Effects of the Combination Herbal Extract on Working Memory and White Matter Integrity in Healthy Individuals with Subjective Memory Complaints : A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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ObjectivesZZThe combination extract of four kinds of herbs, Gastrodia elata, Liriope platyphylla, Dimocarpus longan, and Salvia miltiorrhiza, has shown to have memory improving effects in mice. The aim of this study was to investigate the efficacy and safety of the herbal mixture for improving working memory as well as microstructural changes in white matter integrity in individuals with subjective memory complaints. MethodsZZSeventy-five individuals with subjective memory complaints were assigned to receive either placebo (n = 15) or herbal mixture (low-dose group, n = 30 and high-dose group, n = 30) supplementation in an 8-week, randomized, double-blind, placebocontrolled clinical trial. Changes in working memory performance and fractional anisotropy (FA) values reflecting white matter integrity from baseline to 8-week endpoint were assessed. ResultsZZThe herbal mixture group showed an increase in working memory performance compared to the placebo group (p for interaction = 0.001). In addition, the herbal mixture group showed an increase in FA values in the temporo-parietal regions (corrected p < 0.05), which are crucially involved in working memory function and are among the most affected regions in patients with cognitive impairments. ConclusionsZZFindings from this study indicate that the herbal mixture may be a promising therapeutic option for individuals with subjective memory complaints.
Abstract
ObjectivesZZThe combination extract of four kinds of herbs, Gastrodia elata, Liriope platyphylla, Dimocarpus longan, and Salvia miltiorrhiza, has shown to have memory improving effects in mice. The aim of this study was to investigate the efficacy and safety of the herbal mixture for improving working memory as well as microstructural changes in white matter integrity in individuals with subjective memory complaints. MethodsZZSeventy-five individuals with subjective memory complaints were assigned to receive either placebo (n = 15) or herbal mixture (low-dose group, n = 30 and high-dose group, n = 30) supplementation in an 8-week, randomized, double-blind, placebocontrolled clinical trial. Changes in working memory performance and fractional anisotropy (FA) values reflecting white matter integrity from baseline to 8-week endpoint were assessed. ResultsZZThe herbal mixture group showed an increase in working memory performance compared to the placebo group (p for interaction = 0.001). In addition, the herbal mixture group showed an increase in FA values in the temporo-parietal regions (corrected p < 0.05), which are crucially involved in working memory function and are among the most affected regions in patients with cognitive impairments. ConclusionsZZFindings from this study indicate that the herbal mixture may be a promising therapeutic option for individuals with subjective memory complaints.
참고문헌 (74)
- Stewart R, "Subjective cognitive impairment", Curr Opin Psychiatry, 25, pp.445~450 (2012)
- von Gunten A, "Cognitive and demographic determinants of dementia in depressed patients with subjective memory complaints", Eur Neurol, 54, pp.154~158 (2005)
- Waldorff FB, "Subjective memory complaints in general practice predicts future dementia: a 4-year follow-up study", Int J Geriatr Psychiatry, 27, pp.1180~1188 (2012)
- Reid LM, "Subjective memory complaints and cognitive impairment in older people", Dement Geriatr Cogn Disord, 22, pp.471~485 (2006)
- Schofield PW, "Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment", Am J Psychiatry, 154, pp.609~615 (1997)
- Bassel C, "Working memory performance predicts subjective cognitive complaints in HIV infection", Neuropsychology, 16, pp.400~410 (2002)
- Gray JR, "Neural mechanisms of general fluid intelligence", Nat Neurosci, 6, pp.316~322 (2003)
- Johansson B, "Working memory training for patients with acquired brain injury: effects in daily life", Scand J Occup Ther, 19, pp.176~183 (2012)
- Westerberg H, "Computerized working memory training after stroke--a pilot study", Brain Inj, 21, pp.21~29 (2007)
- Cohen JD, "Temporal dynamics of brain activation during a working memory task", Nature, 386, pp.604~608 (1997)
- Laroche S, "Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation", Hippocampus, 10, pp.438~446 (2000)
- Serby MJ, "A study of herbal remedies for memory complaints", J Neuropsychiatry Clin Neurosci, 22, pp.345~347 (2010)
