헬리코박터 파일로리 연관 위궤양의 감초사심탕(甘草瀉心湯) 치료에 대한 임상 연구 동향 고찰
A Review of Clinical Research on Gamchosasim-tang for Helicobacter Pylori Associated Gastric Ulcer
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives: The purpose of this study was to investigate clinical research trends regarding the efficacy of Gamchosasim-tang on Helicobacter pylori-associated gastric ulcer. Methods: Studies were searched on Pubmed, CNKI, and domestic databases (OASIS, ScienceON, RISS, KISS, and Kmbase) using keywords such as “helicobacter”, “h. pylori”, “ulcer”, and “Gancao Xiexin.” Data on the publication year, characteristics of patients, diagnosis methods, interventions, outcome measures, and results were extracted. The quality of each study was assessed using a risk-of-bias tool. Results: In total, eight studies were selected. All were randomized-controlled trials. Gamchosasim-tang and quadruple therapy were co-administered for the treatment group in most of the studies. A combination of Gamchosasim-tang and eradication therapy was effective in improving disease-associated symptoms and lowering recurrence rate. No obvious side effects were observed in any of the studies. Conclusion: Gamchosasim-tang can be a safe and effective treatment method for helicobacter pylori-associated gastric ulcer, so it can be used in clinical practice.
Abstract
Objectives: The purpose of this study was to investigate clinical research trends regarding the efficacy of Gamchosasim-tang on Helicobacter pylori-associated gastric ulcer. Methods: Studies were searched on Pubmed, CNKI, and domestic databases (OASIS, ScienceON, RISS, KISS, and Kmbase) using keywords such as “helicobacter”, “h. pylori”, “ulcer”, and “Gancao Xiexin.” Data on the publication year, characteristics of patients, diagnosis methods, interventions, outcome measures, and results were extracted. The quality of each study was assessed using a risk-of-bias tool. Results: In total, eight studies were selected. All were randomized-controlled trials. Gamchosasim-tang and quadruple therapy were co-administered for the treatment group in most of the studies. A combination of Gamchosasim-tang and eradication therapy was effective in improving disease-associated symptoms and lowering recurrence rate. No obvious side effects were observed in any of the studies. Conclusion: Gamchosasim-tang can be a safe and effective treatment method for helicobacter pylori-associated gastric ulcer, so it can be used in clinical practice.
참고문헌 (49)
- Park CH, "Helicobacter Pylori Eradication Therapy and Gastric Cancer Prevention", Korean J Helicobacter Up Gastrointest Res, 21(4), pp.267~274 (2021)
- Kim BJ, "Epidemiology and Pathophysiology of Helicobacter Pylori Infections in Korea", Korean J Med, 89(2), pp.133~141 (2015)
- Lanas A, "Peptic Ulcer Disease", Lancet, 390(10094), pp.613~624 (2017)
- Yeo SH, "Peptic Ulcer Disease Associated with Helicobacter Pylori Infection", Korean J Gastroenterol, 67(6), pp.289~299 (2016)
- Crowe SE, "Helicobacter Pylori Infection", N Engl J Med, 380(12), pp.1158~1165 (2019)
- Lim SH, "Prevalence and Risk Factors of Helicobacter Pylori Infection in Korea : Nationwide Multicenter Study over 13Years", BMC Gastroenterol, 13(104), pp.104~ (2013)
- Jung J, "Inhibitory Activities of Palmatine from Coptis Chinensis Against Helicobactor Pylori and Gastric Damage", Toxicol Res, 30(1), pp.45~48 (2014)
- 李文红, "黄芪建中汤治疗幽门螺旋杆菌阳性胃溃疡35例", 光明中医, 34(19), pp.2988~2990 (2019)
- 王蓓蓓, "黄芪建中汤加减联合四联疗法对Hp 阳性胃溃疡患者Hp清除率及复发率的影响", 医学信息, 35(20), pp.145~147 (2022)
- 周雅新, "甘草泻心汤治疗幽门螺杆菌相关性胃溃疡临的床研究", pp.2014
- Yang DS, "A Case of Suggested Behcet’s Disease Patient Treated by Gamchosasim-Tang", J Orient Obstet Gynecol, 22(4), pp.187~193 (2009)
- Kim KL, "A Case Report of Gastrointestinal Symptoms in Gastric Ulcer Treated with Gamchosasim-Tang", J Intern Korean Med, 40(5), pp.878~887 (2019)
- Kim YK, "A Study of the Effectiveness of Hwanggeum-Tang and Gamchosasim-Tang in the Mice Model of Inflammatory Bowel Disease", J Intern Korean Med, 42(3), pp.351~374 (2021)
