Cervical Cytologic Smears in Pap Solution vs ThinPrep: Smear Characteristics and Diagnostic Agreement
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: The Pap smear has brought about a dramatic improvement in the prevention of cervical cancer in women worldwide. In an effort to decrease the occasional false negatives in the Pap smear and further increase the screened population, ThinPrep Pap Test (TP), a fluid-based cytology collection method, has been developed. With preservation of claimed advantages of TP, we have developed a Pap test solution for manual preparatory process and compared our manually processed fluid-based Pap smear with TP to identify cytologic similarities and differences between the two methods. Methods: Cervical swipes of 204 patients were prospectively collected in the ‘Pap solution’ and also in PreservCyt solution for TP. Diagnoses and smear characteristics were compared. Results: The diagnoses of the paired smears agreed in 190 of the 204 cases (93.1%). The smear characteristics regarding overall cellularity and background cellularities were similar in the two methods and the stainability of the cells was virtually the same. Conclusions: The ‘Pap solution’ has similar performance characteristics as TP in many aspects. With its advantages of cost-effectiveness and easier preparatory process, the ‘Pap solution’ can match previously implemented thin layer preparation.
Abstract
Background: The Pap smear has brought about a dramatic improvement in the prevention of cervical cancer in women worldwide. In an effort to decrease the occasional false negatives in the Pap smear and further increase the screened population, ThinPrep Pap Test (TP), a fluid-based cytology collection method, has been developed. With preservation of claimed advantages of TP, we have developed a Pap test solution for manual preparatory process and compared our manually processed fluid-based Pap smear with TP to identify cytologic similarities and differences between the two methods. Methods: Cervical swipes of 204 patients were prospectively collected in the ‘Pap solution’ and also in PreservCyt solution for TP. Diagnoses and smear characteristics were compared. Results: The diagnoses of the paired smears agreed in 190 of the 204 cases (93.1%). The smear characteristics regarding overall cellularity and background cellularities were similar in the two methods and the stainability of the cells was virtually the same. Conclusions: The ‘Pap solution’ has similar performance characteristics as TP in many aspects. With its advantages of cost-effectiveness and easier preparatory process, the ‘Pap solution’ can match previously implemented thin layer preparation.
참고문헌 (14)
- Austin RM, "College of American Pathologists Conference XXX on Quality and Liability Issues with the Papanicolaou smear: introduction", Arch Pathol Lab Med, 121, pp.227~228 (1997)
- Sawaya GF, "New technologies in cervical cytology screening: a word of caution", Obstet Gynecol, 94, pp.307~310 (1999)
- Gay JD, "False-negative results in cervical cytologic studies", Acta Cytol, 29, pp.1043~1046 (1985)
- DeMay RM, "Common problems in Papanicolaou smear interpretation", Arch Pathol Lab Med, 121, pp.229~238 (1997)
- Lee KR, "Comparison of conventional Papanicolaou smears and a fluid-based, thin-layer system for cervical cancer screening", Obstet Gynecol, 90, pp.278~284 (1997)
- Roberts JM, "Evaluation of the ThinPrep Pap test as an adjunct to the conventional Pap smear", Med J Aust, 167, pp.466~469 (1997)
- Papillo JL, "Evaluation of the ThinPrep Pap test in clinical practice: a seven-month, 16,314-case experience in northern Vermont", Acta Cytol, 42, pp.203~208 (1998)
- Hutchinson ML, "The efficacy of an automated preparation device for cervical cytology", Am J Clin Pathol, 96, pp.300~305 (1991)
- Wilbur DC, "Use of thin-layer preparations for gynecologic smears with emphasis on the cytomorphology of high-grade intraepithelial lesions and carcinomas", Diagn Cytopathol, 14, pp.201~211 (1996)
- Austin RM, "Increased detection of epithelial cell abnormalities by liquid-based gynecologic cytology preparations: a review of accumulated data", Acta Cytol, 42, pp.178~184 (1998)
- Dupree WB, "The promise and risk of a new technology: The Lehigh Valley Hospital’s experience with liquid-based cervical cytology", Cancer, 84, pp.202~207 (1998)
- Linder J, "ThinPrep Papanicolaou testing to reduce false-negative cervical cytology", Arch Pathol Lab Med, 122, pp.139~144 (1998)
- Awen C, "Efficacy of ThinPrep preparation of cervical smears: a 1,000-case, investigator-sponsored study", Diagn Cytopathol, 11, pp.33~36 (1994)
- Wilbur DC, "Interpretation of cervical cytology utilizing thin-layer processing: comparison of results with conventional smears", Mod Pathol, 5, pp.30A~ (1992)