본문 바로가기
KERD
논문KCI 등재

Panton-Valentine Leukocidin 양성 지역사회관련 메티실린 내성 황색포도알균에 의한 항문주위 농양 1예: 국내 보고 및 동아시아 증례 문헌고찰

A Case of Perianal Abscess due toPanton-Valentine Leukocidin PositiveCommunity-Associated Methicillin-ResistantStaphylococcus aureus : Report in Koreaand Literature Review from the Far East

0

조회

0

다운로드

6

인용

0

참고문헌

주제분류내과학

초록

최근 Panton-Valentine leukocidin (PVL) 유전자 양성인 지역사회관련 메티실린내성 포도알균이 전세계적으로 보고되고 있지만 국내에서는 아직 드물다. 저자들은 76세 여자환자에서 PVL양성 지역사회관련 메티실린 내성 포도알균에 의한 광범위한 항문주위 농양을 진단하고 성공적으로 치료하였다. 분자역학연구를 통해 본 균주는 미국에서 유행하는 USA300주와 매우 유사하고, staphylococcal cassette chromosome mec mec (SCCmec) type IV, multilocus sequence typing ST8, spa type type 1, accessory gene regulator locus (agr) group I이 관련되어있었다. 문헌조사 결과 동아시아에서 보고된 PVL 양성 지역사회관련 메티실린 내성 포도알균은 분자역학적 특성이 다양하고, 미국 및 유럽 증례와 비교해 PVL 유전자가 비교적 드물었다.

Abstract

Community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) with Panton- Valentine leukocidin (PVL) genes have recently emerged worldwide, but infections due to PVL carrying CA-MRSA strains have never been reported in Korea. We report a case of extensive perianal abscess due to PVL+ CA-MRSA in a 76-year-old Korean female patient, of which genetic background was very close to USA300. It belonged to staphylococcal cassette chromosome mec element (SCCmec) type IV, ST8 of multilocus sequence typing (MLST), type 1 spa type, and accessory gene regulator locus (agr) group I. Comprehensive literature reviews from the Far East showed molecular characteristics were diverse and PVL genes were infrequently found than in western countries.

참고문헌 (26)

