정상 동물모델에서 다시마(Saccharina japonica) 발효물의 기억력 개선 효과
Memory-Improving Effects of Fermented Sea Tangle Saccharina japonica in Normal Mice
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초록
Marine organisms are sources of many bioactive compounds, such as essential fatty acids, essential amino acids, vitamins, and minerals, making them useful candidates for the production of safe bioactive substances. They also synthesize glutamic acid, which can be used to produce γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system (CNS), via fermentation with Lactobacillus brevis BJ-20. This study investigated the degree to which fermented sea tangle (FST) inhibits enzymes such as acetylcholine esterase (AChE) and prolyl endopeptidase (PEP) and affects memory of normal mice using the T-maze test. FST inhibited more than 90% of AChE at 1 mg/mL and 50% of PEP at 8 mg/mL. Oral FST (100 mg/kg) significantly improved performance of normal mice on the T-maze. Therefore, sea tangle fermented with L. brevis BJ20 effectively contributes to memory improvement and might be a useful functional food ingredient
Abstract
Marine organisms are sources of many bioactive compounds, such as essential fatty acids, essential amino acids, vitamins, and minerals, making them useful candidates for the production of safe bioactive substances. They also synthesize glutamic acid, which can be used to produce γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system (CNS), via fermentation with Lactobacillus brevis BJ-20. This study investigated the degree to which fermented sea tangle (FST) inhibits enzymes such as acetylcholine esterase (AChE) and prolyl endopeptidase (PEP) and affects memory of normal mice using the T-maze test. FST inhibited more than 90% of AChE at 1 mg/mL and 50% of PEP at 8 mg/mL. Oral FST (100 mg/kg) significantly improved performance of normal mice on the T-maze. Therefore, sea tangle fermented with L. brevis BJ20 effectively contributes to memory improvement and might be a useful functional food ingredient
참고문헌 (39)
- Ralph F. Alderson, "Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture", Neuron, 5(3), pp.297~306 (1990), Elsevier BV[DOI]
- TAKAAKI AOYAGI, "Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.", The Journal of Antibiotics, 44(9), pp.949~955 (1991), Japan Antibiotics Research Association[DOI]
- George L. Ellman, "A new and rapid colorimetric determination of acetylcholinesterase activity", Biochemical Pharmacology, 7(2), pp.88~95 (1961), Elsevier BV[DOI]
- Buchet R, "Alzheimer’s disease : Its origin at the membrane, evidence and questions", Acta Biochimica Polonica, 47, pp.725~733 (2000)
- 최미란, "마우스에서 복분자 물추출물의 기억력 감퇴에 대한 개선 효과", 한국식품영양과학회지, 41(2), pp.192~196 (2012), 한국식품영양과학회[DOI]
- Mirjana B. Colovic, "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology", Current Neuropharmacology, 11(3), pp.315~335 (2013), Bentham Science Publishers Ltd.[DOI]
- Robert M J Deacon, "T-maze alternation in the rodent", Nature Protocols, 1(1), pp.7~12 (2006), Springer Nature[DOI]
- FERNANDA G. DEFELICE, "Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease", Anais da Academia Brasileira de Ciências, 74(2), pp.265~284 (2002), FapUNIFESP (SciELO)[DOI]
- Yukinobu Ikeya, "Cognitive Improving and Cerebral Protective Effects of Acylated Oligosaccharides in Polygala tenuifolia", Biological & Pharmaceutical Bulletin, 27(7), pp.1081~1085 (2004), Pharmaceutical Society of Japan[DOI]
- 제갈경환, "스코폴라민으로 유도된 기억력 손상에 대한 복신의 보호 효과 및 작용기전 연구", 동의생리병리학회지, 24(2), pp.228~235 (2010), 한의병리학회
- 정연섭, "10가지 식용식물 추출물의 가바, 글루탐산 함량, 아세틸콜린에스테라제 억제 및 라디컬 소거능 비교", 한국식품과학회지, 44(4), pp.447~451 (2012), 한국식품과학회
- A. Kalueff, "Role of GABA in memory and anxiety", Depression and Anxiety, 4(3), pp.100~110 (1996), Wiley-Blackwell[DOI]
- Kang YM, "Antioxidant effects of fermented sea tangle (Laminaria japonica) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: a randomized, double-blind, and placebo-controlled clinical study", Food Chem Toxicol, 50, pp.1166~1169 (2012)[DOI]
