Current Role and Application of Teriparatide in Fracture Healing of Osteoporotic Patients: A Systematic Review
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Background: The use of osteoanabolic agents to facilitate fracture healing has been of heightened interest to the field of orthopaedic trauma. This study aimed to evaluate the evidence of teriparatide for fracture healing and functional recovery in osteoporotic patients. Methods: We performed a literature search in PubMed, EMBASE, Web of Science, and the Cochrane Library using terms including “Fracture” [tiab] AND “Teriparatide [tiab] OR “PTH” [tiab]. Results: This systematic review included 6 randomized clinical trials, 4 well-controlled retrospective studies, and 1 retrospective post hoc subgroup analysis. Fracture location was 2 in pelvis, 3 in proximal femur, 1 in distal femur, 1 in shoulder, 2 in wrist and 2 in spine. The use of teriparatide yielded positive effects on radiographic bone healing in 6 studies, but was not associated with better radiographic outcome in 3. In terms of functional recovery, teriparatide injection was related with decrease in pain or shorter time to mobilization in 6 studies, but not related with pain numerical scale and mobility in 3. Conclusions: Our findings suggest that teriparatide provide selective advantages to fracture healing or functional recovery in the management of osteoporotic fractures. A better understanding of the role of teriparatide on osteoporotic fractures requires greater evidences from large volume prospective trials.
Abstract
Background: The use of osteoanabolic agents to facilitate fracture healing has been of heightened interest to the field of orthopaedic trauma. This study aimed to evaluate the evidence of teriparatide for fracture healing and functional recovery in osteoporotic patients. Methods: We performed a literature search in PubMed, EMBASE, Web of Science, and the Cochrane Library using terms including “Fracture” [tiab] AND “Teriparatide [tiab] OR “PTH” [tiab]. Results: This systematic review included 6 randomized clinical trials, 4 well-controlled retrospective studies, and 1 retrospective post hoc subgroup analysis. Fracture location was 2 in pelvis, 3 in proximal femur, 1 in distal femur, 1 in shoulder, 2 in wrist and 2 in spine. The use of teriparatide yielded positive effects on radiographic bone healing in 6 studies, but was not associated with better radiographic outcome in 3. In terms of functional recovery, teriparatide injection was related with decrease in pain or shorter time to mobilization in 6 studies, but not related with pain numerical scale and mobility in 3. Conclusions: Our findings suggest that teriparatide provide selective advantages to fracture healing or functional recovery in the management of osteoporotic fractures. A better understanding of the role of teriparatide on osteoporotic fractures requires greater evidences from large volume prospective trials.
참고문헌 (48)
- Murray TM, "Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl- terminal ligands", Endocr Rev, 26, pp.78~113 (2005)
- Kurland ES, "Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers", J Clin Endocrinol Metab, 85, pp.3069~3076 (2000)
- McClung MR, "Romosozumab in postmenopausal women with low bone mineral density", N Engl J Med, 370, pp.412~420 (2014)
- Kaufman JM, "Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapy", Osteoporos Int, 16, pp.510~516 (2005)
- Lindsay R, "Sustained vertebral fracture risk reduction after withdrawal of teriparatide in postmenopausal women with osteoporosis", Arch Intern Med, 164, pp.2024~2030 (2004)
- Neer RM, "Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis", N Engl J Med, 344, pp.1434~1441 (2001)
- therapy on bone density in men with osteoporosis, "J Bone Miner Res", 2003, 9~17
- Peichl P, "Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women", J Bone Joint Surg Am, 93, pp.1583~1587 (2011)
- Prevrhal S, "Teriparatide vertebral fracture risk reduction determined by quantitative and qualitative radiographic assessment", Curr Med Res Opin, 25, pp.921~928 (2009)
- Prince R, "Sustained nonvertebral fragility fracture risk reduction after discontinuation of teriparatide treatment", J Bone Miner Res, 20, pp.1507~1513 (2005)
- Binder EF, "Effects of extended outpatient rehabilitation after hip fracture: a randomized controlled trial", JAMA, 292, pp.837~846 (2004)
- Magaziner J, "Recovery from hip fracture in eight areas of function", J Gerontol A Biol Sci Med Sci, 55, pp.M498~M507 (2000)
- Kawaguchi H, "A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo-controlled trial", J Bone Miner Res, 25, pp.2735~2743 (2010)
- Sharrard WJ, "A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures", J Bone Joint Surg Br, 72, pp.347~355 (1990)
- Wright JG, "Grades of recommendation", J Bone Joint Surg Am, 87, pp.1909~1910 (2005)
