Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer
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Background: Ezrin, a member of the ezrin-radixin-moesin family, is implicated in tumor progression, metastatic dissemination, and adverse outcomes, in several cancer types. In this study, we explored the clinicopathological significance of ezrin expression in non-small cell lung carcinomas (NSCLCs). Methods: Immunohistochemical analysis of tissue microarray with 112 surgically resected NSCLC specimens, was performed to examine the ezrin expression. We also correlated ezrin expression with other clinicopathological features and prognosis. Results: The ezrin-positive group revealed significantly higher correlation with pleural invasion (p=0.016) and pathologic stage (p=0.050). Univariate survival analysis showed that ezrin-positive group had a significantly shorter cancer-specific survival than ezrin-negative group (p=0.016). Meanwhile, female (p=0.030), no pleural invasion (p=0.023), no lymphatic invasion (p=0.026), and early pathologic stage (p= 0.008) significantly correlated with longer survival. Multivariate survival analysis showed that variables such as ezrin positivity (p=0.032), female (p=0.035), and early pathologic stage (p=0.001) were independent prognostic factors for NSCLC. Conclusions: Ezrin might be a molecular marker to predict poor prognosis of NSCLC.
Abstract
Background: Ezrin, a member of the ezrin-radixin-moesin family, is implicated in tumor progression, metastatic dissemination, and adverse outcomes, in several cancer types. In this study, we explored the clinicopathological significance of ezrin expression in non-small cell lung carcinomas (NSCLCs). Methods: Immunohistochemical analysis of tissue microarray with 112 surgically resected NSCLC specimens, was performed to examine the ezrin expression. We also correlated ezrin expression with other clinicopathological features and prognosis. Results: The ezrin-positive group revealed significantly higher correlation with pleural invasion (p=0.016) and pathologic stage (p=0.050). Univariate survival analysis showed that ezrin-positive group had a significantly shorter cancer-specific survival than ezrin-negative group (p=0.016). Meanwhile, female (p=0.030), no pleural invasion (p=0.023), no lymphatic invasion (p=0.026), and early pathologic stage (p= 0.008) significantly correlated with longer survival. Multivariate survival analysis showed that variables such as ezrin positivity (p=0.032), female (p=0.035), and early pathologic stage (p=0.001) were independent prognostic factors for NSCLC. Conclusions: Ezrin might be a molecular marker to predict poor prognosis of NSCLC.
참고문헌 (30)
- Jemal A, "Cancer statistics, 2007", CA Cancer J Clin, 57, pp.43~66 (2007)
- Tsuchiya T, "Stage IA non-small cell lung cancer: vessel invasion is a poor prognostic factor and a new target of adjuvant chemotherapy", Lung Cancer, 56, pp.341~348 (2007)
- Bretscher A, "ERM proteins and merlin: integrators at the cell cortex", Nat Rev Mol Cell Biol, 3, pp.586~599 (2002)
- Hunter KW, "Ezrin, a key component in tumor metastasis", Trends Mol Med, 10, pp.201~204 (2004)
- Brambilla D, "The Janus-faced role of Ezrin in “linking” cells to either normal or metastatic phenotype", Int J Cancer, 125, pp.2239~2245 (2009)
- Bruce B, "Expression of the cytoskeleton linker protein ezrin in human cancers", Clin Exp Metastasis, 24, pp.69~78 (2007)
- Zhao J, "Up-regulated expression of ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas", Histol Histopathol, 26, pp.1111~1120 (2011)
- Elzagheid A, "Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer", Hum Pathol, 39, pp.1737~1743 (2008)
- Korkeila EA, "Preoperative radiotherapy modulates ezrin expression and its value as a predictive marker in patients with rectal cancer", Hum Pathol, 42, pp.384~392 (2011)
- Wang L, "Expression of ezrin correlates with poor prognosis of nasopharyngeal carcinoma", Tumour Biol, 32, pp.707~712 (2011)
- Xie JJ, "Prognostic implication of ezrin expression in esophageal squamous cell carcinoma", J Surg Oncol, 104, pp.538~543 (2011)
- Elliott BE, "The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells", Breast Cancer Res, 7, pp.365~373 (2005)
- Khanna C, "The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis", Nat Med, 10, pp.182~186 (2004)
- 김찬, "Clinical Value of Ezrin Expression in Primary Osteosarcoma", Cancer Research and Treatment, 41(3), pp.138~144 (2009), 대한암학회
- 이재석, "Prognostic Significance of Ezrin Expression in Liposarcoma", The Korean Journal of Pathology, 42(5), pp.270~276 (2008), 대한병리학회
- Carneiro A, "Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas", J Clin Pathol, 64, pp.689~694 (2011)
- Abdou AG, "Immunohistochemical expression of ezrin in cutaneous basal and squamous cell carcinomas", Ann Diagn Pathol, 15, pp.394~401 (2011)
- Federici C, "Pleiotropic function of ezrin in human metastatic melanomas", Int J Cancer, 124, pp.2804~2812 (2009)
- Tokunou M, "Altered expression of the ERM proteins in lung adenocarcinoma", Lab Invest, 80, pp.1643~1650 (2000)
- Deng X, "Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases", Clin Exp Metastasis, 24, pp.107~119 (2007)
- Wang J, "Expression and correlation of ezrin and survivin in non-small cell lung cancer", Chinese-German J Clin Oncol, 9, pp.381~384 (2010)
- Travis WD, "World Health Organization classification of tumours: pathology and genetics of tumours of the lung, pleura, thymus and heart", pp.10~ (2004), IARC Press
- Travis WD, "Reporting lung cancer pathology specimens. Impact of the anticipated 7th edition TNM classification based on recommendations of the IASLC Staging Committee", Histopathology, 54, pp.3~11
- Patara M, "Ezrin expression as a prognostic marker in colorectal adenocarcinoma", Pathol Oncol Res, 17, pp.827~833 (2011)
- 오미혜, "Clinicopathological Significance of S100A4 Expression in Non-small Cell Lung Carcinomas", The Korean Journal of Pathology, 44(5), pp.477~482 (2010), 대한병리학회
- Bretscher A, "Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor", J Cell Biol, 108, pp.921~930 (1989)
- Hiscox S, "Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin", beta-catenin, 1999, pp.112(Pt 18), 3081~3090
- McClatchey AI, "Merlin and ERM proteins: unappreciated roles in cancer development?", Nat Rev Cancer, 3, pp.877~883 (2003)
- Fiévet B, "ERM proteins in epithelial cell organization and functions", Biochim Biophys Acta, 1773, pp.653~660 (2007)
- Wan X, "Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma", Cancer Res, 65, pp.2406~2411 (2005)