- 刘少康, "甘草泻心汤联合泮托拉唑四联疗法治疗幽门螺杆菌相关性胃溃疡临床疗分析", 社区中医药, 35(31), pp.97~98 (2019)
- 苏国春, "甘草泻心汤联合泮托拉唑四联疗法治疗幽门螺杆菌相关性胃溃疡临床疗效观察", 四川中医, 35(4), pp.93~94 (2017)
- 吕恩基, "甘草泻心汤加减治疗幽门螺杆菌相关性胃溃疡80例的临床观察", 哈尔滨医药, 38(6), pp.570~571 (2018)
- 徐兴龙, "泮托拉唑联合甘草泻心汤治疗幽门螺杆菌相关性胃溃疡疗效观察", 西部中医药, 32(9), pp.93~95 (2019)
- 李春颖, "甘草泻心汤加减治疗幽门螺杆菌相关性胃溃疡临床研究", 现代医药卫生, 36(5), pp.734~736 (2020)
- 王增增, "甘草泻心汤加减治疗幽门螺杆菌相关性胃溃疡临床观察", 实用中医药杂志, 38(8), pp.1305~1307 (2022)
- 谷圣青, "甘草泻心汤联合四联疗法治疗幽门螺杆菌相关性胃溃疡的临床研究", 中国农村卫生, 8(110), pp.43~44 (2017)
- Gianmichele M, "Prevalence and Risk Factors of Helicobacter Pylori-Negative Peptic Ulcer : A Multicenter Study", J Clin Gastroenterol, 31(1), pp.42~47 (2000)
- Malfertheiner P, "The Intriguing Relationship of Helicobacter Pylori Infection and Acid Secretion in Peptic Ulcer Disease and Gastric Cancer", Dig Dis, 29(5), pp.459~464 (2011)
- Sung JK, "Diagnosis and Treatment of Helicobacter Pylori Infection", Korean J Med, 89(2), pp.149~156 (2015)
- Gong EJ, "Meta-Analysis of First-Line Triple Therapy for Helicobacter Pylori Eradication in Korea : Is It Time to Change?", J Korean Med Sci, 29(5), pp.704~713 (2014)
- Kim SG, "Guidelines for the Diagnosis and Treatment of Helicobacter Pylori Infection in Korea, 2013 Revised Edition", J Gastroenterol Hepatol, 29(7), pp.1371~1386 (2014)
- Malfertheiner P, "Management of Helicobacter Pylori Infection : The Maastricht VI", Florence Consensus Report, 2022, pp.71, 1724~1762
- Park JY, "New Helicobacter Pylori Eradication Therapies", Korean J Gastroenterol, 72(5), pp.237~244 (2018)
- Kwon YH, "The Current Strategy of Helicobacter Pylori Eradication", Korean J Med, 96(1), pp.13~21 (2021)
- Park GH, "Three Case Reports of Peptic Ulcer Patients Treated with Banhasasim-Tang", Korean J Orient Physiol Pathol, 26(6), pp.940~946 (2012)
- Kim MC, "One Case Report of Peptic Ulcer Patient Who Was Administered by Anjungsan", Korean J Orient Med Prescr, 19(1), pp.253~261 (2011)
- Lee YR, "The Effect of Opae-San for Peptic Ulcer Disease : A Systematic Review and Meta-Analysis", J Intern Korean Med, 39(6), pp.1136~1149 (2018)
- Jeon CM, "Effect of the Methanol Extract of Dansameum on the Ammonia-Induced Peptic Ulcer in Rats", Korean J Orient Intern Med, 21(4), pp.597~604 (2000)
- Lee IH, "The Efficiency of Dohwa-Tang on Peptic Ulcer of Rat and Transportability in the Large Intestine of Mouse", Korean J Orient Intern Med, 22(2), pp.207~213 (2001)
- 廖智强, "半夏泻心汤加味治疗对Hp感染性胃溃疡患者Hp清除率及溃疡愈合情况的影响", 基层医学论坛, 25(14), pp.2045~2046 (2021)
- 苏民党, "半夏泻心汤治疗消化性溃疡的应用分析", Guid China Med, 21(12), pp.110~113 (2023)
- 葛国艳, "半夏泻心汤加减联合西药四联疗法治疗Hp感染胃溃疡的疗效", 基层医学论坛, 25(34), pp.4985~4987 (2021)
- 武艳丽, "加味黄连解毒汤联合雷贝拉唑对胃溃疡Hp 感染患者血清CＲP, IL-6水平的影响", 医学理论与实践, 34(15), pp.2608~2609 (2021)
- 姚利锋, "加味黄连解毒汤联合西药治疗幽门螺杆菌感染性胃溃疡临床研究", 新中医, 53(6), pp.21~24 (2021)
- 唐金明, "理气和胃汤治疗幽门螺杆菌阳性胃溃疡患者的经验总结", 临床医药文献电子杂志, 6(67), pp.157~ (2019)
- 徐超男, "理气和胃汤联合三联疗法在幽门螺杆菌感染胃溃疡中的临床疗效分析", 甘肃科技, 37(1), pp.122~125 (2021)
- 王保健, "清中汤加味配合西药治疗幽门螺杆菌相关性胃溃疡疗效评价", 四川中医, 36(8), pp.80~82 (2018)
- 王思霖, "半夏泻心汤联合三联疗法治疗消化性溃疡的系统评价", 中医临床研究, 14(35), pp.60~63 (2022)
- 许文娟, "半夏泻心汤联合三联疗法治疗幽门螺旋杆菌相关性胃炎的Meta分析", 中国民族民间医药, 29(24), pp.75~79 (2020)
- Committee H pharmacology compilation, "Herbal Pharmacology", pp.136~167 (2015), Shinilbooks
- Rahnama M, "The Healing Effect of Licorice(Glycyrrhiza Glabra)on Helicobacter Pylori Infected Peptic Ulcers", J Res Med Sci, (June), pp.6532~533 (2013)
- Jalilzadeh-Amin G, "Antiulcer Properties of Glycyrrhiza Glabra L. Extract on Experimental Models of Gastric Ulcer in Mice", Iran J Pharm Res, 14(4), pp.1163~1170 (2015)
- Goorani S, "The Aqueous Extract of Glycyrrhiza Glabra Effectively Prevents Induced Gastroduodenal Ulcers : Experimental Study on Wistar Rats", Comp Clin Path, 28(2), pp.339~347 (2019)
- Panara K, "A Review on Phytochemical and Pharmacological Properties of Citrus Medica Linn", Int J Pharm Biol Arch, 3(6), pp.1292~1297 (2012)
- Nagaraju B, "Antiulcer Activity of Aqueous Extract of Citrus Medica Linn. Fruit Against Ethanol-Induced Ulcer in Rats", Adv Biol Res(Rennes), 6(1), pp.24~29 (2012)