- Komrakova M, "Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats", Bone, 47, pp.480~492 (2010)
- Lina IA, "Quantitative study of parathyroid hormone (1-34) and bone morphogenetic protein-2 on spinal fusion outcomes in a rabbit model of lumbar dorsolateral intertransverse process arthrodesis", Spine, 39, pp.347~355 (2014)
- Morimoto T, "Effect of intermittent administration of teriparatide (parathyroid hormone 1-34) on bone morphogenetic protein-induced bone formation in a rat model of spinal fusion", J Bone Joint Surg Am, 96, pp.e107~ (2014)
- Mancilla EE, "Teriparatide as a systemic treatment for lower extremity nonunion fractures: a case series", Endocr Pract, 21, pp.136~142 (2015)
- Chiang CY, "Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy", Bone, 52, pp.360~365 (2013)
- Miyakoshi N, "Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide", J Bone Miner Metab, 33, pp.553~559 (2015)
- Guidelines for preclinical evaluation and clinical trials in osteoporosis, "World Health Organization", World Health Organization, ~ (1998)
- Brown JP, "2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada", CMAJ, 167, pp.S1~S34 (2002)
- Cerocchi I, "Fragility fractures: the clinical pathway", Aging Clin Exp Res, 25(Suppl 1), pp.S43~S45 (2013)
- Ralston SH, "Diagnosis and management of osteoporosis", Practitioner, 259, pp.15~19 (2015)
- 우제현, "Osteoporotic Fracture: 2015 Position Statement of the Korean Society for Bone and Mineral Research", 대한골대사학회지, 22(4), pp.175~181 (2015), 대한골대사학회
- "Osteoporosis: assessing the risk of fragility fracture" (2012)[URL]
- Aspenberg P, "Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures", J Bone Miner Res, 25, pp.404~414 (2010)
- 하용찬, "Trend in Hip Fracture Incidence and Mortality in Korea: A Prospective Cohort Study from 2002 to 2011", Journal of Korean Medical Science, 30(4), pp.483~488 (2015), 대한의학회
- Aspenberg P, "Effects of teriparatide compared with risedronate on recovery after pertrochanteric hip fracture: results of a randomized, active-controlled, double-blind clinical trial at 26 weeks", J Bone Joint Surg Am, 98, pp.1868~1878 (2016)
- Bhandari M, "Does teriparatide improve femoral neck fracture healing: results from a randomized placebo-controlled trial", Clin Orthop Relat Res, 474, pp.1234~1244 (2016)
- 송형근, "고령 환자 골절에서 가골 생성 촉진을 위한 부갑상선 호르몬의 간헐적 투여", 대한골절학회지, 25(4), pp.295~299 (2012), 대한골절학회
- Huang TW, "Teriparatide improves fracture healing and early functional recovery in treatment of osteoporotic intertrochanteric fractures", Medicine, 95, pp.e3626~ (2016)
- Johansson T, "PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures. A randomized, controlled study of 40 patients", Acta Orthop, 87, pp.79~82 (2016)
- Hadji P, "The effect of teriparatide compared with risedronate on reduction of back pain in postmenopausal women with osteoporotic vertebral fractures", Osteoporos Int, 23, pp.2141~2150 (2012)
- Tsuchie H, "The effect of teriparatide to alleviate pain and to prevent vertebral collapse after fresh osteoporotic vertebral fracture", J Bone Miner Metab, 34, pp.86~91 (2016)
- Aspenberg P, "Teriparatide improves early callus formation in distal radial fractures", Acta Orthop, 81, pp.234~236 (2010)
- Orive M, "Changes in health-related quality of life and activities of daily living after hip fracture because of a fall in elderly patients: a prospective cohort study", Int J Clin Pract, 69, pp.491~500 (2015)
- Vergara I, "Factors related to functional prognosis in elderly patients after accidental hip fractures: a prospective cohort study", BMC Geriatr, 14, pp.124~ (2014)
- 서중배, "Influence of Early Bisphosphonate Administration for Fracture Healing in Patients with Osteoporotic Proximal Humerus Fractures", Clinics in Orthopedic Surgery, 8(4), pp.437~443 (2016), 대한정형외과학회
- Alkhiary YM, "Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34)", J Bone Joint Surg Am, 87, pp.731~741 (2005)
- Andreassen TT, "Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures", J Bone Miner Res, 14, pp.960~968 (1999)
- Barnes GL, "Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment", J Bone Joint Surg Am, 90(Suppl 1), pp.120~127 (2008)
- Bashutski JD, "Teriparatide and osseous regeneration in the oral cavity", N Engl J Med, 363, pp.2396~2405 (2010)
- Andreassen TT, "Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone", Acta Orthop Scand, 72, pp.304~307 (2001)
- Lou S, "The effect of teriparatide on fracture healing of osteoporotic patients: a meta-analysis of randomized controlled trials", Biomed Res Int, 2016, pp.6040379~ (2016)
- Shi Z, "Effectiveness of teriparatide on fracture healing: a systematic review and meta-analysis", PLoS One, 11, pp.e0168691~ (2016)
- Huang TW, "Effect of teriparatide on unstable pertrochanteric fractures", Biomed Res Int, 2015, pp.568390~ (2015)