- Lee DS, "Ameliorating effects of HX106N, a water-soluble botanical formulation, on Aβ25-35-induced memory impairment and oxidative stress in mice", Biol Pharm Bull, 37, pp.954~960 (2014)
- 최선일, "Precautionary effects of Red Liriope platyphylla on NGF secretion and Aβ42 deposition under the preclinical stage of Alzheimer's disease in Tg2576 mice", Laboratory Animal Research, 29(4), pp.212~220 (2013), 한국실험동물학회
- Lee YK, "Differential regulation of the biosynthesis of glucose transporters by the PI3-K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla", Int J Mol Med, 27, pp.319~327 (2011)
- Lee YW, "Neuroprotective effects of salvianolic acid B on an Aβ25-35 peptide-induced mouse model of Alzheimer’s disease", Eur J Pharmacol, 704, pp.70~77 (2013)
- Lin AM, "Neuroprotective effects of longan (Dimocarpus longan Lour.) flower water extract on MPP+-induced neurotoxicity in rat brain", J Agric Food Chem, 60, pp.9188~9194 (2012)
- Tsai CF, "The neuroprotective effects of an extract of Gastrodia elata", J Ethnopharmacol, 138, pp.119~125 (2011)
- Tsai YC, "The oestrogenic and anti-platelet activities of dihydrobenzofuroisocoumarins and homoisoflavonoids from Liriope platyphylla roots", Food Chem, 140, pp.305~314 (2013)
- Ho SC, "Suppressive effect of a proanthocyanidin-rich extract from longan (Dimocarpus longan Lour.)flowers on nitric oxide production in LPS-stimulated macrophage cells", J Agric Food Chem, 55, pp.10664~10670 (2007)
- Yu SJ, "Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions", Biol Pharm Bull, 28, pp.1016~1020 (2005)
- Bartzokis G, "Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study", Arch Gen Psychiatry, 58, pp.461~465 (2001)
- Kane MJ, "The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: an individual-differences perspective", Psychon Bull Rev, 9, pp.637~671 (2002)
- 최성혜, "한국판 Global Deterioration Scale의 타당도", 대한신경과학회지, 20(6), pp.612~617 (2002), 대한신경과학회
- Roth M, "CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia", Br J Psychiatry, 149, pp.698~709 (1986)
- Zandi T, "Relationship between subjective memory complaints, objective memory performance, and depression among older adults", Am J Alzheimers Dis Other Demen, 19, pp.353~360 (2004)
- Choi SH, "Dementia Research Group. Estimating the validity of the Korean version of Expanded Clinical Dementia Rating (CDR) scale", J Korean Neurol Assoc, 19, pp.585~591 (2001)
- Reay JL, "Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults", Hum Psychopharmacol, 25, pp.462~471 (2010)
- Dumville JC, "Reporting attrition in randomised controlled trials", BMJ, 332, pp.969~971 (2006)
- "Korea:Regulation on Approval of Functional ingredient and of Standard/Specification for Health Functional Food" (2013)[URL]
- Schmand B, "Subjective memory complaints may announce dementia", Neurology, 46, pp.121~125 (1996)
- Wechsler D, "Wechsler Memory Scale-Fourth Edition (WMS-IV):technical and interpretive manual" (2009), Pearson
- Strauss E, "Compendium of Neuropsychological Tests: administration, norms, and commentary" (2006), Oxford University Press
- Beglinger LJ, "Practice effects and the use of alternate forms in serial neuropsychological testing", Arch Clin Neuropsychol, 20, pp.517~529 (2005)
- Gregoire J, "Effects of age on forward and backward digit spans", Aging Neuropsychol Cogn, 4, pp.140~149 (1997)
- Levine AJ, "Normative data for determining significance of test-retest differences on eight common neuropsychological instruments", Clin Neuropsychol, 18, pp.373~384 (2004)
- Iwasaki K, "A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine “ba wei di huang wan” in the treatment of dementia", J Am Geriatr Soc, 52, pp.1518~1521 (2004)
- Kim J, "Enhancing effect of HT008-1 on cognitive function and quality of life in cognitively declined healthy adults: a randomized, double-blind, placebo-controlled, trial", Pharmacol Biochem Behav, 90, pp.517~524 (2008)
- Unsworth N, "On the division of short-term and working memory: an examination of simple and complex span and their relation to higher order abilities", Psychol Bull, 133, pp.1038~1066 (2007)
- Hoelzle JB, "Comparison of Wechsler Memory Scale-Fourth Edition (WMS-IV) and Third Edition (WMS-III)dimensional structures: improved ability to evaluate auditory and visual constructs", J Clin Exp Neuropsychol, 33, pp.283~291 (2011)
- Lu PH, "Effectiveness of the Rey-Osterrieth Complex Figure Test and the Meyers and Meyers recognition trial in the detection of suspect effort", Clin Neuropsychol, 17, pp.426~440 (2003)
