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Unusual Excessive Callus Formation in the Intertrochanteric Fracture Treated with Teriparatide

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초록

This is the first case report on the effects of teriparatide on the course of healing of an intertrochanteric hip fracture with unusually excessive callus formation even after discontinuation of treatment in an elderly woman. This case highlights the long-term effects of parathyroid hormone, even after administration of short-term, intermittent dosages for healing of osteoporotic fracture.

Abstract

This is the first case report on the effects of teriparatide on the course of healing of an intertrochanteric hip fracture with unusually excessive callus formation even after discontinuation of treatment in an elderly woman. This case highlights the long-term effects of parathyroid hormone, even after administration of short-term, intermittent dosages for healing of osteoporotic fracture.

참고문헌 (7)

  1. Dempster DW, "Anabolic actions of parathyroid hormone on bone", Endocr Rev, 14, pp.690~709 (1993)
  2. Hodsman AB, "Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use", Endocr Rev, 26, pp.688~703 (2005)
  3. Andreassen TT, "Intermittent parathyroid hormone(1-34)treatment increases callus formation and mechanical strength of healing rat fractures", J Bone Miner Res, 14, pp.960~968 (1999)
  4. Skripitz R, "Parathyroid hormone (1-34) increases the density of rat cancellous bone in a bone chamber. A dose-response study", J Bone Joint Surg Br, 82, pp.138~141 (2000)
  5. Vahle JL, "Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety", Toxicol Pathol, 30, pp.312~321 (2002)
  6. Aspenberg P, "Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures", J Bone Miner Res, 25, pp.404~414 (2010)
  7. Peichl P, "Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women", J Bone Joint Surg Am, 93, pp.1583~1587 (2011)

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