본문 바로가기
KERD
논문KCI 등재

Fermented Laminaria japonica improves working memory and antioxidant defense mechanism in healthy adults: a randomized, double-blind, and placebo-controlled clinical study

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류수산학

초록

A randomized, double-blind, and placebo-controlled clinical study was used to determine the cognitive functions related to working memory (WM) and antioxidant properties of fermented Laminaria japonica (FLJ) on healthy volunteers. Eighty participants were divided into a placebo group (n = 40) and FLJ group (n = 40) that received FLJ (1.5 g/day) for 6 weeks. Memory-related blood indices (brain-derived neurotrophic factor, BDNF; angiotensin-converting enzyme; human growth hormone, HGH; insulin-like growth factor-1, IGF-1) and antioxidant function-related indices (catalase, CAT; malondialdehyde, MDA; 8-oxo-2’-deoxyguanosine, 8-oxo-dG; thiobarbituric acid reactive substances, TBARS) were determined before and after the trial. In addition, standardized cognitive tests were conducted using the Cambridge Neuropsychological Test Automated Batteries. Furthermore, the Korean Wechsler Adult Intelligence Scale (K-WAIS)-IV, and the Korean version of the Montreal Cognitive Assessment (Mo- CA-K) were used to assess the pre and post intake changes on WM-related properties. According to the results, FLJ significantly increased the level of CAT, BDNF, HGH, and IGF-1. FLJ reduced the level of TBARS, MDA, and 8-oxo-dG in serum. Furthermore, FLJ improved physical activities related to cognitive functions such as K-WAIS-IV, MoCA-K, Paired Associates Learning, and Spatial Working Memory compared to the placebo group. Our results suggest that FLJ is a potential candidate to develop functional materials reflecting its capability to induce antioxidant mechanisms together with WM-related indices.

Abstract

A randomized, double-blind, and placebo-controlled clinical study was used to determine the cognitive functions related to working memory (WM) and antioxidant properties of fermented Laminaria japonica (FLJ) on healthy volunteers. Eighty participants were divided into a placebo group (n = 40) and FLJ group (n = 40) that received FLJ (1.5 g/day) for 6 weeks. Memory-related blood indices (brain-derived neurotrophic factor, BDNF; angiotensin-converting enzyme; human growth hormone, HGH; insulin-like growth factor-1, IGF-1) and antioxidant function-related indices (catalase, CAT; malondialdehyde, MDA; 8-oxo-2’-deoxyguanosine, 8-oxo-dG; thiobarbituric acid reactive substances, TBARS) were determined before and after the trial. In addition, standardized cognitive tests were conducted using the Cambridge Neuropsychological Test Automated Batteries. Furthermore, the Korean Wechsler Adult Intelligence Scale (K-WAIS)-IV, and the Korean version of the Montreal Cognitive Assessment (Mo- CA-K) were used to assess the pre and post intake changes on WM-related properties. According to the results, FLJ significantly increased the level of CAT, BDNF, HGH, and IGF-1. FLJ reduced the level of TBARS, MDA, and 8-oxo-dG in serum. Furthermore, FLJ improved physical activities related to cognitive functions such as K-WAIS-IV, MoCA-K, Paired Associates Learning, and Spatial Working Memory compared to the placebo group. Our results suggest that FLJ is a potential candidate to develop functional materials reflecting its capability to induce antioxidant mechanisms together with WM-related indices.

참고문헌 (46)

