표면 윤활 물질에 의한 인공 고관절 코발트-크롬 대퇴골두의 마찰 및 윤활 반응
The Tribological and Lubrication Responses of a Cobalt-Chromium Femoral Head in Total Hip Arthroplasty
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목적: 인공 고관절에서 알부민의 경계윤활제로서의 영향을 나노 단위 수준에서 확인하기 위하여,코발트-크롬 대퇴골두를 AFM (Atomic Force Microscope) 을 사용하여 마찰 관련 지표의 변화를 분석하였다. 대상 및 방법: 환자의 코발트-크롬 대퇴골 삽입물의 마모된 부위로부터 실험 모델을 제작하였다. 사용된 윤활제는 대조용액으로 PBS (Phosphate Buffered Saline)가 사용되었으며 실험용액으로는 우혈청 알부민(BSA: Bovine Serum Albumin)가 사용되었다. 결과: 마찰계수 (μ)는 실험군과 대조군 사이의 마찰계수가 통계적으로 유의하였다(10 mg/ml, 20mg/ml, 30 mg/ml, 40 mg/ml BSA: p<0.001). 각 농도의 BSA 혼합 용액 사이에서도 통계적으로 유의한 마찰계수의 차이를 보였으며, 30 mg/ml와 40 mg/ml사이에서는 마찰계수의 차이가유의하지 않았다. 결론: 코발트-크롬 대퇴골두의 표면에 흡착되어서 경계 윤활 작용의 효과를 극대화 시킬 수 있는효과적인 단백질 농도가 존재한다.
Abstract
Purpose: This study aimed at investigating the role of albumin as a boundary lubricant in the lubrication of the Co-Cr femoral head of artificial hip implants by measuring the tribological parameters of the Co-Cr femoral head with Atomic Force Microscope (AFM) techniques. Materials and Methods: Samples were prepared from the main wear region of a Co-Cr femoral head from revision hip surgery. Two types of solutions were prepared as lubricants: PBS (Phosphate Buffered Saline) as a control solution and BSA (Bovine Serum Albumin) as a lubricant at concentrations of 10, 20, 30 and 40 mg/ml in PBS solution. Results: There were statistically significant differences in the frictional coefficients (μ) of a Co-Cr head between the PBS control and all the concentrations of BSA (10, 20, 30, 40 mg/ml) (P<0.001). Similarly, there were statistically significant differences for the μ between the BSA concentrations of 10, 20, 30 and 40 mg/m for all the cases except between the BSA of 30 and 40 mg/ml (P<0.01). Conclusion: There exists a maximum protein concentration of BSA to play a role as an effective boundary lubricant through adsorption on the surface of Co-Cr femoral head.
참고문헌 (24)
- Brockett C, "Friction of total hip replacements with different bearings and loading conditions", J Biomed Mater Res B Appl Biomater, 81, pp.508~515 (2007)
- Sedel L, "Evolution of alumina-on-alumina implants: a review", Clin Orthop Relat Res, 379, pp.48~54 (2000)
- Bhushan B, "Nanotribology, nanomechanics and nanomaterials characterization", Philos Transact A Math Phys Eng Sci, 366, pp.1351~1381 (2008)
- Park S, "Microscale frictional response of bovine articular cartilage from atomic force microscopy", J Biomech, 37, pp.1679~1687 (2004)
- Gispert MP, "Friction and wear mechanisms in hip prosthesis: Comparison of joint materials behaviour in several lubricants", Wear, 260, pp.149~158 (2006)
- Scholes SC, "The effects of material combination and lubricant on the friction of total hip prostheses", Wear, 241, pp.209~213 (2000)
- Cho HJ, "Wear behavior of UHMWPE sliding on artificial hip arthroplasty materials", Mater Chem Phys, 88, pp.9~16 (2004)
- Saikko V, "Friction measurement in the biaxial rocking motion hip joint simulator", J. Tribol, 131 (2009)
- Wang FC, "Lubrication and friction prediction in metal-on-metal hip implants", Phys Med Biol, 53, pp.1277~1293 (2008)
- Duong CT, "Tribological property of the cobalt-chromium femoral head with different regions of wear in total hip arthroplasty", Proc Inst Mech Eng H, 224, pp.541~549 (2010)
- Arias DF, "Determination of friction coefficient on ZrN and TiN using lateral force microscopy", Wear, 261, pp.1232~1236 (2006)
- Smith AM, "Role of friction and tangential force variation in the subjective scaling of tactile roughness", Exp Brain Res, 144, pp.211~223 (2002)
- Jiang H, "Influence of surface roughness and contact load on friction coefficient and scratch behavior of thermoplastic olefins", Applied Surface Science, 254, pp.4494~4499 (2008)
- Menezes PL, "Influence of roughness parameters on coefficient of friction under lubricated conditions", Sadhana, 33, pp.181~190 (2008)
- Menezes PL, "On the effect of surface texture on friction and transfer layer formation-A study using Al and steel pair", Wear, 265, pp.1655~1669 (2008)
- Sedlacek M, "Influence of surface preparation on roughness parameters, friction and wear", Wear, 266, pp.482~487 (2009)
- Hwang DS, "Alumina femoral head fracture in uncemented total hip arthroplasty with a ceramic sandwich cup", J Arthroplasty, 22, pp.468~471 (2007)
- Teoh SH, "An elasto-plastic finite element model for polyethylene wear in total hip arthroplasty", J Biomech, 35, pp.323~330 (2002)
- Brown SS, "A review of lubricant conditions for wear simulation in artificial hip joint replacements", Tribol Trans, 49, pp.72~78 (2006)
- Saikko V, "Effect of lubricant protein concentration on the wear of ultra-high molecular weight polyethylene sliding against a CoCr counterface", J. Tribol, 125, pp.638~642 (2003)
- Clarke IC, "Multi-laboratory simulator studies on effects of serum proteins on PTFE cup wear", Wear, 250, pp.188~198 (2001)
- Wang A, "The effects of lubricant composition on in vitro wear testing of polymeric acetabular components", J Biomed Mater Res B Appl Biomater, 68, pp.45~52 (2004)
- O’Connor DT, "New insight into the mechanism of hip prosthesis loosening: effect of titanium debris size on osteoblast function", J Orthop Res, 22, pp.229~236 (2004)
- Heubergera MP, "Protein-mediated boundary lubrication in arthroplasty", Biomaterials, 26, pp.1165~1173 (2005)