dis, 35(Suppl 1), pp.14~17 (2017)
- Ozdemir C, "Lifestyle Changes and Industrialization in the Development of Allergic Diseases", Curr Allergy Asthma Rep, 24(7), pp.331~345 (2024)
- Talley NJ, "What Causes Functional Gastrointestinal Disorders? A Proposed Disease Model", Am J Gastroenterol, 115(1), pp.41~48 (2020)
- Kim SY, "Establishment of a Dataset for the Traditional Korean Medicine Examination in Healthy Adults", Healthcare(Basel), 12(9), pp.918~ (2024)
- Faulkner S, "Use of the Pittsburgh Sleep Quality Index in People With Schizophrenia Spectrum Disorders : A Mixed Methods Study", Front Psychiatry, 10, pp.284~ (2019)
- Cohen S, "A global measure of perceived stress", J Health Soc Behav, 24(4), pp.385~396 (1983)
- Polinski KJ, "Perceived Stress and Inflammatory Arthritis : A Prospective Investigation in the Studies of the Etiologies of Rheumatoid Arthritis Cohort", Arthritis Care Res(Hoboken), 72(12), pp.1766~1771 (2020)
- Lee JH, "The Reliability and Validity Studies of the Korean Version of the Perceived Stress Scale", Korean J Psychosom Med, 20(2), pp.127~134 (2012)
- Oh JY, "Validity and Reliability of Korean Version of International Physical Activity Questionnaire(IPAQ)Short Form", J Korean Acad Fam Med, 28(7), pp.532~541 (2007)
- Kim JE, "Research of Pattern Identification and Outcome Measurement in Allergic Rhinitis", J Pediatr Korean Med, 30(1), pp.32~39 (2016)
- Kim MH, "Developing Pattern Identification Questionnaire of Allergic Rhinitis", J Korean Med Ophthalmol Otolaryngol Dermatol, 30(2), pp.112~125 (2017)
- Walker MM, "The role of eosinophils and mast cells in intestinal functional disease", Curr Gastroenterol Rep, 13(4), pp.323~330 (2011)
- Walker MM, "Duodenal eosinophilia and early satiety in functional dyspepsia : confirmation of a positive association in an Australian cohort", J Gastroenterol Hepatol, 29(3), pp.474~479 (2014)
- Akay HK, "The relationship between bifidobacteria and allergic asthma and", or allergic dermatitis : a prospective study of 0-3 years-old children in Turkey, 2014, pp.28, 98~103
- Vieira EL, "Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis", J Nut Biochem, 23(5), pp.430~436 (2012)
- Ceulemans M, "Immune Activation in Functional Dyspepsia : Bystander Becoming the Suspect", Front Neurosci, 16, pp.831761~ (2022)