  1. Alloway TP, "Investigating the predictive roles of working memory and IQ in academic attainment", J Exp Child Psychol, 106, pp.20~29 (2010)
  2. Asanka Sanjeewa KK, "Edible brown seaweeds : a review", J Food Bioact, 2, pp.37~50 (2018)
  3. Asanka Sanjeewa KK, "Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds : a review", J Photochem Photobiol B Biol, 162, pp.100~105 (2016)
  4. Asanka Sanjeewa KK, "Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications : a review", J Appl Phycol, 29, pp.3109~3119 (2017)
  5. Baddeley A, "Working memory", Science, 255, pp.556~559 (1992)
  6. Barnett JH, "The paired associates learning(PAL)test : 30 years of CANTAB translational neuroscience from laboratory to bedside in dementia research", Curr Top Behav Neurosci, 28, pp.449~474 (2016)
  7. 차재영, "GABA-enriched Fermented Laminaria japonica Protects against Alcoholic Hepatotoxicity in Sprague-Dawley Rats", Fisheries and Aquatic Sciences, 14(2), pp.79~88 (2011), 한국수산과학회
  8. Chen YC, "Alleviative effect of fucoxanthin-containing extract from brown seaweed Laminaria japonica on renal tubular cell apoptosis through upregulating Na+", H+ exchanger NHE1 in chronic kidney disease mice, 2018, pp.224, 391~399
  9. Choi YS, "Effects of Laminaria japonica on the physico-chemical and sensory characteristics of reduced-fat pork patties", Meat Sci, 91, pp.1~7 (2012)
  10. Cirulli F, "Intrahippocampal administration of BDNF in adult rats affects shortterm behavioral plasticity in the Morris water maze and performance in the elevated plus-maze", Hippocampus, 14, pp.802~807 (2004)
  11. Cowan N, "The many faces of working memory and short-term storage", Psychon Bull Rev, 24, pp.1158~1170 (2017)
  12. Fang Q, "Immunomodulatory activity on macrophage of a purified polysaccharide extracted from Laminaria japonica", Carbohydr Polym, 134, pp.66~73 (2015)
  13. Head E, "Oxidative damage and cognitive dysfunction : antioxidant treatments to promote healthy brain aging", Neurochem Res, 34, pp.670~678 (2009)
  14. Kadam SU, "Application of novel extraction technologies for bioactives from marine algae", J Agric Food Chem, 61, pp.4667~4675 (2013)
  15. Kang MC, "Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db", db mouse model, 2013, pp.53, 294~298
  16. Kang SY, "Anti-diabetic effects and anti-inflammatory effects of Laminaria japonica and Hizikia fusiforme in skeletal muscle : in vitro and in vivo model", Nutrients, 10, pp.491~ (2018)
  17. Kang YM, "Antioxidant effects of fermented sea tangle(Laminaria japonica)by Lactobacillus brevis BJ20 in individuals with high level of γ-GT : a randomized, double-blind, and placebo-controlled clinical study", Food Chem Toxicol, 50, pp.1166~1169 (2012)
  18. Kaser M, "Modafinil improves episodic memory and working memory cognition in patients with remitted depression : a double-blind, randomized, placebo-controlled study", Biol Psychiatry Cogn Neurosci Neuroimaging, 2, pp.115~122 (2017)
  19. Khan Z, "Oxidative stress-related biomarkers in Parkinson’s disease : a systematic review and meta-analysis", Iran J Neurol, 17, pp.137~144 (2018)
  20. Kim SK, "Marine medicinal foods: implications and applications, macro and microalgae", pp.85~96 (2011), Academic Press
  21. Lee A, "Age-related decline in associative learning in healthy Chinese adults", PLOS ONE, 8, pp.e80648~ (2013)
  22. Lee BJ, "Antioxidant activity and γ-aminobutyric acid(GABA)content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods", Food Chem, 122, pp.271~276 (2010)
  23. Liguori I, "Oxidative stress, aging, and diseases", Clin Interv Aging, 13, pp.757~772 (2018)
  24. Lin HTV, "Enhanced anti-inflammatory activity of brown seaweed Laminaria japonica by fermentation using Bacillus subtilis", Process Biochem, 51, pp.1945~1953 (2016)
  25. Lommatzsch M, "The impact of age, weight and gender on BDNF levels in human platelets and plasma", Neurobiol Aging, 26, pp.115~123 (2005)
  26. Lu J, "The antioxidant capacity of polysaccharide from Laminaria japonica by citric acid extraction", Int J Food Sci Technol, 48, pp.1352~1358 (2013)
  27. Ma L, "Working memory test battery for young adults : computerized working memory assessment", PLOS ONE, 12, pp.e0175047~ (2017)
  28. Mahadevan K, "Seaweed sustainability: food and nonfood applications", pp.347~364 (2015), Academic Press
  29. Markowska AL, "Insulin-like growth factor-1 ameliorates age-related behavioral deficits", Neuroscience, 87, pp.559~569 (1998)
  30. Martins S, "Bioactive phenolic compounds: production and extraction by solid-state fermentation. A review", Biotechnol Adv, 29, pp.365~373 (2011)
  31. Mecocci P, "Antioxidant clinical trials in mild cognitive impairment and Alzheimer’s disease", Biochim Bio-phys Acta, 1822, pp.631~638 (2012)
  32. Nasreddine ZS, "The Montreal cognitive assessment, MoCA : a brief screening tool for mild cognitive impairment", J Am Geriatr Soc, 53, pp.695~699 (2005)
  33. Ossoukhova A, "Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults", Hum Psychopharmacol Clin Exp, 30, pp.108~122 (2015)
  34. Ozer J, "The current state of serum biomarkers of hepatotoxicity", Toxicology, 245, pp.194~205 (2008)
  35. Ji-Sook Han, "Radical Scavenging and Antioxidant Activities of Fermented Laminaria japonica Extracts", Preventive Nutrition and Food Science, 11(2), pp.10~16 (2006), 한국식품영양과학회
  36. Reid SNS, "The effects of fermented Laminaria japonica on short-term working memory and physical fitness in the elderly", Evid Based Complement Alternat Med, 2018, pp.8109621~ (2018)
  37. Socci V, "Enhancing human cognition with cocoa flavonoids", Front Nutr, 4, pp.19~ (2017)
  38. Spellman T, "Hippocampal–prefrontal input supports spatial encoding in working memory", Nature, 522, pp.309~314 (2015)
  39. Sytze van Dam P, "Insulin-like growth factor-I, cognition and brain aging", Eur J Pharmacol, 490, pp.87~95 (2004)
  40. Um MY, "Phlorotannin-rich fraction from Ishige foliacea brown seaweed prevents the scopolamine-induced memory impairment via regulation of ERKCREB-BDNF pathway", J Funct Foods, 40, pp.110~116 (2018)
  41. Wang J, "Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica", Int J Biol Macromol, 42, pp.127~132 (2008)
  42. Wojtunik-Kulesza KA, "The influence of common free radicals and antioxidants on development of Alzheimer’s disease", Biomed Pharmacother, 78, pp.39~49 (2016)
  43. Yang H, "Anti-proliferative activity of phlorotannin extracts from brown algae Laminaria japonica Aresch", Chin J Oceanol Limnolgy, 28, pp.122~130 (2010)
  44. Yeom TH, "Korean version Wechsler Adult Intelligence Scale", pp.13~28 (1992), Korean Guidance
  45. Zha XQ, "Polysaccharides in Laminaria japonica(LP) : extraction, physicochemical properties and their hypolipidemic activities in diet-induced mouse model of atherosclerosis", Food Chem, 134, pp.244~252 (2012)
  46. Zhang Z, "ACE I", D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment, 2011, pp.218, 114~120

