본문 바로가기
KERD
논문KCI 등재

침윤성 유방암종과 관내암종에서 Cathepsin D 발현의 차이

The Difference of Cathepsin D Expression between Invasive Ductal Carcinoma and Ductal Carcinoma In Situ of the Breast

정수진|윤혜경
대한병리학회|2004.12|Journal of Pathology and Translational Medicine|제38권 제6호|pp. 408-414

1

조회

0

다운로드

0

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : It is known that cathepsin D expression in host stromal cells is associated with a more aggressive tumor behavior in breast cancers. Methods : Cathepsin D expression was examined in 222 cases of invasive ductal carcinoma (CA) and 25 cases of ductal carcinoma in situ (DCIS) by the immunohistochemical staining. Cathepsin D expression was evaluated according to the expression site, either in the tumor cells (CD-T) or in the stromal cells (CD-S), and graded according to the immunopositivity. The differences of CD-T and CD-S in each case were evaluated according to the pathologic parameters and estrogen receptor (ER)/progesterone receptor (PR) status. Results : The rate of CD-S was significantly higher in the CA than in the DCIS (p<0.0001). In the CA, the rate of CD-S was higher than that of CD-T, while in the DCIS, the rate of CD-T was higher than that of CD-S. In the CA, the rate of CD-S and the tumor grade showed a positive relationship (p=0.0281). There were positive correlations between the ER positivity and CD-S (p=0.0236), and between the PR positivity and CD-T (p=0.0246). For the DCIS, no significant relationships were noted between the pathologic parameters including ER/PR status and CD-T/CD-S. Conclusions : Cathepsin D expression in the stromal cells seems to be related to the invasiveness and aggressive biological behavior in breast cancers. In addition, there might be some relationship betweeen the ER positivity and CD-S, and between the PR positivity and CD-T.

참고문헌 (27)

  1. "Estradiol induced proteins in the MCF-7 human breast cancer cell line", pp.410~6
  2. "Cathepsin D detected by automatedand quantitative immunohistochemistry in breast carcinomas correlation with overall and disease free survival.", 50, pp.586~590 (1997)
  3. "Immunohistochemical analysis of cathepsins D and L in human breast cancer", pp.857~62
  4. "correlation with cytosolic assay", pp.863~71
  5. "Evaluation of cathepsin D as a prognostic factor in breastcancer", pp.219~26
  6. "Cathepsin D in host stromal cells is associated with more highlyvascular and aggressive invasive breast carcinoma.", 34, pp.35~42 (1999)
  7. "Immunohistochemical evaluationof invasion-associated proteases in breast carcinoma", pp.302~6
  8. "Cathepsin D in host stromal cells but not in tumor cells is associatedwith aggressive behavior in node-negative breast cancer.", 27, pp.890~895 (1996)
  9. "Immunohistochemicallocalization of cathepsin D proliferating cell nuclear antigen andepidermal growth factor receptor in human breast carcinoma analysedby computer image analyser correlation with histological gradeand metastatic behaviour.", pp.540~548 (1997)
  10. "Expression of cathepsin D and urokinase by reactivestromal cells on breast carcinoma prognosis.", 92, pp.2957~2964 (2001)
  11. "The role of cathepsinD in the invasiveness of human breast cancer cells", pp.873~7
  12. "Prognosticvalue of cathepsin-D expression in female breast cancer.", pp.1033~1037 (1995)
  13. "Cathepsin D in invasive ductal NOS breast carcinoma asdefined by immunohistochemistry No correlation with survival at5 years.", pp.1003~12
  14. "Prognostic significance of immunohistochemical analysis of cathepsinD in low stage breast cancer", pp.2756~63
  15. "Biological and clinical significance of cathepsin D inbreast cancer", pp.125~30
  16. "Immunohistochemicalcathepsin-D expression in breast cancer correlation with establishedpathological parameters and survival.", 197, pp.551~557 (2001)
  17. "Tumor Angiogenesis and cathepsin-D Expression in Invasive Ductal Carcinoma of the Breast.", 31, pp.735~744 (1997)
  18. "Cathepsin D and prognosis in breast cancer", pp.297~302
  19. "Cathepsin D expression detectedby immunohistochemistry has independent prognostic value in axillarynode-negative breast cancer", pp.36~43
  20. "Comparisonof different immunohistochemical methods in the assessmentof angiogenesis lack of prognostic value in a group of 77 selectednode-negative breast carcinoma.", 8, pp.745~752 (1995)
  21. "CathepsinD: association between TN-stage and steroid receptor statusof breast carcinoma.", 19, pp.329~334 (1998)
  22. "Immunocytochemical assay of cathepsin D in fineneedle aspiration cytology of breast carcinoma and benign breastdiseases.", 11, pp.75~81 (2000)
  23. "Immunohistochemicalassay of Cathepsin D in breast carcinoma.", 18, pp.65~69 (1995)
  24. "Cathepsin D and breast cancer.", 32, pp.15~24 (1996)
  25. "Specific oncological contributionof cathepsin D and pS2 in human breast cancer:their relationshipwith TNM status, estradiol receptors, epidermal growth factorreceptor and neu amplification.", 247, pp.89~103 (1996)
  26. "Relationship betweencathepsin D expression and other prognostic factors in primarybreast cancer.", 4, pp.172~178 (2001)
  27. "Increased expression ofcathepsin-D in breast cancer", pp.469~70

관련 논문AI추천

유방의 관암종과 소엽암종의 조직학적 감별 시 E-cadherin 단백 발현 양상강석진, 강창석, 이안희, 이은정, 장은덕대한병리학회 · Journal of Pathology and Translational Medicine2002 · 제36권 제5호유방의 양성병변 및 침윤성 관암종에서 Claudin-1 및 -4단백의 발현강석진, 유진영, 이교영, 정지한, 최현주대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제4호유방 관상피내암종의 조직학적 분류김동석영남대학교 의과대학 · Journal of Yeungnam Medical Science1997 · 제14권 제1호유방의 침윤성 관암종에서 Anaphase-promoting Complex의 발현과 예후 인자와의 관계강엽, 박광화, 엄민섭, 이광길, 이상엽, 정순희대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제1호유방 병변의 악성 진행에 따른 Survivin 단백 발현강석진, 강창석, 유진영, 이교영, 이은정, 정지한, 정찬권, 최현주대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제4호유방의 침윤성 관암종에서 p21, p53 및 bcl-2 단백의 발현문형배, 윤기중, 조향정대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제6호

이 간행물의 다른 논문 (13건)

자가면역 간질환군에서 PML단백의 발현비교김정선, 서동진, 정영화, 김현정, 유은실, 이한주, 김종재, 이영상pp. 357-363일시적 국소 뇌허혈손상에서 신경세포의 세포자멸사와 Inducible Nitric Oxide Synthase 발현이병육, 강구성, 손윤경, 전홍화, 곽은경, 김정완, 이영미, 박지영, 황성규pp. 364-371난소종양에서의 Melanoma Antigen Genes (MAGE)와 Synovial Sarcoma on X chromosome (SSX)의 발현김영옥, 박종욱, 김원, 장희경, 박진경, 전창호, 김광휘pp. 372-377Doxorubicin 투여 백서 심장의 심근과 신경 손상에 대한 Probucol과 Verapamil의 효과양우익, 이상엽, 조상호pp. 378-387위샘암종에서 CD24 발현과 종양 침습력의 연관성서재남, 정경천, 박영의, 송헌호, 오권익, 신형식, 김태운, 최영미pp. 388-393
원문 보기