- 강영미, "Lactobacillus brevis BJ20를 이용한 굴(Crassostrea gigas)ㆍ다시마 (Saccharina japonica) 발효 분말의 항산화 및 항염증 활성 효과", 한국수산과학회지, 46(4), pp.359~364 (2013), 한국수산과학회[DOI]
- Kim JH, "Prolyl endopeptidase inhibitors from green tea", Arch Pharm Res, 24, pp.292~296 (2001)[DOI]
- 엄민영, "생약추출물의 acetylcholinesterase 저해, 항산화 및 신경세포보호 효과in vitro 탐색", 한국식품저장유통학회지, 20(6), pp.840~845 (2013), 한국식품저장유통학회
- 국무창, "Enhanced Production of γ-Aminobutyric Acid Using Rice Bran Extracts by Lactobacillus sakei B2-16", Journal of Microbiology and Biotechnology, 20(4), pp.763~766 (2010), 한국미생물·생명공학회[DOI]
- Peter Kása, "The cholinergic system in Alzheimer's disease", Progress in Neurobiology, 52(6), pp.511~535 (1997), Elsevier BV[DOI]
- 곽지현, "저장 조건에 따른 녹차 추출물의 acetylcholinesterase(AChE) 저해 효과", 한국식품과학회지, 41(4), pp.435~440 (2009), 한국식품과학회
- 권유리, "추출방법에 따른 쇠비름의 항산화, 생리활성 및 Acetylcholinesterase 저해활성", 한국식품영양과학회지, 43(3), pp.389~396 (2014), 한국식품영양과학회
- Bae-Jin Lee, "Antioxidant activity and γ-aminobutyric acid (GABA) content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods", Food Chemistry, 122(1), pp.271~276 (2010), Elsevier BV[DOI]
- Lee HJ, "Inhibitory activities of seaweeds on prolyl endopeptidase, tyrosinase and coagulation", Korean J Pharmacogn, 30, pp.231~237 (1999)
- Lee KH, "Screening of prolyl endopeptidase inhibitors from natural products", Yakhak Hoeji, 41, pp.153~160 (1997)
- 이성현, "천연 식품자원으로부터 Prolyl Endopeptidase의 저해 효과 탐색", 한국식품영양과학회지, 32(7), pp.971~975 (2003), 한국식품영양과학회[DOI]
- P.T. Männisto, "Prolyl oligopeptidase: A potential target for the treatment of cognitive disorders", Drug News & Perspectives, 20(5), pp.293~305 (2007), Prous Science[DOI]
- A. Kimberley McAllister, "NEUROTROPHINS AND SYNAPTIC PLASTICITY", Annual Review of Neuroscience, 22(1), pp.295~318 (1999), Annual Reviews[DOI]
- Mehta M, "New acetylcholinesterase inhibitors for Alzheimer’s disease", Int J Alzheimers Dis, 2012, pp.1~8 (2012)[DOI]
- K.D. Murray, "Differential regulation of brain-derived neurotrophic factor and type II calcium", calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease, 1994, pp.60(1), 37~48[DOI]
- 박현정, "Fermented Saccharina japonica (Phaeophyta) improves neuritogenic activity and TMT-induced cognitive deficits in rats", ALGAE, 31(1), pp.73~84 (2016), 한국조류학회I
- Schneider JS, "Effects of the prolyl endopeptidnase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys", Neuropsychopharmacology, 26, pp.176~182 (2002)[DOI]
- Masahiko Shinoda, "Specific Inhibitor for Prolyl Endopeptidase Suppresses the Generation of Amyloid β Protein in NG108-15 Cells", Biochemical and Biophysical Research Communications, 235(3), pp.641~645 (1997), Elsevier BV[DOI]
- Hirotaka Shoji, "T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice", Journal of Visualized Experiments, (60), pp.e3300~ (2012), MyJove Corporation[DOI]
- SOICHIRO TODA, "Eurystatins A and B, new prolyl endopeptidase inhibitors. I. Taxonomy, production, isolation and biological activities", The Journal of Antibiotics, 45(10), pp.1573~1579 (1992), Japan Antibiotics Research Association[DOI]
- Vincenzo Nicola Talesa, "Acetylcholinesterase in Alzheimer's disease", Mechanisms of Ageing and Development, 122(16), pp.1961~1969 (2001), Elsevier BV[DOI]
- K. Toide, "Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP-4819, on Spatial Memory and Central Cholinergic Neurons in Aged Rats", Pharmacology Biochemistry and Behavior, 56(3), pp.427~434 (1997), Elsevier BV[DOI]
- 육동연, "마우스에서 L-Theanine의 기억력 회복능 및 Acetylcholinesterase 활성 억제", 약 학 회 지, 51(6), pp.409~414 (2007), 대한약학회
- SOICHIRO TODA, "Eurystatins A and B, new prolyl endopeptidase inhibitors. I. Taxonomy, production, isolation and biological activities", The Journal of Antibiotics, 45(10), pp.1573~1579 (1992), Japan Antibiotics Research Association[DOI]
- Vincenzo Nicola Talesa, "Acetylcholinesterase in Alzheimer's disease", Mechanisms of Ageing and Development, 122(16), pp.1961~1969 (2001), Elsevier BV[DOI]
- K. Toide, "Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP-4819, on Spatial Memory and Central Cholinergic Neurons in Aged Rats", Pharmacology Biochemistry and Behavior, 56(3), pp.427~434 (1997), Elsevier BV[DOI]