본문 바로가기
KERD
논문KCI 등재

유방의 양성병변 및 침윤성 관암종에서 Claudin-1 및 -4단백의 발현

Expression of Claudin-1 and -4 in Benign Lesion and Invasive Ductal Carcinoma of the Breast

유진영|강석진|이교영|정지한|최현주
대한병리학회|2007.08|Journal of Pathology and Translational Medicine|제41권 제4호|pp. 232-237

2

조회

0

다운로드

2

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : The claudins are a family of transmembrane proteins associated with tight junctions and they are critical for maintaining cell-to-cell adhesion in sheets of epithelial cells. However, their role in the progression of cancer remains largely unexplored. The aims of this study were to evaluate the expression patterns of claudin-1 and -4 in benign lesions and invasive ductal carcinomas (IDC) of the breast, and relationships between the expression of these markers and the clinicopathological characteristics in IDC patients. Methods : We examined the claudin-1 and -4 protein expressions by performing immunohistochemical stainings in 54 benign lesions and 120 IDCs via the tissue microarray method. We evaluated the correlation between the expression of these markers and the clinicopathological characteristics of IDC. Results : The expressions of claudin-1 (p=0.099) and -4 (p=0.000) were up-regulated in IDCs as compared with benign lesions. The claudin-1 expression correlated with the loss of estrogen receptor (p=0.036) and progesterone receptor (p=0.011). The claudin-4 expression correlated with lymph node metastasis (p=0.043), the nuclear grade (p=0.030), the histologic grade (p=0.007), and the loss of estrogen receptor (p=0.001) and progesterone receptor (p= 0.029). Conclusions : These results suggest that claudin-1 and -4 may play a significant role in the carcinogenesis of IDC of the breast and these may represent novel markers for this disease.

참고문헌 (26)

  1. "implications for treatment. Br J Surg1994", pp.1576~90
  2. "Cell adhesion: the molecular basis of tissue architecture and morphogenesis", 84, pp.345~357 (1996)
  3. "Tight junction and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom", 81, pp.419~435 (2002)
  4. "Pores in the wall: claudins constitute tight junction strands containing aqueous pores", 149, pp.13~16 (2000)
  5. "Tight junction proteins", 81, pp.1~44 (2003)
  6. "A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells", 117, pp.1247~1257 (2004)
  7. "Claudin-1 and-2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin", 141, pp.1539~1550 (1998)
  8. "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast", 22, pp.2021~2033 (2003)
  9. "Weber BH. Genomicorganization of claudin-1 and its assessment in hereditary and sporadicbreast cancer. Hum Genet 2000", 107, pp.249~256 (2000)
  10. "-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study", 7, pp.248~255 (2005)
  11. "Involvement of claudin-1 in the bata-catenin", Tcf signaling pathway and its frequent upregulation in human colorectal cancers, 2000, pp.12, 469~476
  12. "Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer", 60, pp.6281~6287 (2000)
  13. "Pathological prognostic factors in breast cancer.I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up", pp.403~10
  14. "SommersSC. The pathology of invasive breast cancer. A Syllabus derivedfrom findings of the National Surgical Adjuvant Breast Project", protocol(4), pp.1~85
  15. "Increased tight junction permeability is associated with the development of colon cancer", 20, pp.1425~1431 (1999)
  16. "Claudin-based barrier in simple and stratified cellular sheets", 14, pp.531~536 (2002)
  17. "Molecular physiology and pathophysiology of tight junctions I. Tight junctions structure and function: lesions from mutant animals and proteins", 279, pp.250~254 (2000)
  18. "Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells", 21, pp.2634~2640 (2002)
  19. "Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive carcinoma", 36, pp.162~169 (2005)
  20. "Differential gene expression in ovarian carcinoma: identification of potential biomarkers", 165, pp.397~414 (2005)
  21. "Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4", 164, pp.1627~1633 (2004)
  22. "Expression of Clostridium perfringens enterotoxin receptors claudin 3 and claudin 4 in prostate cancer epithelium", 61, pp.7878~7881 (2001)
  23. "Claudin-10 expression level is associated with recurrence of primary hepatocelluar carcinoma", 11, pp.551~556 (2005)
  24. "Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes", 22, pp.3531~3539 (2004)
  25. "Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours", 46, pp.551~560 (2005)
  26. "The claudin gene family: expression in normal and neoplastic tissues", 6, pp.186~ (2006)

이 간행물의 다른 논문 (12건)

샘창자 위화생과 나이, 샘창자궤양, 헬리코박터의 관계송대현, 김현진, 이정희, 윤희상, 이종실, 고경혁, 김동출pp. 217-223Vater 팽대부 암종에서 Wntz/ β-catenin 신호 경로의 유전자 변화 및 메틸화 연구김영식, 김광일, 김한겸, 김정분, 채양석, 박상범, 염범우pp. 224-231유방 병변의 악성 진행에 따른 Survivin 단백 발현정지한, 이은정, 유진영, 강석진, 강창석, 이교영, 정찬권, 최현주pp. 238-243간암 세포주 및 위암 세포주에서 Nonsteroidal Anti-inflammatory Drug Activated Gene (NAG-1)의 기능 연구장태정pp. 244-251암색전의 맥관 내 맥관 형성에 관한 면역조직화학적 연구김조헌, 최찬, 이지신, 김성순, 한창우, 이재혁, 정상우pp. 252-257
원문 보기