Prognostic Significance of Aquaporin 5 Expression in Non-small Cell Lung Cancer
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Aquaporins are water channel proteins that play a major role in the movement of water in various human tissues. Recently, it has been found that aquaporins have influence in the carcinogenesis of human malignancies. We analyzed the prognostic impact of aquaporin 5 (AQP5) in non-small lung cancer (NSCLC). Methods: Seventy-six cases of NSCLC were studied, including 44 cases of adenocarcinoma (ADC) and 32 cases of squamous cell carcinoma (SQCC). Tissue microarray was constructed and immunohistochemical staining for AQP5 was performed. Results: AQP5 was positive in 59.2% of the total enrolled NSCLCs (63.7% in ADC and 53.1% in SQCC). The difference in expression of AQP5 according to the histologic grade of the tumor was significant (p < .047), but not in a serial order. When ADC and SQCC were separately evaluated, no significant difference was observed according to the histologic grade of the tumor (p = .076 in ADC and p = .631 in SQCC). No difference was observed between AQP5 expression and other demographic data and tumor characteristics. Disease-free survival (DFS) was higher in AQP5 negative cases than positive cases in ADC (p = .047), but no significance was found in SQCC (p = .068). We were unable to find a significance between AQP5 overexpression and overall survival in either ADC (p = .210) or SQCC (p = .533). Conclusions: AQP5 expression is associated with DFS in ADC of the lung and tumor grade of NSCLC. The present study suggests that AQP5 can be a prognostic factor of NSCLC.
Abstract
Background: Aquaporins are water channel proteins that play a major role in the movement of water in various human tissues. Recently, it has been found that aquaporins have influence in the carcinogenesis of human malignancies. We analyzed the prognostic impact of aquaporin 5 (AQP5) in non-small lung cancer (NSCLC). Methods: Seventy-six cases of NSCLC were studied, including 44 cases of adenocarcinoma (ADC) and 32 cases of squamous cell carcinoma (SQCC). Tissue microarray was constructed and immunohistochemical staining for AQP5 was performed. Results: AQP5 was positive in 59.2% of the total enrolled NSCLCs (63.7% in ADC and 53.1% in SQCC). The difference in expression of AQP5 according to the histologic grade of the tumor was significant (p < .047), but not in a serial order. When ADC and SQCC were separately evaluated, no significant difference was observed according to the histologic grade of the tumor (p = .076 in ADC and p = .631 in SQCC). No difference was observed between AQP5 expression and other demographic data and tumor characteristics. Disease-free survival (DFS) was higher in AQP5 negative cases than positive cases in ADC (p = .047), but no significance was found in SQCC (p = .068). We were unable to find a significance between AQP5 overexpression and overall survival in either ADC (p = .210) or SQCC (p = .533). Conclusions: AQP5 expression is associated with DFS in ADC of the lung and tumor grade of NSCLC. The present study suggests that AQP5 can be a prognostic factor of NSCLC.
참고문헌 (17)
- Travis WD, "WHO classification of tumours of the lung, pleura, thymus and heart", pp.26~52 (2015), IARC Press
- King LS, "Pathophysiology of the aquaporin water channels", Annu Rev Physiol, 58, pp.619~648 (1996)
- Verkman AS, "Water transport across mammalian cell membranes", Am J Physiol, 1(1 Pt 1), pp.C12~C30 (1996)
- Vogelstein B, "Cancer genes and the pathways they control", Nat Med, 10, pp.789~799 (2004)
- Saadoun S, "Increased aquaporin 1 water channel expression in human brain tumours", Br J Cancer, 87, pp.621~623 (2002)
- Moon C, "Involvement of aquaporins in colorectal carcinogenesis", Oncogene, 22, pp.6699~6703 (2003)
- Burghardt B, "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas", Gut, 52, pp.1008~1016 (2003)
- Woo J, "Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation", Cancer Lett, 264, pp.54~62 (2008)
- Vacca A, "Microvessel overexpression of aquaporin 1 parallels bone marrow angiogenesis in patients with active multiple myeloma", Br J Haematol, 113, pp.415~421 (2001)
- Moon C, "The mouse aquaporin-1gene", Genomics, 30, pp.354~357 (1995)
- Saadoun S, "Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption", Nature, 434, pp.786~792 (2005)
- Moon C, "Aquaporin expression in human lymphocytes and dendritic cells", Am J Hematol, 75, pp.128~133 (2004)
- Chae YK, "Expression of aquaporin 5 (AQP5)promotes tumor invasion in human non small cell lung cancer", PLoS One, 3, pp.E2162~ (2008)
- Guo K, "NFAT5 promotes proliferation and migration of lung adenocarcinoma cells in part through regulating AQP5 expression", Biochem Biophys Res Commun, 465, pp.644~649 (2015)
- Ishibashi H, "Sex steroid hormone receptors in human thymoma", J Clin Endocrinol Metab, 88, pp.2309~2317 (2003)
- Kang BW, "Expression of aquaporin-1, aquaporin-3, and aquaporin-5 correlates with nodal metastasis in colon cancer", Oncology, 88, pp.369~376 (2015)
- Lee SJ, "AQP5 expression predicts survival in patients with early breast cancer", Ann Surg Oncol, 21, pp.375~383 (2014)