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무기인산염 함유 이상성 인산칼슘이 외방성 수직골 형성에 미치는 영향

The effect of micro-macroporous biphasic calcium phosphate incoporated with polyphosphate on exophytic bone regeneration

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초록

Purpose: In this study, the effect of micro-macroporous biphasic calcium phosphate(MBCP) incorporated with inorganic polyphosphate for bone regeneration in the calvaria of rabbit was evaluated. Materials and Methods: The procedure of guided bone regeneration was performed with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. Four animal groups were compared : 1) TR-ePTFE membrane for negative control group, 2) TR-ePTFE membrane filled with MBCP for positive control group, 3) TR-ePTFE membrane filled with MBCP soaked in 4% inorganic polyphosphate for experimental group I, and 4) TR-ePTFE membrane filled with MBCP soaked in 8% inorganic polyphosphate for experimental group II. Results: 1. Negative control group showed the highest new bone formation at 16 weeks. 2. Positive control group showed the smallest new bone formation compared to other groups. 3. 8% inorganic polyphosphate induced more volume of bone formation, otherwise experimental group II did not show significant difference compared to negative control group. Conclusion: These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration, possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue. (J Korean Acad Periodontol 2008;38:179-190)

Abstract

Purpose: In this study, the effect of micro-macroporous biphasic calcium phosphate(MBCP) incorporated with inorganic polyphosphate for bone regeneration in the calvaria of rabbit was evaluated. Materials and Methods: The procedure of guided bone regeneration was performed with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. Four animal groups were compared : 1) TR-ePTFE membrane for negative control group, 2) TR-ePTFE membrane filled with MBCP for positive control group, 3) TR-ePTFE membrane filled with MBCP soaked in 4% inorganic polyphosphate for experimental group I, and 4) TR-ePTFE membrane filled with MBCP soaked in 8% inorganic polyphosphate for experimental group II. Results: 1. Negative control group showed the highest new bone formation at 16 weeks. 2. Positive control group showed the smallest new bone formation compared to other groups. 3. 8% inorganic polyphosphate induced more volume of bone formation, otherwise experimental group II did not show significant difference compared to negative control group. Conclusion: These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration, possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue. (J Korean Acad Periodontol 2008;38:179-190)

참고문헌 (40)

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관련 논문AI추천

무기인산염이 외방성 수직골 형성에 미치는 영향이진, 허익, 권영혁, 박준봉, 정종혁대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제1호삼차원적으로 연결된 미세다공성 구조를 가진 이상인산칼슘 골이식재의 골치유에 관한 조직계측학적 평가류경호, 박광범, 박진우, 서조영, 이재목, 이종식, 장제희, 최석규대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제2호토끼 두개골에서 새로 개발된 biphasic calcium phosphate의 골형성 효과 : A pilot study김성태, 김종관, 박상현, 박준효, 엄유정, 이용호, 조규성, 최성호, 홍지연대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제2호Effect of MBCP block as carrier of rhBMP-2 in combination with ePTFE membrane on bone formation in rat calvarial defects김창성, 신철우, 윤정호, 정성원, 조규성, 최성호대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제2호성견 일벽성 치주 결손부에 이식한 biphasic calcium phosphate의 조직계측학적 평가김동진, 김성태, 김종관, 연제영, 이용호, 조규성, 최성호, 홍성배, 홍지연대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제2호토끼 두개골 결손부에서 블록형과 분말형 hydroxyapatite의 골전도 효과구순자, 김창성, 손주연, 엄유정, 이용근, 임현창, 정의원, 최성호대한치주과학회 · Journal of Periodontal & Implant Science2009 · 제39권 제3호

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