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유방암종의 MMP-2와 MMP-9 발현과 예후 인자와의 연관성

MMP-2 and MMP-9 Expressions in Breast Carcinomas and Relationship with Major Prognostic Factors

박설미|윤혜경
대한병리학회|2004.04|Journal of Pathology and Translational Medicine|제38권 제2호|pp. 79-85

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참고문헌

주제분류병리학

초록

Abstract

Background : MMP-2 and MMP-9 are involved in the degradation of extracellular matrix, and MMP-2 and MMP-9 expressions in breast carcinomas have been reported as a poor prognostic factor. The aim of this study is to evaluate the prognostic value and the regulatory factors of MMP-2 and MMP-9 expressions in 73 cases of infiltrating ductal carcinomas, NOS type. Methods : Immunohistochemistry for MMP-1, -2, -3, -9 and TIMP-1, -2 were performed and evaluation for patient’s age, size, histologic grade, lymph node metastasis and tumor markers such as ER, PR, p53, c-erbB-2, cathepsin D, MIB-1, and microvessel density was done. Results : The expression rates of MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1 and TIMP-2 were 74.0%, 76.7%, 1.4%, 87.7%, 24.7% and 75.3%, respectively. MMP-2 expression rate was higher in the tumors of low and intermediate grade and PR positive tumors (p<0.05), and MMP-9 expression showed an increasing tendency in ER positive tumor (p=0.0676). Positive relationships between MMP-2 and MMP-1 expressions, and MMP-9 and TIMP-2 expressions were recognized (p<0.05). Conclusion : The prognostic significance of MMP-2 and MMP-9 expressions is still unclear, and MMP-2 and MMP-9 expressions seemed to be positively related with MMP-1 and TIMP-2 expression, respectively.

참고문헌 (25)

  1. "The role of proteolytic enzymes in cancer invasion andmetastasis", 10, pp.145~155 (1992)
  2. "Relationship between matrix met-alloproteinase expression and tumor angiogenesis in human breastcarcinoma", pp.673~677 (1998)
  3. "membrane type 1 matrix metalloproteinase, and extracellu-lar matrix metalloproteinase inducer mRNA expression: correlationwith invasive growth of breast cancer", 24, pp.334~340 (2000)
  4. "Dynamics of matrix turnover during patho-logic remodeling of the extracellular matrix", 148, pp.1345~1350 (1996)
  5. "Control of matrix metalloproteinase activityin cancer", 183, pp.377~379 (1997)
  6. "Increased gelati-nase-A and gelatinase-B activities in malignant vs benign breasttumors", 86, pp.204~207 (2000)
  7. "Expression oftissue inhibitor of metalloproteinase and type IV collagenase", gelati-nase messenger RNAs in human breast cancer, 1997, pp.28, 359~366
  8. "Activation of matrix metalloproteinase-9 (MMP-9)via a converging plasmin", stromelysin-1 cascade enhances tumorcell invasion, 1999, pp.274, 13066~13076
  9. "Production of matrix metalloproteinases and tissue inhibitors ofmetalloproteinases in human breast carcinomas", 87, pp.602~611 (1996)
  10. "Cancer metastasis andangiogenesis:an imbalance of positive and negative regulation", pp.327~336 (1991)
  11. "Membrane-type metalloproteinases (MT-MMPs)in tumor metastasis", 119, pp.209~215 (1996)
  12. "Matrix metalloproteinase-2 (MMP-2) is associated84 윤혜경박설미with the risk for a relapse in postmenopausal patients with node-positive breast carcinoma treated with antiestrogen adjuvant thera-py", 65, pp.55~61 (2001)
  13. "Expression of gelatinases A and B stromelysin-3 and matrilysingenes in breast carcinomas:clinico-pathological correlations,", 16, pp.577~585 (1998)
  14. "Immunohistochemicallocalization of matrix metalloproteinase 2 and its specific inhibitorTIMP-2 in neoplastic tissues with monoclonal antibodies", 56, pp.500~505 (1994)
  15. "Activity of type IV col-lagenases in benign and malignant breast disease", 67, pp.1126~1131 (1993)
  16. "72 KD and 92 KD type IV collagenase, type IV collagen, andlaminin mRNAs in breast cancer: a study by in situ hybridization", 42, pp.945~951 (1994)
  17. "Immunohistochemical distribution of type IV collagenasein normal,benign, and malignant breast tissue", 136, pp.585~592 (1990)
  18. "Enhanced expressionof tissue inhibitor of metalloproteinase-2 in the stroma of breastcarcinomas correlates with tumor recurrence", 59, pp.339~344 (1994)
  19. "Association betweenthe expression of MMP-2 and TIMP-2 and growth patterns of tumorborder and estrogen receptor in the invasiveductal carcinoma of the breast", 344, pp.366~373 (2000)
  20. "Expression of matrix metallo-proteinase and tissue inhibitor of metalloproteinase in breast carci-noma related to angiogenesis and invasion", 34, pp.652~64 (2000)
  21. "Expression of MMP-2 andTIMP-2 mRNA in breast carcinomas", 37, pp.400~406 (2003)
  22. "Matrix metalloproteinase-2 immunore-active protein: a marker of aggressiveness in breast carcinoma.", 83, pp.1153~1156 (1998)
  23. "MMP-2 positivity and age less than 40 years increases the risk for recurrencein premenopausal patients with node-positive breast carcinoma", 58, pp.287~293 (1999)
  24. "mRNA expressions ofTIMP-1,TIMP-2 and -3 and 92-KD type IV collgenase in early humanplacenta and decidual membranes as studied by in situ hybridization", 44, pp.1379~1388 (1996)
  25. "MMP-2 and TIMP-2 expressioncorrelates with poor prognosis in cervical carcinoma -A clinicopathologicstudy using immunohistochemistry and mRNA insitu hybridization", 73, pp.372~382 (1999)

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