관련 논문AI추천

Effects of Fermented Sea Tangle Supplementation on the Oxidative Stress and DNA Damage in Older Women전병환대한운동학회 · 아시아 운동학 학술지2019 · 제21권 제2호GABA-enriched fermented Laminaria japonica improves cognitive impairment and neuroplasticity in scopolamine- and ethanol-induced dementia model mice김윤숙, 유제광, 전병환, Storm N. S. Reid한국영양학회 · Nutrition Research and Practice2018 · 제12권 제3호정상 동물모델에서 다시마(Saccharina japonica) 발효물의 기억력 개선 효과유제광, 이배진, 장성준, 조용홍한국수산과학회 · 한국수산과학회지2016 · 제49권 제2호Phlorotannin Supplement Improves Scopolamine-Induced Memory Dysfunction by Rescuing Synaptic Damage in MiceCho Seungmok, Kim Minji, Kwon Sangoh, Lee Haeun, Um Min Young한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2024 · 제34권 제11호Effects of the Combination Herbal Extract on Working Memory and White Matter Integrity in Healthy Individuals with Subjective Memory Complaints : A Randomized, Double-Blind, Placebo-Controlled Clinical Trial강일향, 권오란, 김경희, 김주희, 반순현, 윤수정, 이두석, 이상곤, 이선혜, 이선호, 이은희, 임수미, 임주연대한생물정신의학회 · 생물정신의학2015 · 제22권 제2호Actinidia arguta Sprout as a Natural Antioxidant: Ameliorating Effect on Lipopolysaccharide-Induced Cognitive Impairment강정은, 강진용, 권봉석, 김종민, 박상현, 박선경, 유슬기, 이창준, 허호진한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2021 · 제31권 제1호

이 간행물의 다른 논문 (4건)