- Engle RW, "Working memory, short-term memory, and general fluid intelligence: a latent-variable approach", J Exp Psychol Gen, 128, pp.309~331 (1999)
- Johnson MK, "The relationship between working memory capacity and broad measures of cognitive ability in healthy adults and people with schizophrenia", Neuropsychology, 27, pp.220~229 (2013)
- Nouchi R, "Beneficial effects of short-term combination exercise training on diverse cognitive functions in healthy older people: study protocol for a randomized controlled trial", Trials, 13, pp.200~ (2012)
- Wroolie TE, "Differences in verbal memory performance in postmenopausal women receiving hormone therapy: 17β-estradiol versus conjugated equine estrogens", Am J Geriatr Psychiatry, 19, pp.792~802 (2011)
- Dobbs AR, "Adult age differences in working memory", Psychol Aging, 4, pp.500~503 (1989)
- Salthouse TA, "Mediation of adult age differences in cognition by reductions in working memory and speed of processing", Psychol Sci, 2, pp.179~183 (1991)
- Keefe RS, "Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison", Am J Psychiatry, 164, pp.1061~1071 (2007)
- Milbury K, "Tibetan sound meditation for cognitive dysfunction: results of a randomized controlled pilot trial", Psychooncology, 22, pp.2354~2363 (2013)
- Duff SJ, "A sex difference on a novel spatial working memory task in humans", Brain Cogn, 47, pp.470~493 (2001)
- Kaufman SB, "Sex differences in mental rotation and spatial visualization ability: can they be accounted for by differences in working memory capacity?", Intell, 35, pp.211~223 (2007)
- Shelton JT, "A Comparison of Laboratory and Clinical Working Memory Tests and Their Prediction of Fluid Intelligence", Intelligence, 37, pp.283~ (2009)
- Diabetes Control and Complications Trial, "Epidemiology of Diabetes Interventions and Complications Study Research Group", Long-term effect of diabetes and its treatment on cognitive function, 2007, pp.356, 1842~1852
- Kennedy DO, "Ginseng: potential for the enhancement of cognitive performance and mood", Pharmacol Biochem Behav, 75, pp.687~700 (2003)
- Behrens TE, "Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging", Nat Neurosci, 6, pp.750~757 (2003)
- Smith SM, "Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data", Neuroimage, 31, pp.1487~1505 (2006)
- Lingjaerde O, "The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients", Acta Psychiatr Scand Suppl, 334, pp.1~100 (1987)
- West BT, "Linear mixed models: a practical guide using statistical software", pp.2007, Chapman & Hall
- Gildengers AG, "The longitudinal course of cognition in older adults with bipolar disorder", Bipolar Disord, 11, pp.744~752 (2009)
- Nichols TE, "Nonparametric permutation tests for functional neuroimaging: a primer with examples", Hum Brain Mapp, 15, pp.1~25 (2002)
- Avery AJ, "A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis", Lancet, 379, pp.1310~1319 (2012)
- Bodini B, "Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: an in vivo study with TBSS and VBM", Hum Brain Mapp, 30, pp.2852~2861 (2009)
- Squire LR, "The medial temporal lobe", Annu Rev Neurosci, 27, pp.279~306 (2004)
- Stewart R, "Neuroimaging correlates of subjective memory deficits in a community population", Neurology, 70, pp.1601~1607 (2008)
- Karlsgodt KH, "Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia", Biol Psychiatry, 63, pp.512~518 (2008)
- Vestergaard M, "White matter microstructure in superior longitudinal fasciculus associated with spatial working memory performance in children", J Cogn Neurosci, 23, pp.2135~2146 (2011)
- Medina D, "White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study", Neurobiol Aging, 27, pp.663~672 (2006)
- Head D, "Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging", Cereb Cortex, 14, pp.410~423 (2004)
- Malik R, "Towards better brain management: nootropics", Curr Med Chem, 14, pp.123~131 (2007)
- Kim HJ, "Ethyl ether fraction of Gastrodia elata Blume protects amyloid beta peptide-induced cell death", J Ethnopharmacol, 84, pp.95~98 (2003)
- Jong Hoon RYU, "Neurotrophic Factors Mediate Memory Enhancing Property of Ethanolic Extract of Liriope platyphylla in Mice", Biomolecules & Therapeutics, 15(2), pp.83~88 (2007), 한국응용약물학회
- Pan YM, "Antioxidant activity of microwave-assisted extract of longan (Dimocarpus Longan Lour.) peel", Food Chem, 106, pp.1264~1270 (2008)
- Ribnicky DM, "Evaluation of botanicals for improving human health", Am J Clin Nutr, 87, pp.472S~475S (2008)
- Wakana S, "Reproducibility of quantitative tractography methods applied to cerebral white matter", Neuroimage, 36, pp.630~644 (2007)
