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유방암의 Claudin-7 발현 감소와 침습력 및 핵등급과의관련성

Reduced Expression of Claudin-7 Correlates withInvasiveness and Nuclear Grade of Breast Carcinomas

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Abstract

Background : Claudins are important components of the tight junctions in the intercellular barriers and cell polarity. Among them, claudin-7 is down-regulated in breast cancers compared with the normal breast epithelium. The aim of this study was to determine the expression pattern and prognostic value of claudin-7 in breast carcinomas. Methods : Claudin-7 expression was evaluated immunohistochemically in 42 cases of ductal carcinoma in situ (DCIS) and in 142 cases of invasive breast carcinoma (IBC) using a tissue microarray (TMA). Results : Claudin- 7 was strongly expressed in the normal luminal epithelial cells in the breast lobule. The level of claudin-7 expression was significantly lower or absent in 45.2% (19/42) of DCIS and 72.5% (103/142) of IBC. A loss or reduced expression of claudin-7 correlated with the invasiveness (p=0.001) of breast carcinomas and a high nuclear grade (p=0.013) in IBC. Conclusion : Claudin-7 is an important tight junction protein in the breast and a loss of expression may assist in the dissociation and invasion of tumor cells.

참고문헌 (26)

  1. "et al. Expression of E-cadherincell adhesion molecules in human breast cancer tissues and its relationshipto metastasis. Cancer Res 1993", pp.1696~701
  2. "E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance", 46, pp.685~693 (2005)
  3. "E-cadherin immunohistochemical expression as a prognostic factor in infiltrating ductal carcinoma of the breast: a systematic review and meta-analysis", 100, pp.139~148 (2006)
  4. "Molecular physiology and pathophysiology of tight junctions I. tight junction structure and function: lesions from mutant animals and proteins", 279, pp.250~254 (2000)
  5. "The claudin gene family: expression in normal and neoplastic tissues", 6, pp.186~ (2006)
  6. "Molecular architecture of tight junctions", 60, pp.121~142 (1998)
  7. "Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours", 46, pp.551~560 (2005)
  8. "Claudin proteins in human cancer: promising new targets for diagnosis and therapy", 65, pp.9603~9606 (2005)
  9. "Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin- 4 in prostate cancer epithelium", 61, pp.7878~7881 (2001)
  10. "Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas", 9, pp.2567~2575 (2003)
  11. "Claudin- 4: a new target for pancreatic cancer treatment using clostridium perfringens enterotoxin", 121, pp.678~684 (2001)
  12. "Loss of the tight junction protein claudin-7 correlates with histologicalal grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast", 22, pp.2021~2033 (2003)
  13. "Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells", 21, pp.2634~264 (2002)
  14. "Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis", 167, pp.577~584 (2005)
  15. "Ellis IO. Pathological prognostic factors in breast cancer.I. The value of histological grade in breast cancer experience froma large study with long-term follow-up. Histopathology 1991", pp.403~10
  16. "Consensus conference on the classification of ductal carcinoma in situ", 80, pp.1798~1802 (1997)
  17. "Specificity of HercepTest in determinig HER2", neu status of breast cancers using the United States Food and Drug Administration-approved scoring system, 1999, pp.17, 1983~1987
  18. "An immunohistochemical examination of the expression of E-cadherin, alpha- and beta", gamma-catenins, and alpha2- and beta1-integrins in invasive breast cancer, 1999, pp.187, 523~529
  19. "Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut", 120, pp.411~422 (2001)
  20. "Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gamma-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis", 115, pp.52~65 (2007)
  21. "Reduced expression of claudin-7 in fine needle aspirates from breast carcinomas correlate with grading and metastatic disease", 16, pp.193~198 (2005)
  22. "Tissue microarrays for rapid linking of molecular changes to clinical endpoints", 159, pp.2249~2256 (2001)
  23. "microarray technology for high-throughput molecular profiling of cancer", 10, pp.657~662 (2001)
  24. "Reliability of tissue microarrays in detecting protein expression and gene amplification in breast cancer", 16, pp.79~84 (2003)
  25. "Validation of tissue microarray technology in ovarian carcinoma", 17, pp.790~797 (2004)
  26. "Validation of tissue microarray technology using cervical adenocarcinoma and its precursors as a model system", 16, pp.1225~1233 (2006)

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