  1. Fridkin SK, "Active Bacterial Core Surveillance Program of the Emerging Infections Program Network: Methicillin resistant Staphylococcus aureus disease in three communities", N Engl J Med, 352, pp.1436~1444 (2005)
  2. Zetola N, "Community-acquired methicillin-resistant Staphylococcus aureus: an emerging threat", Lancet Infect Dis, 5, pp.275~286 (2005)
  3. Kim HB, "Nationwide surveillance for Staphylococcus aureus with reduced susceptibility to vancomycin in Korea", J Clin Microbiol, 41, pp.2279~2281 (2003)
  4. Vandenesch F, "Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence", Emerg Infect Dis, 9, pp.978~984 (2003)
  5. Wang R, "Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA", Nat Med, 13, pp.1510~1514 (2007)
  6. Bubeck Wardenburg J, "Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumoniae", Nat Med, 13, pp.1405~1406 (2007)
  7. Voyich JM, "Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin- resistant Staphylococcus aureus disease", J Infect Dis, 194, pp.1761~1770 (2006)
  8. Labandeira-Rey M, "Staphylococcus areus Panton-Valentine leukocidin causes necrotizing pneumoniae", Science, 315, pp.1130~1133 (2007)
  9. Kim JS, "Panton-Valentine leukocidin positive Staphylococcus aureus isolated from blood in Korea", Korean J Lab Med, 27, pp.286~291 (2007)
  10. Song JS, "Multicenter study for frequency and clinical features of community- associated methicillin-resistant Staphylococus aureus in Korea", Infect Chemother, 38, pp.325~333 (2006)
  11. Kwon NH, "Staphylococcal cassette chromosome mec (SCCmec) characterization and molecular analysis for methicillin-resistant Staphylococcus aureus and novel SCCmec subtype IVg isolated from bovine milk in Korea", J Antimicrob Chemother, 56, pp.624~632 (2005)
  12. Kim ES, "A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea", J Antimicrob Chemother, 60, pp.1108~1114 (2007)
  13. "Clinical and Laboratory Standards Institute:Performance standards for antimicrobial susceptibility testing. Sixteenth informational supplement. Approved standard M100-S16. Wayne, PA, CLSI", ~ (2006)
  14. Becker K, "Development and evaluation of a quality-controlled ribosomal sequence database for 16S ribosomal DNA-based identification of Staphylococcus species", J Clin Microbiol, 42, pp.4988~4995 (2004)
  15. Jarraud S, "Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease", Infect Immun, 70, pp.631~641 (2002)
  16. Park C, "Predominance of community-associated methicillin-resistant Staphylococcus aureus strains carrying staphylococcal chromosome cassette mec type IVA in Korea", J Clin Microbiol, 45, pp.4021~4026 (2007)
  17. Cha HY, "Prevalence of the ST239 clone of methicillin- resistant Staphylcoccus aureus and differences in antimicrobial susceptibilities of ST239 and ST5 clones identified in a Korean hospital", J Clin Microbiol, 43, pp.3610~3614 (2005)
  18. Ko KS, "Distribution of major genotypes among methicillin-resistant Staphylococcus aureus clones in Asian countries", J Clin Microbiol, 43, pp.421~426 (2005)
  19. Takizawa Y, "A Panton-Valentine leukocidin (PVL)-positive community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strain, another such strain carrying a multiple-drug resistance plasmid, and other more-typical PVL-negative MRSA strains found in Japan", J Clin Microbiol, 43, pp.3356~3363 (2005)
  20. Yamamoto T, "Molecular characteristics and in vitro susceptibility to antimicrobial agents, including the des-fluoro (6) quinolone DX-619, of Panton-Valentine leucocidin- positive methicillin-resistant Staphylococcus aureus isolates from the community and hospitals", Antimicrob Agents Chemother, 50, pp.4077~4086 (2006)
  21. Wang CC, "Epidemiological typing of community-acquired methicillin-resistant Staphylococcus aureus isolates from children in Taiwan", Clin Infect Dis, 39, pp.481~487 (2004)
  22. Bolye-Vavra S, "Successful multiresistant community-associated methicillin resistant Staphylococcus aureus lineage from Taipei, Taiwan, that carries either the novel staphylococcal chromosom cassette mec (SCCmec) type VT or SCCmec type IV", J Clin Microbiol, 43, pp.4719~4730 (2005)
  23. Lo WT, "Community acquired methicillin-resistant Staphylococcus aureus in children, Taiwan", Emerg Infect Dis, 12, pp.1267~1270 (2006)
  24. Huang H, "Comparison of community-associated methicillin-resistant Staphylococcus aureus (MRSA) and hospital-associated MRSA infections in Sacramento, California", J Clin Microbiol, 44, pp.2423~2427 (2006)
  25. Li GH, ":Emergence of methicilin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin gene in Shanghai, China", Int J Infect Dis, 10, pp.482~483 (2006)
  26. Narita S, "Phage conversion of Panton- Valentine leukocidin in Staphylococcus aureus: molecular analysis of a PVL-converting phage, phiSLT", Gene, 268, pp.195~206 (2001)

관련 논문AI추천

국내거주 외국인에 발생한 Panton-Valentine leukocidin (PVL) 양성 USA300 지역사회획득 메티실린 내성 황색포도알균 두경부 농양 1예고관수, 권기태, 김보연, 김상동, 배상수, 백인엽, 이신원, 정동형대한감염학회 · Infection and Chemotherapy2012 · 제44권 제6호국내 환자의 혈액에서 분리된 Panton-Valentine 독소 양성인Staphylococcus aureus김의종, 김재석, 김한성, 박정수, 송원근, 이규만, 조현찬대한진단검사의학회 · Annals of Laboratory Medicine2007 · 제27권 제4호Recurrent Familial Furunculosis Associated with Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus ST1박지영, Il Kwon Bae, Ji Hyun Park, Jin Young Lee, Seri Jeong, Sol Jin대한소아감염학회 · Pediatric Infection and Vaccine2018 · 제25권 제2호ST714-SCCmec type IV CA-MRSA isolated from a Child with Recurrent Skin and Soft Tissue Infections in South Korea: A Case Report김서희, 유리나, 이진아대한소아감염학회 · Pediatric Infection and Vaccine2016 · 제23권 제1호A Fatal Case of Infective Endocarditis Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus ST72 in Korea정진원, 최성호대한임상미생물학회 · Annals of Clinical Microbiology2008 · 제11권 제2호지역사회 관련 메티실린내성 황색포도알균에 의한 균혈증 2예강은정, 김정현, 김태형, 박수진, 신희봉, 전민혁, 정윤석, 추은주대한감염학회 · Infection and Chemotherapy2009 · 제41권 제1호

이 간행물의 다른 논문 (10건)