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Dissolution behavior and early bone apposition of calcium phosphate-coated machined implants

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Purpose: Calcium phosphate (CaP)-coated implants promote osseointegration and survival rate. The aim of this study was to(1) analyze the dissolution behavior of the residual CaP particles of removed implants and (2) evaluate bone apposition of CaPcoatedmachined surface implants at the early healing phase. Methods: Mandibular premolars were extracted from five dogs. After eight weeks, the implants were placed according to drillingprotocols: a nonmobile implant (NI) group and rotational implant (RI) group. For CaP dissolution behavior analysis, 8 implantswere removed after 0, 1, 2, and 4 weeks. The surface morphology and deposition of the coatings were observed. For boneapposition analysis, block sections were obtained after 1-, 2-, and 4-week healing periods and the specimens were analyzed. Results: Calcium and phosphorus were detected in the implants that were removed immediately after insertion, and the otherimplants were composed mainly of titanium. There were no notable differences between the NI and RI groups in terms ofthe healing process. The bone-to-implant contact and bone density in the RI group showed a remarkable increase after 2 weeksof healing. Conclusions: It can be speculated that the CaP coating dissolves early in the healing phase and chemically induces early boneformation regardless of the primary stability.

Abstract

Purpose: Calcium phosphate (CaP)-coated implants promote osseointegration and survival rate. The aim of this study was to(1) analyze the dissolution behavior of the residual CaP particles of removed implants and (2) evaluate bone apposition of CaPcoatedmachined surface implants at the early healing phase. Methods: Mandibular premolars were extracted from five dogs. After eight weeks, the implants were placed according to drillingprotocols: a nonmobile implant (NI) group and rotational implant (RI) group. For CaP dissolution behavior analysis, 8 implantswere removed after 0, 1, 2, and 4 weeks. The surface morphology and deposition of the coatings were observed. For boneapposition analysis, block sections were obtained after 1-, 2-, and 4-week healing periods and the specimens were analyzed. Results: Calcium and phosphorus were detected in the implants that were removed immediately after insertion, and the otherimplants were composed mainly of titanium. There were no notable differences between the NI and RI groups in terms ofthe healing process. The bone-to-implant contact and bone density in the RI group showed a remarkable increase after 2 weeksof healing. Conclusions: It can be speculated that the CaP coating dissolves early in the healing phase and chemically induces early boneformation regardless of the primary stability.

참고문헌 (38)

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