지역사회 관련 메티실린내성 황색포도알균에 의한 균혈증 2예
Two Cases of Bacteremia Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus
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Recent reports have described an increasing incidence of community-associated methicillin- resistant Staphylococcus aureus (CA-MRSA) in patients who do not exhibit established risk factors for healthcare exposure. We report two cases of CA-MRSA bacteremia complicated by vertebral osteomyelitis. Both of CA-MRSA isolates were resistant to beta-lactam agents, but susceptible to clindamycin, trimethoprim-sulfamethoxazole, gentamicin, ciprofloxacin, and tetracycline. Both isolates carried staphylococcal cassette chromosome mec (SCCmec) type IVA, and were identified as sequence type (ST) 72 by mlultilocus sequence typing (MLST). However, the Panton-Valentine leukocidin (PVL) gene was not identified.
Abstract
Recent reports have described an increasing incidence of community-associated methicillin- resistant Staphylococcus aureus (CA-MRSA) in patients who do not exhibit established risk factors for healthcare exposure. We report two cases of CA-MRSA bacteremia complicated by vertebral osteomyelitis. Both of CA-MRSA isolates were resistant to beta-lactam agents, but susceptible to clindamycin, trimethoprim-sulfamethoxazole, gentamicin, ciprofloxacin, and tetracycline. Both isolates carried staphylococcal cassette chromosome mec (SCCmec) type IVA, and were identified as sequence type (ST) 72 by mlultilocus sequence typing (MLST). However, the Panton-Valentine leukocidin (PVL) gene was not identified.
참고문헌 (12)
- Diederen BM, "The emergence of infections with community-associated methicillin resistant Staphylococcus aureus", J Infect, 52, pp.157~168 (2006)
- Salgado CD, "Community-acquired methicillin-resistant Staphylococcus aureus: a meta- analysis of prevalence and risk factors", Clin Infect Dis, 36, pp.131~139 (2003)
- Naimi TS, "Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection", JAMA, 290, pp.2976~2984 (2003)
- Oliveira DC, "Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus", Antimicrob Agents Chmother, 46, pp.2155~2161 (2002)
- King MD, "Emergence of community- acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections", ANN Intern Med, 144, pp.309~317 (2006)
- Gillet Y, "Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotizing pneumonia in young immunocompetent patients", Lancet, 359, pp.753~759 (2002)
- Vandenesch F, "Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton- Valentine leukocidin genes: worldwide emergence", Emerg Infect Dis, 9, pp.978~984 (2003)
- Zetola N, "Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat", Lancet Infect Dis, 5, pp.275~286 (2005)
- 송진수, "국내 다기관에서 조사한 지역사회획득 메티실린내성 황색포도알균의 빈도와 임상적 특성", Infection and Chemotherapy, 38(6), pp.325~333 (2006), 대한감염학회
- Kim ES, "A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea", J Antimicrob Chemother, 60, pp.1108~1114 (2007)
- Park C, "Predominance of community- associated methicillin-resistant Staphylococcus aureus strains carrying staphylococcal chromosome cassette mec type IVA in South Korea", J Clin Microbiol, 45, pp.4521~4526 (2007)
- Moran GJ, "Methicillin-resistant S. aureus infections among patients in the emergency department", N Engl J Med, 355, pp.666~674 (2006)
